Psmb8 inhibits mitochondrial fission and alleviates myocardial ischaemia/reperfusion injury by targeting Drp1 degradation

• Published in: Cell death & disease Vol. 15; no. 11; pp. 803 - 16
• Main Authors: Su, Hui-Xiang, Xu, Luo-Luo, Li, Pang-Bo, Bi, Hai-Lian, Jiang, Wen-Xi, Li, Hui-Hua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.11.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 14/19; 14/28; 38/1; 38/77; 631/80/304; 64/60; 692/699/75/2/1674; 82/58; 82/80; 96/109; Animals; Antibodies; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cardiomyocytes; Catalytic subunits; Cell Biology; Cell Culture; Coronary artery disease; Dynamin; Dynamins - genetics; Dynamins - metabolism; Heart diseases; Humans; Immunology; Ischemia; Life Sciences; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Dynamics; Myocardial infarction; Myocardial Infarction - genetics; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocardial Reperfusion Injury - genetics; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Proteasome Endopeptidase Complex - metabolism; Proteolysis; Reperfusion

The mitochondrial dynamic imbalance is an important cause of myocardial ischaemia/reperfusion (I/R) injury and dysfunction. Psmb8, as one of the immunoproteasome catalytic subunits, is a key regulator of protein homoeostasis, inflammation and some cardiac diseases. Here, we found that the expression...