IntDOT Interactions with Core Sites during Integrative Recombination

• Published in: Journal of Bacteriology Vol. 195; no. 9; pp. 1883 - 1891
• Main Authors: Laprise, Jennifer, Yoneji, Sumiko, Gardner, Jeffrey F
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.05.2013
• Subjects: antibiotic resistance; Antibiotics; Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Bacteroides; Bacteroides - enzymology; Bacteroides - genetics; Bacteroides - physiology; Base Sequence; Chromosomes; Conjugation, Genetic; erythromycin; Genes; Integrases - genetics; Integrases - metabolism; Molecular Sequence Data; Mutation; Recombination, Genetic; tetracycline; transposons; tyrosine

Integrative and conjugative elements (ICEs), formerly called conjugative transposons, have been implicated in the proliferation of antibiotic resistance genes. CTnDOT is an extensively studied ICE found in Bacteroides spp. In addition to carrying resistance genes to both erythromycin and tetracyclin...