Multiscale, mechanistic model of Rheumatoid Arthritis to enable decision making in late stage drug development - Bedathuru, Dinesh; Rengaswamy, Maithreye; Channavazzala, Madhav; Ray, Tamara; Packrisamy, Prakash; Kumar, Rukmini (NPJ systems biology and applications, 2024)
Keywords: 631/250; 631/553/2696; Adalimumab - therapeutic use; Antibodies, Monoclonal, Humanized - pharmacology; Antibodies, Monoclonal, Humanized - therapeutic use; Antirheumatic Agents - pharmacology; Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Autoimmune diseases; Bioinformatics; Biomedical and Life Sciences; Clinical trials; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Decision Making; Drug development; Drug Development - methods; Humans; Inflammatory diseases; Life Sciences; Methotrexate; Methotrexate - therapeutic use; Models, Biological; Monoclonal antibodies; Rheumatoid arthritis; Rheumatology; Systems Biology; Tumor necrosis factor-α