Neuroinflammation in Low-Level PM2.5-Exposed Rats Illustrated by PET via an Improved Automated Produced [18F]FEPPA: A Feasibility Study

• Published in: Molecular imaging Vol. 2022
• Main Authors: Cheng, Mei-Fang, Cheng, Tsun-Jen, Guo, Yue Leon, Chiu, Ching-Hung, Wu, Hung-Ming, Yen, Ruoh-Fang, Huang, Ya-Yao, Huang, Wen-Sheng, Shiue, Chyng-Yann
• Format: Journal Article
• Language: English
• Published: Thousand Oaks Hindawi 2022; Sage Publications Ltd; SAGE Publishing
• Subjects: Automation; Brain; Cyclotrons; Exposure; Feasibility studies; Fluorine isotopes; High-performance liquid chromatography; Imaging; Inflammation; Liquid chromatography; Neuroimaging; Particulate matter; Positron emission; Positron emission tomography; Purification; Radiochemistry; Stability criteria; Stability tests; Synthesis

Background. [18F]FEPPA is a potent TSPO imaging agent that has been found to be a potential tracer for imaging neuroinflammation. In order to fulfill the demand of this tracer for preclinical and clinical studies, we have developed a one-pot automated synthesis with simplified HPLC purification of t...