In vivo transplantation of mammalian vascular organoids onto the chick chorioallantoic membrane reveals the formation of a hierarchical vascular network

The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are often investigated with animal models and perfused microchannels, giving insights into this process. To support these studies and enrich our un...

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Published inScientific reports Vol. 15; no. 1; pp. 7150 - 13
Main Authors Kowalski, William J., Vatti, Shravani, Sakamoto, Tyler, Li, Wenling, Odutola, Sarah Rose, Liu, Chengyu, Chen, Guibin, Boehm, Manfred, Mukouyama, Yoh-suke
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 28.02.2025
Nature Publishing Group
Nature Portfolio
Subjects
631/136/16
631/1647/767/1657
Animal models
Animals
Blood flow
Blood Vessels
Cell survival
Chick Embryo
Chorioallantoic membrane
Chorioallantoic Membrane - blood supply
Embryos
Humanities and Social Sciences
Mice
Morphogenesis
Mouse embryonic stem cells
multidisciplinary
Muscle, Smooth, Vascular - cytology
Myocytes, Smooth Muscle - cytology
Myocytes, Smooth Muscle - metabolism
Neovascularization, Physiologic
Organoid
Organoids
Organoids - cytology
Organoids - transplantation
Pericytes
Pericytes - cytology
Pericytes - metabolism
Progenitor cells
Science
Science (multidisciplinary)
Smooth muscle
Transplantation
Vascular remodeling
Vascular remodeling
Organoid
Chorioallantoic membrane
Mouse embryonic stem cells
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Abstract The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are often investigated with animal models and perfused microchannels, giving insights into this process. To support these studies and enrich our understanding, we demonstrate a complementary approach using vascular organoids. Organoids initially form a primitive endothelial plexus lined with NG2 + /PDGFRβ + mural cell progenitors containing immature pericytes, but there is no formation of large-diameter vessels covered with αSMA + cells containing immature vascular smooth muscle cells (vSMCs). After transplantation to the chick chorioallantoic membrane, the network reorganizes into a branched architecture with large-diameter vessels covered by αSMA + cells. We additionally show that blood flow from the host circulation perfuses the organoid. Compared with the developing skin vasculature in mouse embryos, organoids successfully recapitulate vascular morphogenesis, both in vitro and after transplantation. The model described here presents a further approach to enhance the study of vascular remodeling.
AbstractList The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are often investigated with animal models and perfused microchannels, giving insights into this process. To support these studies and enrich our understanding, we demonstrate a complementary approach using vascular organoids. Organoids initially form a primitive endothelial plexus lined with NG2 + /PDGFRβ + mural cell progenitors containing immature pericytes, but there is no formation of large-diameter vessels covered with αSMA + cells containing immature vascular smooth muscle cells (vSMCs). After transplantation to the chick chorioallantoic membrane, the network reorganizes into a branched architecture with large-diameter vessels covered by αSMA + cells. We additionally show that blood flow from the host circulation perfuses the organoid. Compared with the developing skin vasculature in mouse embryos, organoids successfully recapitulate vascular morphogenesis, both in vitro and after transplantation. The model described here presents a further approach to enhance the study of vascular remodeling.
The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are often investigated with animal models and perfused microchannels, giving insights into this process. To support these studies and enrich our understanding, we demonstrate a complementary approach using vascular organoids. Organoids initially form a primitive endothelial plexus lined with NG2 + /PDGFRβ + mural cell progenitors containing immature pericytes, but there is no formation of large-diameter vessels covered with αSMA + cells containing immature vascular smooth muscle cells (vSMCs). After transplantation to the chick chorioallantoic membrane, the network reorganizes into a branched architecture with large-diameter vessels covered by αSMA + cells. We additionally show that blood flow from the host circulation perfuses the organoid. Compared with the developing skin vasculature in mouse embryos, organoids successfully recapitulate vascular morphogenesis, both in vitro and after transplantation. The model described here presents a further approach to enhance the study of vascular remodeling.
Abstract The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are often investigated with animal models and perfused microchannels, giving insights into this process. To support these studies and enrich our understanding, we demonstrate a complementary approach using vascular organoids. Organoids initially form a primitive endothelial plexus lined with NG2+/PDGFRβ+ mural cell progenitors containing immature pericytes, but there is no formation of large-diameter vessels covered with αSMA+ cells containing immature vascular smooth muscle cells (vSMCs). After transplantation to the chick chorioallantoic membrane, the network reorganizes into a branched architecture with large-diameter vessels covered by αSMA+ cells. We additionally show that blood flow from the host circulation perfuses the organoid. Compared with the developing skin vasculature in mouse embryos, organoids successfully recapitulate vascular morphogenesis, both in vitro and after transplantation. The model described here presents a further approach to enhance the study of vascular remodeling.
The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are often investigated with animal models and perfused microchannels, giving insights into this process. To support these studies and enrich our understanding, we demonstrate a complementary approach using vascular organoids. Organoids initially form a primitive endothelial plexus lined with NG2+/PDGFRβ+ mural cell progenitors containing immature pericytes, but there is no formation of large-diameter vessels covered with αSMA+ cells containing immature vascular smooth muscle cells (vSMCs). After transplantation to the chick chorioallantoic membrane, the network reorganizes into a branched architecture with large-diameter vessels covered by αSMA+ cells. We additionally show that blood flow from the host circulation perfuses the organoid. Compared with the developing skin vasculature in mouse embryos, organoids successfully recapitulate vascular morphogenesis, both in vitro and after transplantation. The model described here presents a further approach to enhance the study of vascular remodeling.The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are often investigated with animal models and perfused microchannels, giving insights into this process. To support these studies and enrich our understanding, we demonstrate a complementary approach using vascular organoids. Organoids initially form a primitive endothelial plexus lined with NG2+/PDGFRβ+ mural cell progenitors containing immature pericytes, but there is no formation of large-diameter vessels covered with αSMA+ cells containing immature vascular smooth muscle cells (vSMCs). After transplantation to the chick chorioallantoic membrane, the network reorganizes into a branched architecture with large-diameter vessels covered by αSMA+ cells. We additionally show that blood flow from the host circulation perfuses the organoid. Compared with the developing skin vasculature in mouse embryos, organoids successfully recapitulate vascular morphogenesis, both in vitro and after transplantation. The model described here presents a further approach to enhance the study of vascular remodeling.
The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are often investigated with animal models and perfused microchannels, giving insights into this process. To support these studies and enrich our understanding, we demonstrate a complementary approach using vascular organoids. Organoids initially form a primitive endothelial plexus lined with NG2 /PDGFRβ mural cell progenitors containing immature pericytes, but there is no formation of large-diameter vessels covered with αSMA cells containing immature vascular smooth muscle cells (vSMCs). After transplantation to the chick chorioallantoic membrane, the network reorganizes into a branched architecture with large-diameter vessels covered by αSMA cells. We additionally show that blood flow from the host circulation perfuses the organoid. Compared with the developing skin vasculature in mouse embryos, organoids successfully recapitulate vascular morphogenesis, both in vitro and after transplantation. The model described here presents a further approach to enhance the study of vascular remodeling.
ArticleNumber 7150
Author Li, Wenling
Chen, Guibin
Kowalski, William J.
Mukouyama, Yoh-suke
Liu, Chengyu
Boehm, Manfred
Vatti, Shravani
Sakamoto, Tyler
Odutola, Sarah Rose
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Issue 1
Keywords Vascular remodeling
Organoid
Chorioallantoic membrane
Mouse embryonic stem cells
Language English
License 2025. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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Snippet The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling mechanisms are...
Abstract The dynamic remodeling of the nascent vascular network into a mature hierarchy is essential for embryo survival. Cell behaviors and signaling...
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pubmedcentral
proquest
pubmed
crossref
springer
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Open Access Repository
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Index Database
Publisher
StartPage 7150
SubjectTerms 631/136/16
631/1647/767/1657
Animal models
Animals
Blood flow
Blood Vessels
Cell survival
Chick Embryo
Chorioallantoic membrane
Chorioallantoic Membrane - blood supply
Embryos
Humanities and Social Sciences
Mice
Morphogenesis
Mouse embryonic stem cells
multidisciplinary
Muscle, Smooth, Vascular - cytology
Myocytes, Smooth Muscle - cytology
Myocytes, Smooth Muscle - metabolism
Neovascularization, Physiologic
Organoid
Organoids
Organoids - cytology
Organoids - transplantation
Pericytes
Pericytes - cytology
Pericytes - metabolism
Progenitor cells
Science
Science (multidisciplinary)
Smooth muscle
Transplantation
Vascular remodeling
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Title In vivo transplantation of mammalian vascular organoids onto the chick chorioallantoic membrane reveals the formation of a hierarchical vascular network
URI https://link.springer.com/article/10.1038/s41598-025-91826-y
https://www.ncbi.nlm.nih.gov/pubmed/40021912
https://www.proquest.com/docview/3172396310
https://www.proquest.com/docview/3172777956
https://pubmed.ncbi.nlm.nih.gov/PMC11871353
https://doaj.org/article/afb107b26f894be0b1877992ff32f630
Volume 15
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