Lesion probability mapping to explain clinical deficits and cognitive performance in multiple sclerosis

• Published in: Multiple sclerosis Vol. 17; no. 6; pp. 681 - 689
• Main Authors: Kincses, ZT, Ropele, S, Jenkinson, M, Khalil, M, Petrovic, K, Loitfelder, M, Langkammer, C, Aspeck, E, Wallner-Blazek, M, Fuchs, S, Jehna, M, Schmidt, R, Vécsei, L, Fazekas, F, Enzinger, C
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.06.2011; Sage Publications; Sage Publications Ltd
• Subjects: Adult; Attention; Austria; Biological and medical sciences; Brain - pathology; Brain Mapping - methods; Cerebellum; Cognition; Cognitive ability; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Demyelinating Diseases - diagnosis; Demyelinating Diseases - pathology; Demyelinating Diseases - psychology; Diffusion Magnetic Resonance Imaging; Disability Evaluation; Executive Function; Female; Humans; Magnetic resonance imaging; Male; Mapping; Medical sciences; Memory; Middle Aged; Multiple sclerosis; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple Sclerosis, Chronic Progressive - diagnosis; Multiple Sclerosis, Chronic Progressive - pathology; Multiple Sclerosis, Chronic Progressive - psychology; Multiple Sclerosis, Relapsing-Remitting - diagnosis; Multiple Sclerosis, Relapsing-Remitting - pathology; Multiple Sclerosis, Relapsing-Remitting - psychology; Neurology; Neuropsychological Tests; Predictive Value of Tests; Severity of Illness Index; Thalamus; Time Factors; Verbal Behavior; Austria; cognition; verbal fluency; MRI; lesion symptom mapping; disability; multiple sclerosis; Cartography; Nervous system diseases; Multiple sclerosis; Cognitive disorder; Probability; Cognition; Nuclear magnetic resonance imaging; Inflammatory disease; Disability; Central nervous system disease; Degenerative disease; Performance

Background: Lesion dissemination in time and space represents a key feature and diagnostic marker of multiple sclerosis (MS). The correlation between magnetic resonance imaging (MRI) lesion load and disability is only modest, however. Strategic lesion location might at least partially account for th...