T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma - Stromnes, Ingunn M.; Schmitt, Thomas M.; Hulbert, Ayaka; Brockenbrough, J. Scott; Nguyen, Hieu N.; Cuevas, Carlos; Dotson, Ashley M.; Tan, Xiaoxia; Hotes, Jennifer L.; Greenberg, Philip D.; Hingorani, Sunil R. (Cancer cell, 2015)
Keywords: Animals; Antigens - immunology; Carcinoma, Pancreatic Ductal - immunology; Carcinoma, Pancreatic Ductal - pathology; Carcinoma, Pancreatic Ductal - therapy; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins - genetics; GPI-Linked Proteins - immunology; GPI-Linked Proteins - metabolism; HEK293 Cells; Humans; Immunoblotting; Immunotherapy, Adoptive - methods; Jurkat Cells; Kaplan-Meier Estimate; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - therapy; Protein Engineering - methods; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - immunology; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - transplantation; Transfection; Tumor Cells, Cultured