The transcriptional legacy of developmental stochasticity

• Published in: Nature communications Vol. 14; no. 1; p. 7226
• Main Authors: Ballouz, Sara, Kawaguchi, Risa Karakida, Pena, Maria T., Fischer, Stephan, Crow, Megan, French, Leon, Knight, Frank M., Adams, Linda B., Gillis, Jesse
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 38; 38/91; 45; 45/91; 631/136; 631/208/176; 631/208/199; Alleles; Animals; Armadillos - physiology; DNA methylation; Environmental factors; Epigenetics; Gene expression; Genetic diversity; Genetics; Genomics; Humanities and Social Sciences; Humans; Inactivation; multidisciplinary; Penetrance; Perturbation; Phenotype; Phenotypes; Science; Science (multidisciplinary); Stochasticity; Transcriptomes; Variability; X chromosomes

Genetic and environmental variation are key contributors during organism development, but the influence of minor perturbations or noise is difficult to assess. This study focuses on the stochastic variation in allele-specific expression that persists through cell divisions in the nine-banded armadil...