Animal Pneumoviruses: Molecular Genetics and Pathogenesis

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Published inClinical Microbiology Reviews Vol. 17; no. 2; pp. 390 - 412
Main Authors Easton, Andrew J., Domachowske, Joseph B., Rosenberg, Helene F.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.2004
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Abstract Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CMR About CMR Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CMR RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0893-8512 Online ISSN: 1098-6618 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CMR .asm.org, visit: CMR       
AbstractList Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that infect humans (respiratory syncytial virus and human metapneumovirus), domestic mammals (bovine, ovine, and caprine respiratory syncytial viruses), rodents (pneumonia virus of mice), and birds (avian metapneumovirus). Among the topics considered in this review are recent studies focused on the roles of the individual virus-encoded components in promoting virus replication as well as in altering and evading innate antiviral host defenses. Advances in the molecular technology of pneumoviruses and the emergence of recombinant pneumoviruses that are leading to improved virus-based vaccine formulations are also discussed. Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, we also review the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches.
Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae , subfamily Pneumovirinae , and include pathogens that infect humans (respiratory syncytial virus and human metapneumovirus), domestic mammals (bovine, ovine, and caprine respiratory syncytial viruses), rodents (pneumonia virus of mice), and birds (avian metapneumovirus). Among the topics considered in this review are recent studies focused on the roles of the individual virus-encoded components in promoting virus replication as well as in altering and evading innate antiviral host defenses. Advances in the molecular technology of pneumoviruses and the emergence of recombinant pneumoviruses that are leading to improved virus-based vaccine formulations are also discussed. Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, we also review the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches.
Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that infect humans (respiratory syncytial virus and human metapneumovirus), domestic mammals (bovine, ovine, and caprine respiratory syncytial viruses), rodents (pneumonia virus of mice), and birds (avian metapneumovirus). Among the topics considered in this review are recent studies focused on the roles of the individual virus-encoded components in promoting virus replication as well as in altering and evading innate antiviral host defenses. Advances in the molecular technology of pneumoviruses and the emergence of recombinant pneumoviruses that are leading to improved virus-based vaccine formulations are also discussed. Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, we also review the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches.Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that infect humans (respiratory syncytial virus and human metapneumovirus), domestic mammals (bovine, ovine, and caprine respiratory syncytial viruses), rodents (pneumonia virus of mice), and birds (avian metapneumovirus). Among the topics considered in this review are recent studies focused on the roles of the individual virus-encoded components in promoting virus replication as well as in altering and evading innate antiviral host defenses. Advances in the molecular technology of pneumoviruses and the emergence of recombinant pneumoviruses that are leading to improved virus-based vaccine formulations are also discussed. Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, we also review the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches.
Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CMR About CMR Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CMR RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0893-8512 Online ISSN: 1098-6618 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CMR .asm.org, visit: CMR       
Author Helene F. Rosenberg
Andrew J. Easton
Joseph B. Domachowske
AuthorAffiliation University of Warwick, Coventry, United Kingdom, 1 State University of New York Upstate Medical University, Syracuse, New York, 2 Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 3
AuthorAffiliation_xml – name: University of Warwick, Coventry, United Kingdom, 1 State University of New York Upstate Medical University, Syracuse, New York, 2 Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 3
Author_xml – sequence: 1
  givenname: Andrew J.
  surname: Easton
  fullname: Easton, Andrew J.
  organization: University of Warwick, Coventry, United Kingdom, State University of New York Upstate Medical University, Syracuse, New York, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
– sequence: 2
  givenname: Joseph B.
  surname: Domachowske
  fullname: Domachowske, Joseph B.
  organization: University of Warwick, Coventry, United Kingdom, State University of New York Upstate Medical University, Syracuse, New York, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
– sequence: 3
  givenname: Helene F.
  surname: Rosenberg
  fullname: Rosenberg, Helene F.
  organization: University of Warwick, Coventry, United Kingdom, State University of New York Upstate Medical University, Syracuse, New York, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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https://www.ncbi.nlm.nih.gov/pubmed/15084507$$D View this record in MEDLINE/PubMed
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Corresponding author. Mailing address: Building 10, Room 11N104, Laboratory of Allergic Diseases, NIAID, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892. Phone: (301) 402-1545. Fax: (301) 402-4369. E-mail: hrosenberg@niaid.nih.gov.
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Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that...
Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae , subfamily Pneumovirinae , and include pathogens...
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SubjectTerms Animals
Antiviral Agents - therapeutic use
Biological and medical sciences
Cattle
Cell Line
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
History, 15th Century
Human metapneumovirus
Humans
Infectious diseases
Medical sciences
Microbiology
Paramyxoviridae Infections - drug therapy
Paramyxoviridae Infections - physiopathology
Paramyxoviridae Infections - virology
Pneumovirinae - classification
Pneumovirinae - genetics
Pneumovirinae - pathogenicity
Respiratory syncytial virus
Review
Title Animal Pneumoviruses: Molecular Genetics and Pathogenesis
URI http://cmr.asm.org/content/17/2/390.abstract
https://www.ncbi.nlm.nih.gov/pubmed/15084507
https://www.proquest.com/docview/17942175
https://www.proquest.com/docview/71832427
https://pubmed.ncbi.nlm.nih.gov/PMC387412
Volume 17
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