Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment - Xia, Xuyang; He, Chenjia; Xue, Zhinan; Wang, Yuelan; Qin, Yun; Ren, Zhixiang; Huang, Yupeng; Luo, Han; Chen, Hai-Ning; Zhang, Wei-Han; Huang, Li-Bin; Shi, Yunying; et al. (Nature communications, 2025)
Keywords: 13/31; 13/51; 38/77; 45/47; 45/91; 631/208/514/1949; 631/250/1619/554/1898; 631/250/2502; 631/250/2504/342; 692/699/1670/498; 96/47; Adalimumab - pharmacology; Adalimumab - therapeutic use; Animal models; Animals; Arthritis; Arthritis, Experimental - drug therapy; Arthritis, Experimental - immunology; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - metabolism; Arthritis, Rheumatoid - pathology; CD4 antigen; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Cell culture; Cell interactions; CXCL13 protein; Disease Models, Animal; Female; Gene expression; Gene sequencing; Humanities and Social Sciences; Humans; Immune system; Inflammation; Janus Kinase Inhibitors - pharmacology; Janus Kinase Inhibitors - therapeutic use; Lymphocytes; Lymphocytes T; Macrophages; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Male; Mice; Middle Aged; Monoclonal antibodies; multidisciplinary; Piperidines; Pyrimidines - pharmacology; Pyrimidines - therapeutic use; Rheumatoid arthritis; Science; Science (multidisciplinary); Single-Cell Analysis - methods; Stat1 protein; Synovial fluid; Synovial Fluid - cytology; Synovial Fluid - drug effects; Synovial Fluid - immunology; Synoviocytes; Synoviocytes - drug effects; Synoviocytes - immunology; Synoviocytes - metabolism; Tumor Necrosis Factor Inhibitors - pharmacology; Tumor Necrosis Factor Inhibitors - therapeutic use; Tumor Necrosis Factor-alpha - antagonists & inhibitors