Unveiling the mechanistic link between extracellular amyloid fibrils, mechano-signaling and YAP activation in cancer

• Published in: Cell death & disease Vol. 15; no. 1; p. 28
• Main Authors: Farris, Francesco, Elhagh, Alice, Vigorito, Ilaria, Alongi, Nicoletta, Pisati, Federica, Giannattasio, Michele, Casagrande, Francesca, Veghini, Lisa, Corbo, Vincenzo, Tripodo, Claudio, Di Napoli, Arianna, Matafora, Vittoria, Bachi, Angela
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.01.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 101/28; 13/109; 13/89; 13/95; 14/19; 38/77; 631/45/475; 631/67/327; 631/80/86; 82; 82/58; 82/83; 96/106; Adenocarcinoma; Agrin; Amyloid; Antibodies; Biochemistry; Biomedical and Life Sciences; Cancer; Cell Biology; Cell Culture; Cell migration; Drug resistance; Ecosystem; Fibrils; Humans; Immunology; Kinases; Life Sciences; Melanoma; Pancreatic Neoplasms - genetics; Secretome; Signal Transduction; Transcription activation; Tumor Microenvironment; Tumors; Yes-associated protein

The tumor microenvironment is a complex ecosystem that plays a critical role in cancer progression and treatment response. Recently, extracellular amyloid fibrils have emerged as novel components of the tumor microenvironment; however, their function remains elusive. In this study, we establish a di...