Animal Pneumoviruses: Molecular Genetics and Pathogenesis
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Published in | Clinical Microbiology Reviews Vol. 17; no. 2; pp. 390 - 412 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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American Society for Microbiology
01.04.2004
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AbstractList | Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that infect humans (respiratory syncytial virus and human metapneumovirus), domestic mammals (bovine, ovine, and caprine respiratory syncytial viruses), rodents (pneumonia virus of mice), and birds (avian metapneumovirus). Among the topics considered in this review are recent studies focused on the roles of the individual virus-encoded components in promoting virus replication as well as in altering and evading innate antiviral host defenses. Advances in the molecular technology of pneumoviruses and the emergence of recombinant pneumoviruses that are leading to improved virus-based vaccine formulations are also discussed. Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, we also review the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches. Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae , subfamily Pneumovirinae , and include pathogens that infect humans (respiratory syncytial virus and human metapneumovirus), domestic mammals (bovine, ovine, and caprine respiratory syncytial viruses), rodents (pneumonia virus of mice), and birds (avian metapneumovirus). Among the topics considered in this review are recent studies focused on the roles of the individual virus-encoded components in promoting virus replication as well as in altering and evading innate antiviral host defenses. Advances in the molecular technology of pneumoviruses and the emergence of recombinant pneumoviruses that are leading to improved virus-based vaccine formulations are also discussed. Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, we also review the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches. Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that infect humans (respiratory syncytial virus and human metapneumovirus), domestic mammals (bovine, ovine, and caprine respiratory syncytial viruses), rodents (pneumonia virus of mice), and birds (avian metapneumovirus). Among the topics considered in this review are recent studies focused on the roles of the individual virus-encoded components in promoting virus replication as well as in altering and evading innate antiviral host defenses. Advances in the molecular technology of pneumoviruses and the emergence of recombinant pneumoviruses that are leading to improved virus-based vaccine formulations are also discussed. Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, we also review the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches.Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that infect humans (respiratory syncytial virus and human metapneumovirus), domestic mammals (bovine, ovine, and caprine respiratory syncytial viruses), rodents (pneumonia virus of mice), and birds (avian metapneumovirus). Among the topics considered in this review are recent studies focused on the roles of the individual virus-encoded components in promoting virus replication as well as in altering and evading innate antiviral host defenses. Advances in the molecular technology of pneumoviruses and the emergence of recombinant pneumoviruses that are leading to improved virus-based vaccine formulations are also discussed. Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, we also review the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches. Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CMR About CMR Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CMR RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0893-8512 Online ISSN: 1098-6618 Copyright © 2014 by the American Society for Microbiology. For an alternate route to CMR .asm.org, visit: CMR |
Author | Helene F. Rosenberg Andrew J. Easton Joseph B. Domachowske |
AuthorAffiliation | University of Warwick, Coventry, United Kingdom, 1 State University of New York Upstate Medical University, Syracuse, New York, 2 Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 3 |
AuthorAffiliation_xml | – name: University of Warwick, Coventry, United Kingdom, 1 State University of New York Upstate Medical University, Syracuse, New York, 2 Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 3 |
Author_xml | – sequence: 1 givenname: Andrew J. surname: Easton fullname: Easton, Andrew J. organization: University of Warwick, Coventry, United Kingdom, State University of New York Upstate Medical University, Syracuse, New York, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland – sequence: 2 givenname: Joseph B. surname: Domachowske fullname: Domachowske, Joseph B. organization: University of Warwick, Coventry, United Kingdom, State University of New York Upstate Medical University, Syracuse, New York, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland – sequence: 3 givenname: Helene F. surname: Rosenberg fullname: Rosenberg, Helene F. organization: University of Warwick, Coventry, United Kingdom, State University of New York Upstate Medical University, Syracuse, New York, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15694443$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15084507$$D View this record in MEDLINE/PubMed |
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Reddit... Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that... Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae , subfamily Pneumovirinae , and include pathogens... |
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SubjectTerms | Animals Antiviral Agents - therapeutic use Biological and medical sciences Cattle Cell Line Disease Models, Animal Fundamental and applied biological sciences. Psychology History, 15th Century Human metapneumovirus Humans Infectious diseases Medical sciences Microbiology Paramyxoviridae Infections - drug therapy Paramyxoviridae Infections - physiopathology Paramyxoviridae Infections - virology Pneumovirinae - classification Pneumovirinae - genetics Pneumovirinae - pathogenicity Respiratory syncytial virus Review |
Title | Animal Pneumoviruses: Molecular Genetics and Pathogenesis |
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