Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers

Fascin is an actin-bundling protein that is critical for filopodial formation and other cellular cytoskeletal structures. An elevated expression of fascin has been observed in tumor cells and is correlated with a shorter survival of cancer patients. Given its roles in tumor cell migration and invasi...

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Published inCancers Vol. 12; no. 8; p. 2287
Main Authors Wang, Yufeng, Zhang, J. Jillian, Huang, Xin-Yun
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2020
MDPI
Subjects
Actin
B-cell lymphoma
Binding sites
Breast cancer
Cancer
Cancer therapies
Cell adhesion & migration
Cell migration
Chemotherapy
Cytoskeleton
Drug dosages
Epidermal growth factor
Epidermal growth factor receptors
fascin
Lungs
Lymphocytes B
Lymphoma
Medical prognosis
Metastases
Metastasis
Pharmacokinetics
Physiological aspects
Tumor cells
tumor metastasis
Tumors
United States
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Abstract Fascin is an actin-bundling protein that is critical for filopodial formation and other cellular cytoskeletal structures. An elevated expression of fascin has been observed in tumor cells and is correlated with a shorter survival of cancer patients. Given its roles in tumor cell migration and invasion, we have developed small-molecule fascin inhibitors to prevent and delay tumor metastasis. Here we report the characterization of a new fascin inhibitor in mice. In addition to its inhibitory effects on tumor metastasis, we also report that fascin inhibitors can decrease the growth of specific subtypes of cancers, including epidermal growth factor receptor (EGFR)-high triple-negative breast cancer, and activated B-cell subtypes of diffuse large B-cell lymphoma. Hence, fascin inhibitors can be used to not only inhibit tumor metastasis, but also decrease the tumor growth of specific cancer types.
AbstractList Fascin is an actin-bundling protein that is critical for filopodial formation and other cellular cytoskeletal structures. An elevated expression of fascin has been observed in tumor cells and is correlated with a shorter survival of cancer patients. Given its roles in tumor cell migration and invasion, we have developed small-molecule fascin inhibitors to prevent and delay tumor metastasis. Here we report the characterization of a new fascin inhibitor in mice. In addition to its inhibitory effects on tumor metastasis, we also report that fascin inhibitors can decrease the growth of specific subtypes of cancers, including epidermal growth factor receptor (EGFR)-high triple-negative breast cancer, and activated B-cell subtypes of diffuse large B-cell lymphoma. Hence, fascin inhibitors can be used to not only inhibit tumor metastasis, but also decrease the tumor growth of specific cancer types.
Audience Academic
Author Zhang, J. Jillian
Huang, Xin-Yun
Wang, Yufeng
AuthorAffiliation 3 Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA
1 Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA; yuw2007@med.cornell.edu
2 Novita Pharmaceuticals, Inc., New York, NY 10065, USA; jzhang1161@gmail.com
AuthorAffiliation_xml – name: 2 Novita Pharmaceuticals, Inc., New York, NY 10065, USA; jzhang1161@gmail.com
– name: 3 Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA
– name: 1 Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA; yuw2007@med.cornell.edu
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Cites_doi 10.1073/pnas.1008969108
10.1053/j.gastro.2014.01.046
10.1016/j.jmb.2018.03.009
10.1016/j.celrep.2015.03.050
10.1016/j.biocel.2005.05.004
10.1016/j.tibs.2019.11.003
10.1111/j.1432-1033.1970.tb01016.x
10.1242/jcs.100.3.491
10.1101/pdb.prot083733
10.1016/j.ccr.2008.12.019
10.1074/jbc.271.12.6861
10.1054/bjoc.2000.1395
10.1016/j.ejcb.2014.08.002
10.18632/oncotarget.12284
10.1038/nm.4341
10.1016/S0021-9258(18)89183-9
10.1126/science.1175862
10.1038/nature08978
10.1038/nrm2406
10.1091/mbc.E14-09-1384
10.1158/1078-0432.CCR-08-1789
10.1016/0022-2836(78)90345-5
10.1002/cm.20356
10.1158/1078-0432.CCR-05-2281
10.1146/annurev.cellbio.21.122303.120306
10.1126/scisignal.aas9473
10.1038/nrc1098
10.1016/0092-8674(79)90154-5
10.1073/pnas.0500658102
10.1038/ncomms8465
10.4161/cib.3.3.11556
10.1016/0014-4827(92)90465-K
10.1007/s11912-017-0593-6
10.1529/biophysj.104.056515
10.1016/j.cell.2011.09.024
10.1016/j.devcel.2016.07.021
10.1126/scisignal.aaq1060
10.1016/S0169-5002(03)00294-0
10.1083/jcb.119.2.349
10.1186/1741-7015-11-52
10.1172/JCI71812
10.1023/A:1018943613122
10.1158/1078-0432.CCR-14-0384
10.1023/A:1010623111204
10.1016/j.molonc.2016.03.006
10.1126/scisignal.aan0949
10.1371/journal.pone.0027339
10.1083/jcb.200208059
10.1159/000081327
10.3892/ol.2015.3522
10.1016/j.cell.2015.12.042
10.1083/jcb.200603013
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References Arnold (ref_52) 1970; 15
Fidler (ref_34) 2003; 3
Coopman (ref_39) 1998; 4
ref_12
Huang (ref_20) 2018; 430
ref_55
Cao (ref_9) 2005; 24
Condeelis (ref_36) 2005; 21
Rickman (ref_43) 2017; 23
Wang (ref_53) 1996; 271
Hashimoto (ref_8) 2004; 67
Hashimoto (ref_14) 2005; 37
Mattila (ref_38) 2008; 9
Otto (ref_1) 1979; 17
Cifuentes (ref_56) 2015; 10
Grothey (ref_13) 2000; 83
Pinkus (ref_26) 1997; 150
Huang (ref_18) 2015; 6
Vlachostergios (ref_42) 2017; 19
Pelosi (ref_7) 2003; 42
Sarrio (ref_10) 2006; 12
Moujaber (ref_50) 2020; 45
Wang (ref_54) 2014; 124
Vignjevic (ref_4) 2003; 160
Li (ref_16) 2014; 146
Chen (ref_24) 2010; 464
Han (ref_19) 2016; 10
Deng (ref_28) 2015; 21
Jayo (ref_46) 2016; 38
Schoumacher (ref_17) 2014; 93
Roth (ref_48) 2018; 11
ref_33
Valastyan (ref_35) 2011; 147
Romeyn (ref_31) 1992; 199
Pollard (ref_37) 2009; 326
Yamakita (ref_15) 2009; 66
Rijken (ref_30) 1991; 100
Verkleij (ref_32) 1992; 119
Shan (ref_22) 2005; 102
Bryan (ref_2) 1978; 125
Groen (ref_45) 2015; 26
Vignjevic (ref_5) 2006; 174
Yang (ref_23) 2009; 15
ref_44
McClatchey (ref_47) 2018; 11
Matsumura (ref_3) 1985; 260
Pulaski (ref_25) 1998; 58
Mogilner (ref_40) 2005; 89
Darnel (ref_6) 2009; 15
Davies (ref_21) 1993; 10
Pike (ref_49) 2018; 11
Hu (ref_51) 2016; 164
Lawrence (ref_29) 2015; 11
Yao (ref_41) 2017; 8
Kloo (ref_27) 2011; 108
Machesky (ref_11) 2010; 3
References_xml – volume: 108
  start-page: 272
  year: 2011
  ident: ref_27
  article-title: Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1008969108
  contributor:
    fullname: Kloo
– volume: 146
  start-page: 1386
  year: 2014
  ident: ref_16
  article-title: Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2014.01.046
  contributor:
    fullname: Li
– volume: 430
  start-page: 1324
  year: 2018
  ident: ref_20
  article-title: Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2018.03.009
  contributor:
    fullname: Huang
– volume: 11
  start-page: 630
  year: 2015
  ident: ref_29
  article-title: The proteomic landscape of triple-negative breast cancer
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.03.050
  contributor:
    fullname: Lawrence
– volume: 37
  start-page: 1787
  year: 2005
  ident: ref_14
  article-title: Roles of fascin in human carcinoma motility and signaling: Prospects for a novel biomarker?
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2005.05.004
  contributor:
    fullname: Hashimoto
– volume: 45
  start-page: 96
  year: 2020
  ident: ref_50
  article-title: The Cytoskeleton as Regulator of Cell Signaling Pathways
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2019.11.003
  contributor:
    fullname: Moujaber
– volume: 15
  start-page: 360
  year: 1970
  ident: ref_52
  article-title: Binding of aldolase and triosephosphate dehydrogenase to F-actin and modification of catalytic properties of aldolase
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1970.tb01016.x
  contributor:
    fullname: Arnold
– volume: 100
  start-page: 491
  year: 1991
  ident: ref_30
  article-title: Epidermal growth factor induces rapid reorganization of the actin microfilament system in human A431 cells
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.100.3.491
  contributor:
    fullname: Rijken
– volume: 24
  start-page: 67
  year: 2005
  ident: ref_9
  article-title: Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas in the ovary
  publication-title: Int. J. Gynecol. Pathol.
  contributor:
    fullname: Cao
– ident: ref_55
  doi: 10.1101/pdb.prot083733
– volume: 15
  start-page: 124
  year: 2009
  ident: ref_23
  article-title: Orai1 and STIM1 are critical for breast tumor cell migration and metastasis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2008.12.019
  contributor:
    fullname: Yang
– volume: 58
  start-page: 1486
  year: 1998
  ident: ref_25
  article-title: Reduction of established spontaneous mammary carcinoma metastases following immunotherapy with major histocompatibility complex class II and B7.1 cell-based tumor vaccines
  publication-title: Cancer Res.
  contributor:
    fullname: Pulaski
– volume: 271
  start-page: 6861
  year: 1996
  ident: ref_53
  article-title: The molecular nature of the F-actin binding activity of aldolase revealed with site-directed mutants
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.12.6861
  contributor:
    fullname: Wang
– volume: 83
  start-page: 870
  year: 2000
  ident: ref_13
  article-title: Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer
  publication-title: Br. J. Cancer
  doi: 10.1054/bjoc.2000.1395
  contributor:
    fullname: Grothey
– volume: 93
  start-page: 388
  year: 2014
  ident: ref_17
  article-title: Conditional expression of fascin increases tumor progression in a mouse model of intestinal cancer
  publication-title: Eur. J. Cell Biol.
  doi: 10.1016/j.ejcb.2014.08.002
  contributor:
    fullname: Schoumacher
– volume: 8
  start-page: 1913
  year: 2017
  ident: ref_41
  article-title: Triple-negative breast cancer: Is there a treatment on the horizon?
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12284
  contributor:
    fullname: Yao
– volume: 23
  start-page: 1
  year: 2017
  ident: ref_43
  article-title: Biology and evolution of poorly differentiated neuroendocrine tumors
  publication-title: Nat. Med.
  doi: 10.1038/nm.4341
  contributor:
    fullname: Rickman
– volume: 260
  start-page: 5087
  year: 1985
  ident: ref_3
  article-title: Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)89183-9
  contributor:
    fullname: Matsumura
– volume: 150
  start-page: 543
  year: 1997
  ident: ref_26
  article-title: Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin’s disease. Evidence for a dendritic or B cell derivation?
  publication-title: Am. J. Pathol.
  contributor:
    fullname: Pinkus
– volume: 326
  start-page: 1208
  year: 2009
  ident: ref_37
  article-title: Actin, a central player in cell shape and movement
  publication-title: Science
  doi: 10.1126/science.1175862
  contributor:
    fullname: Pollard
– volume: 464
  start-page: 1062
  year: 2010
  ident: ref_24
  article-title: Migrastatin analogues target fascin to block tumour metastasis
  publication-title: Nature
  doi: 10.1038/nature08978
  contributor:
    fullname: Chen
– volume: 9
  start-page: 446
  year: 2008
  ident: ref_38
  article-title: Filopodia: Molecular architecture and cellular functions
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2406
  contributor:
    fullname: Mattila
– volume: 26
  start-page: 1901
  year: 2015
  ident: ref_45
  article-title: Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E14-09-1384
  contributor:
    fullname: Groen
– volume: 15
  start-page: 1376
  year: 2009
  ident: ref_6
  article-title: Fascin regulates prostate cancer cell invasion and is associated with metastasis and biochemical failure in prostate cancer
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-08-1789
  contributor:
    fullname: Darnel
– volume: 125
  start-page: 207
  year: 1978
  ident: ref_2
  article-title: Separation and interaction of the major components of sea urchin actin gel
  publication-title: J. Mol. Biol.
  doi: 10.1016/0022-2836(78)90345-5
  contributor:
    fullname: Bryan
– volume: 66
  start-page: 524
  year: 2009
  ident: ref_15
  article-title: Fascin1 is dispensable for mouse development but is favorable for neonatal survival
  publication-title: Cell Motil. Cytoskeleton
  doi: 10.1002/cm.20356
  contributor:
    fullname: Yamakita
– volume: 12
  start-page: 1533
  year: 2006
  ident: ref_10
  article-title: Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-05-2281
  contributor:
    fullname: Sarrio
– volume: 21
  start-page: 695
  year: 2005
  ident: ref_36
  article-title: The great escape: When cancer cells hijack the genes for chemotaxis and motility
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev.cellbio.21.122303.120306
  contributor:
    fullname: Condeelis
– volume: 11
  start-page: eaas9473
  year: 2018
  ident: ref_47
  article-title: EGFR-induced cytoskeletal changes drive complex cell behaviors: The tip of the iceberg
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aas9473
  contributor:
    fullname: McClatchey
– volume: 3
  start-page: 453
  year: 2003
  ident: ref_34
  article-title: The pathogenesis of cancer metastasis: The ‘seed and soil’ hypothesis revisited
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1098
  contributor:
    fullname: Fidler
– volume: 17
  start-page: 285
  year: 1979
  ident: ref_1
  article-title: Formation of filopodia in coelomocytes: Localization of fascin, a 58,000 dalton actin cross-linking protein
  publication-title: Cell
  doi: 10.1016/0092-8674(79)90154-5
  contributor:
    fullname: Otto
– volume: 102
  start-page: 3772
  year: 2005
  ident: ref_22
  article-title: Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0500658102
  contributor:
    fullname: Shan
– volume: 6
  start-page: 7465
  year: 2015
  ident: ref_18
  article-title: Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8465
  contributor:
    fullname: Huang
– volume: 3
  start-page: 263
  year: 2010
  ident: ref_11
  article-title: Fascin: Invasive filopodia promoting metastasis
  publication-title: Commun. Integr. Biol.
  doi: 10.4161/cib.3.3.11556
  contributor:
    fullname: Machesky
– volume: 199
  start-page: 90
  year: 1992
  ident: ref_31
  article-title: The epidermal growth factor receptor is associated with actin filaments
  publication-title: Exp. Cell Res.
  doi: 10.1016/0014-4827(92)90465-K
  contributor:
    fullname: Romeyn
– volume: 19
  start-page: 32
  year: 2017
  ident: ref_42
  article-title: Emerging Variants of Castration-Resistant Prostate Cancer
  publication-title: Curr. Oncol. Rep.
  doi: 10.1007/s11912-017-0593-6
  contributor:
    fullname: Vlachostergios
– volume: 89
  start-page: 782
  year: 2005
  ident: ref_40
  article-title: The physics of filopodial protrusion
  publication-title: Biophys. J.
  doi: 10.1529/biophysj.104.056515
  contributor:
    fullname: Mogilner
– volume: 147
  start-page: 275
  year: 2011
  ident: ref_35
  article-title: Tumor metastasis: Molecular insights and evolving paradigms
  publication-title: Cell
  doi: 10.1016/j.cell.2011.09.024
  contributor:
    fullname: Valastyan
– volume: 38
  start-page: 371
  year: 2016
  ident: ref_46
  article-title: Fascin Regulates Nuclear Movement and Deformation in Migrating Cells
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2016.07.021
  contributor:
    fullname: Jayo
– volume: 11
  start-page: eaaq1060
  year: 2018
  ident: ref_49
  article-title: KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aaq1060
  contributor:
    fullname: Pike
– volume: 42
  start-page: 203
  year: 2003
  ident: ref_7
  article-title: Independent value of fascin immunoreactivity for predicting lymph node metastases in typical and atypical pulmonary carcinoids
  publication-title: Lung Cancer
  doi: 10.1016/S0169-5002(03)00294-0
  contributor:
    fullname: Pelosi
– volume: 119
  start-page: 349
  year: 1992
  ident: ref_32
  article-title: The EGF receptor is an actin-binding protein
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.119.2.349
  contributor:
    fullname: Verkleij
– ident: ref_12
  doi: 10.1186/1741-7015-11-52
– volume: 124
  start-page: 1646
  year: 2014
  ident: ref_54
  article-title: DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI71812
  contributor:
    fullname: Wang
– volume: 10
  start-page: 1093
  year: 1993
  ident: ref_21
  article-title: Physiological parameters in laboratory animals and humans
  publication-title: Pharm. Res.
  doi: 10.1023/A:1018943613122
  contributor:
    fullname: Davies
– volume: 21
  start-page: 134
  year: 2015
  ident: ref_28
  article-title: The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-kappaB
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-14-0384
  contributor:
    fullname: Deng
– ident: ref_33
  doi: 10.1023/A:1010623111204
– volume: 10
  start-page: 966
  year: 2016
  ident: ref_19
  article-title: Improving fascin inhibitors to block tumor cell migration and metastasis
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2016.03.006
  contributor:
    fullname: Han
– volume: 11
  start-page: eaan0949
  year: 2018
  ident: ref_48
  article-title: SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aan0949
  contributor:
    fullname: Roth
– ident: ref_44
  doi: 10.1371/journal.pone.0027339
– volume: 4
  start-page: 507
  year: 1998
  ident: ref_39
  article-title: Phagocytosis of cross-linked gelatin matrix by human breast carcinoma cells correlates with their invasive capacity
  publication-title: Clin. Cancer Res.
  contributor:
    fullname: Coopman
– volume: 160
  start-page: 951
  year: 2003
  ident: ref_4
  article-title: Formation of filopodia-like bundles in vitro from a dendritic network
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200208059
  contributor:
    fullname: Vignjevic
– volume: 67
  start-page: 262
  year: 2004
  ident: ref_8
  article-title: The prognostic relevance of fascin expression in human gastric carcinoma
  publication-title: Oncology
  doi: 10.1159/000081327
  contributor:
    fullname: Hashimoto
– volume: 10
  start-page: 2142
  year: 2015
  ident: ref_56
  article-title: Development of an orthotopic model of human metastatic prostate cancer in the NOD-SCIDgamma mouse (Mus musculus) anterior prostate
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2015.3522
  contributor:
    fullname: Cifuentes
– volume: 164
  start-page: 433
  year: 2016
  ident: ref_51
  article-title: Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
  publication-title: Cell
  doi: 10.1016/j.cell.2015.12.042
  contributor:
    fullname: Hu
– volume: 174
  start-page: 863
  year: 2006
  ident: ref_5
  article-title: Role of fascin in filopodial protrusion
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200603013
  contributor:
    fullname: Vignjevic
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Snippet Fascin is an actin-bundling protein that is critical for filopodial formation and other cellular cytoskeletal structures. An elevated expression of fascin has...
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SubjectTerms Actin
B-cell lymphoma
Binding sites
Breast cancer
Cancer
Cancer therapies
Cell adhesion & migration
Cell migration
Chemotherapy
Cytoskeleton
Drug dosages
Epidermal growth factor
Epidermal growth factor receptors
fascin
Lungs
Lymphocytes B
Lymphoma
Medical prognosis
Metastases
Metastasis
Pharmacokinetics
Physiological aspects
Tumor cells
tumor metastasis
Tumors
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Title Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers
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https://pubmed.ncbi.nlm.nih.gov/PMC7466159
https://doaj.org/article/33f812f2d28c4424a84fd07af022ea23
Volume 12
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