ACSL4-mediated lipid rafts prevent membrane rupture and inhibit immunogenic cell death in melanoma

• Published in: Cell death & disease Vol. 15; no. 9; pp. 695 - 15
• Main Authors: Zhao, Xi, Zhao, Zenglu, Li, Bingru, Huan, Shuyu, Li, Zixi, Xie, Jianlan, Liu, Guoquan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.09.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 101/58; 13/31; 13/89; 14/19; 38/91; 692/699/67/1059/99; 692/699/67/2327; 692/699/67/327; 82/51; 82/80; Animals; Antibodies; Antitumor activity; Biochemistry; Biomedical and Life Sciences; CD8 antigen; Cell Biology; Cell Culture; Cell death; Cell Line, Tumor; Cell membranes; Chemotherapy; Cholesterol; Coenzyme A Ligases - metabolism; Drugs; Ferroptosis; Ferroptosis - drug effects; Humans; Immune checkpoint inhibitors; Immunity; Immunogenic Cell Death - drug effects; Immunogenicity; Immunology; Immunosuppressive agents; Life Sciences; Lipid peroxidation; Lipid Peroxidation - drug effects; Lipid rafts; Lipids; Lymphocytes T; Melanoma; Melanoma - drug therapy; Melanoma - immunology; Melanoma - pathology; Membrane Microdomains - drug effects; Membrane Microdomains - metabolism; Mice; Mice, Inbred C57BL; Platinum; Pyroptosis; Pyroptosis - drug effects; Tumor microenvironment; Tumor Microenvironment - drug effects

Chemotherapy including platinum-based drugs are a possible strategy to enhance the immune response in advanced melanoma patients who are resistant to immune checkpoint blockade (ICB) therapy. However, the immune-boosting effects of these drugs are a subject of controversy, and their impact on the tu...