Real-time monitoring of mitochondrial oxygenation during machine perfusion using resonance Raman spectroscopy predicts organ function

• Published in: Scientific reports Vol. 14; no. 1; p. 7328
• Main Authors: Jain, Rohil, Ajenu, Emmanuella O., Lopera Higuita, Manuela, Hafiz, Ehab O. A., Muzikansky, Alona, Romfh, Padraic, Tessier, Shannon N.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.03.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/61/32; 692/308/575; 692/4020/4021/288; Cold; Cryopreservation; Humanities and Social Sciences; Humans; Ischemia; Liver - metabolism; Liver Transplantation - methods; Mitochondria; multidisciplinary; Organ Preservation - methods; Oxidation; Oxygenation; Perfusion; Perfusion - methods; Raman spectroscopy; Reperfusion; Resonance; Science; Science (multidisciplinary); Spectroscopy; Spectrum analysis; Spectrum Analysis, Raman; Transplantation; Transplants & implants

Organ transplantation is a life-saving procedure affecting over 100,000 people on the transplant waitlist. Ischemia reperfusion injury (IRI) is a major challenge in the field as it can cause post-transplantation complications and limit the use of organs from extended criteria donors. Machine perfusi...