Monocytic microparticles activate endothelial cells in an IL-1β–dependent manner

• Published in: Blood Vol. 118; no. 8; pp. 2366 - 2374
• Main Authors: Wang, Jian-Guo, Williams, Julie C., Davis, Beckley K., Jacobson, Ken, Doerschuk, Claire M., Ting, Jenny P.-Y., Mackman, Nigel
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 25.08.2011; Americain Society of Hematology; American Society of Hematology
• Subjects: Biological and medical sciences; Carrier Proteins - antagonists & inhibitors; Carrier Proteins - genetics; Cell Adhesion Molecules - physiology; Cell Line; Cell-Derived Microparticles - drug effects; Cell-Derived Microparticles - physiology; Cells, Cultured; Endothelial Cells - physiology; Gene Knockdown Techniques; Hematologic and hematopoietic diseases; Humans; Inflammasomes - physiology; Inflammation Mediators - physiology; Interleukin 1 Receptor Antagonist Protein - pharmacology; Interleukin-1beta - physiology; Lipopolysaccharides - toxicity; Medical sciences; Monocytes - drug effects; Monocytes - physiology; NLR Family, Pyrin Domain-Containing 3 Protein; Phagocytes, Granulocytes, and Myelopoiesis; Receptors, Interleukin-1 - antagonists & inhibitors; Signal Transduction; Vascular Biology; Interleukin 1β; Microparticle; Endothelial cell; Hematology; Monocyte; Cytokine

Microparticles (MPs) are shed from activated and dying cells. They can transmit signals from cell to cell, locally or at a distance through the circulation. Monocytic MPs are elevated in different diseases, including bacterial infections. Here, we investigated how monocytic MPs activate endothelial...