Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade - Chen, Chun-Bing; Hung, Shuen-Iu; Chang, John Wen-Cheng; Yang, Chan-Keng; Ma, David Hui-Kang; Teng, Yu-Chuan; Lu, Chun-Wei; Chen, Wei-Ti; Yang, Hsiao-Yin; Tsai, Cheng-Chang; Wang, Chih Liang; Chiang, Pin-Hsuan; et al. (Nature communications, 2024)
Keywords: 13/106; 13/95; 38/39; 38/90; 38/91; 49/47; 631/250/249/1313; 631/250/2502; 631/250/580; 692/53/2423; 692/699/4033; 82/51; 96/21; 96/31; Aged; Antineoplastic drugs; Blistering; Cell activation; Cell differentiation; Chemokine CXCL10 - metabolism; Corticoids; Corticosteroids; CXCL10 protein; CXCR3 protein; Cytotoxicity; Female; Gene sequencing; Humanities and Social Sciences; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - adverse effects; Lesions; Lymphocytes; Lymphocytes T; Macrophages; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Male; Middle Aged; Monocytes; multidisciplinary; Pathogenesis; Receptors, CXCR3 - metabolism; Science; Science (multidisciplinary); Side effects; Single-Cell Analysis; Skin - drug effects; Skin - immunology; Skin - pathology; Skin diseases; Skin lesions; Stevens-Johnson syndrome; Stevens-Johnson Syndrome - etiology; Stevens-Johnson Syndrome - immunology; Stevens-Johnson Syndrome - pathology; T-Lymphocytes, Cytotoxic - drug effects; T-Lymphocytes, Cytotoxic - immunology; Therapeutic targets; Therapy; Toxic epidermal necrolysis; Trajectory analysis; Transcriptomics; Tumor Necrosis Factor Inhibitors - adverse effects; Tumor Necrosis Factor-alpha - metabolism