Heritability of carotid intima-media thickness and inflammatory factors of atherosclerosis in a Chinese population
Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity C-reactive protein (CRP) and fibrinogen have been demonstrated to be associated with atherosclerosis. Previous studies on heritability estimates of I...
Saved in:
| Published in | Scientific reports Vol. 14; no. 1; pp. 20440 - 10 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
03.09.2024
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity C-reactive protein (CRP) and fibrinogen have been demonstrated to be associated with atherosclerosis. Previous studies on heritability estimates of IMT, CRP, and fibrinogen among Chinese populations are limited. This study aims to estimate the heritability of these risk factors in residents who participated in the Taichung Community Health Study (TCHS) and their family members. A total of 2671 study subjects from 805 families were enrolled in the study, selected from a random sample of TCHS participants and their family members. CRP, and fibrinogen were obtained from each participant, and a questionnaire interview was conducted. cIMT was measured by high-resolution B-mode ultrasound and expressed as the mean of the maximum. Heritability estimates and the familial correlation of cIMT, CRP, and fibrinogen among family pairs were determined with SAGE software. With multivariate adjustments, significant heritability was found for cIMT (h
2
= 0.26,
P
< 0.001), CRP (h
2
= 0.34,
P
< 0.001), and fibrinogen (h
2
= 0.48,
P
< 0.001). The intrafamilial correlation coefficients for the three indexes in the parent–offspring pairs were significant (
P
< 0.001) and ranged from 0.17 to 0.41. The full sibship correlations were also significant (
P
< 0.001) for the three indexes and ranged from 0.19 to 0.47. This study indicates that a moderate proportion of the variability in CRP, fibrinogen, and cIMT can be attributed to genetic factors in Chinese populations. The findings suggest that CRP is associated with cIMT, whereas no significant association exists between fibrinogen and cIMT. |
|---|---|
| AbstractList | Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity C-reactive protein (CRP) and fibrinogen have been demonstrated to be associated with atherosclerosis. Previous studies on heritability estimates of IMT, CRP, and fibrinogen among Chinese populations are limited. This study aims to estimate the heritability of these risk factors in residents who participated in the Taichung Community Health Study (TCHS) and their family members. A total of 2671 study subjects from 805 families were enrolled in the study, selected from a random sample of TCHS participants and their family members. CRP, and fibrinogen were obtained from each participant, and a questionnaire interview was conducted. cIMT was measured by high-resolution B-mode ultrasound and expressed as the mean of the maximum. Heritability estimates and the familial correlation of cIMT, CRP, and fibrinogen among family pairs were determined with SAGE software. With multivariate adjustments, significant heritability was found for cIMT (h2 = 0.26, P < 0.001), CRP (h2 = 0.34, P < 0.001), and fibrinogen (h2 = 0.48, P < 0.001). The intrafamilial correlation coefficients for the three indexes in the parent-offspring pairs were significant (P < 0.001) and ranged from 0.17 to 0.41. The full sibship correlations were also significant (P < 0.001) for the three indexes and ranged from 0.19 to 0.47. This study indicates that a moderate proportion of the variability in CRP, fibrinogen, and cIMT can be attributed to genetic factors in Chinese populations. The findings suggest that CRP is associated with cIMT, whereas no significant association exists between fibrinogen and cIMT.Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity C-reactive protein (CRP) and fibrinogen have been demonstrated to be associated with atherosclerosis. Previous studies on heritability estimates of IMT, CRP, and fibrinogen among Chinese populations are limited. This study aims to estimate the heritability of these risk factors in residents who participated in the Taichung Community Health Study (TCHS) and their family members. A total of 2671 study subjects from 805 families were enrolled in the study, selected from a random sample of TCHS participants and their family members. CRP, and fibrinogen were obtained from each participant, and a questionnaire interview was conducted. cIMT was measured by high-resolution B-mode ultrasound and expressed as the mean of the maximum. Heritability estimates and the familial correlation of cIMT, CRP, and fibrinogen among family pairs were determined with SAGE software. With multivariate adjustments, significant heritability was found for cIMT (h2 = 0.26, P < 0.001), CRP (h2 = 0.34, P < 0.001), and fibrinogen (h2 = 0.48, P < 0.001). The intrafamilial correlation coefficients for the three indexes in the parent-offspring pairs were significant (P < 0.001) and ranged from 0.17 to 0.41. The full sibship correlations were also significant (P < 0.001) for the three indexes and ranged from 0.19 to 0.47. This study indicates that a moderate proportion of the variability in CRP, fibrinogen, and cIMT can be attributed to genetic factors in Chinese populations. The findings suggest that CRP is associated with cIMT, whereas no significant association exists between fibrinogen and cIMT. Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity C-reactive protein (CRP) and fibrinogen have been demonstrated to be associated with atherosclerosis. Previous studies on heritability estimates of IMT, CRP, and fibrinogen among Chinese populations are limited. This study aims to estimate the heritability of these risk factors in residents who participated in the Taichung Community Health Study (TCHS) and their family members. A total of 2671 study subjects from 805 families were enrolled in the study, selected from a random sample of TCHS participants and their family members. CRP, and fibrinogen were obtained from each participant, and a questionnaire interview was conducted. cIMT was measured by high-resolution B-mode ultrasound and expressed as the mean of the maximum. Heritability estimates and the familial correlation of cIMT, CRP, and fibrinogen among family pairs were determined with SAGE software. With multivariate adjustments, significant heritability was found for cIMT (h 2 = 0.26, P < 0.001), CRP (h 2 = 0.34, P < 0.001), and fibrinogen (h 2 = 0.48, P < 0.001). The intrafamilial correlation coefficients for the three indexes in the parent–offspring pairs were significant ( P < 0.001) and ranged from 0.17 to 0.41. The full sibship correlations were also significant ( P < 0.001) for the three indexes and ranged from 0.19 to 0.47. This study indicates that a moderate proportion of the variability in CRP, fibrinogen, and cIMT can be attributed to genetic factors in Chinese populations. The findings suggest that CRP is associated with cIMT, whereas no significant association exists between fibrinogen and cIMT. Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity C-reactive protein (CRP) and fibrinogen have been demonstrated to be associated with atherosclerosis. Previous studies on heritability estimates of IMT, CRP, and fibrinogen among Chinese populations are limited. This study aims to estimate the heritability of these risk factors in residents who participated in the Taichung Community Health Study (TCHS) and their family members. A total of 2671 study subjects from 805 families were enrolled in the study, selected from a random sample of TCHS participants and their family members. CRP, and fibrinogen were obtained from each participant, and a questionnaire interview was conducted. cIMT was measured by high-resolution B-mode ultrasound and expressed as the mean of the maximum. Heritability estimates and the familial correlation of cIMT, CRP, and fibrinogen among family pairs were determined with SAGE software. With multivariate adjustments, significant heritability was found for cIMT (h2 = 0.26, P < 0.001), CRP (h2 = 0.34, P < 0.001), and fibrinogen (h2 = 0.48, P < 0.001). The intrafamilial correlation coefficients for the three indexes in the parent–offspring pairs were significant (P < 0.001) and ranged from 0.17 to 0.41. The full sibship correlations were also significant (P < 0.001) for the three indexes and ranged from 0.19 to 0.47. This study indicates that a moderate proportion of the variability in CRP, fibrinogen, and cIMT can be attributed to genetic factors in Chinese populations. The findings suggest that CRP is associated with cIMT, whereas no significant association exists between fibrinogen and cIMT. Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity C-reactive protein (CRP) and fibrinogen have been demonstrated to be associated with atherosclerosis. Previous studies on heritability estimates of IMT, CRP, and fibrinogen among Chinese populations are limited. This study aims to estimate the heritability of these risk factors in residents who participated in the Taichung Community Health Study (TCHS) and their family members. A total of 2671 study subjects from 805 families were enrolled in the study, selected from a random sample of TCHS participants and their family members. CRP, and fibrinogen were obtained from each participant, and a questionnaire interview was conducted. cIMT was measured by high-resolution B-mode ultrasound and expressed as the mean of the maximum. Heritability estimates and the familial correlation of cIMT, CRP, and fibrinogen among family pairs were determined with SAGE software. With multivariate adjustments, significant heritability was found for cIMT (h = 0.26, P < 0.001), CRP (h = 0.34, P < 0.001), and fibrinogen (h = 0.48, P < 0.001). The intrafamilial correlation coefficients for the three indexes in the parent-offspring pairs were significant (P < 0.001) and ranged from 0.17 to 0.41. The full sibship correlations were also significant (P < 0.001) for the three indexes and ranged from 0.19 to 0.47. This study indicates that a moderate proportion of the variability in CRP, fibrinogen, and cIMT can be attributed to genetic factors in Chinese populations. The findings suggest that CRP is associated with cIMT, whereas no significant association exists between fibrinogen and cIMT. Abstract Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity C-reactive protein (CRP) and fibrinogen have been demonstrated to be associated with atherosclerosis. Previous studies on heritability estimates of IMT, CRP, and fibrinogen among Chinese populations are limited. This study aims to estimate the heritability of these risk factors in residents who participated in the Taichung Community Health Study (TCHS) and their family members. A total of 2671 study subjects from 805 families were enrolled in the study, selected from a random sample of TCHS participants and their family members. CRP, and fibrinogen were obtained from each participant, and a questionnaire interview was conducted. cIMT was measured by high-resolution B-mode ultrasound and expressed as the mean of the maximum. Heritability estimates and the familial correlation of cIMT, CRP, and fibrinogen among family pairs were determined with SAGE software. With multivariate adjustments, significant heritability was found for cIMT (h2 = 0.26, P < 0.001), CRP (h2 = 0.34, P < 0.001), and fibrinogen (h2 = 0.48, P < 0.001). The intrafamilial correlation coefficients for the three indexes in the parent–offspring pairs were significant (P < 0.001) and ranged from 0.17 to 0.41. The full sibship correlations were also significant (P < 0.001) for the three indexes and ranged from 0.19 to 0.47. This study indicates that a moderate proportion of the variability in CRP, fibrinogen, and cIMT can be attributed to genetic factors in Chinese populations. The findings suggest that CRP is associated with cIMT, whereas no significant association exists between fibrinogen and cIMT. |
| ArticleNumber | 20440 |
| Author | Liu, Chiu-Shong Li, Tsai-Chung Yang, Shing-Yu Li, Chia-Ing Lin, Cheng-Chieh Lin, Chih-Hsueh |
| Author_xml | – sequence: 1 givenname: Tsai-Chung surname: Li fullname: Li, Tsai-Chung organization: Department of Public Health, College of Public Health, China Medical University, Department of Audiology and Speech-Language Pathology, Asia University – sequence: 2 givenname: Cheng-Chieh surname: Lin fullname: Lin, Cheng-Chieh organization: School of Medicine, College of Medicine, China Medical University, Department of Family Medicine, China Medical University Hospital, Department of Medical Research, China Medical University Hospital – sequence: 3 givenname: Chiu-Shong surname: Liu fullname: Liu, Chiu-Shong organization: School of Medicine, College of Medicine, China Medical University, Department of Family Medicine, China Medical University Hospital – sequence: 4 givenname: Chih-Hsueh surname: Lin fullname: Lin, Chih-Hsueh organization: School of Medicine, College of Medicine, China Medical University, Department of Family Medicine, China Medical University Hospital – sequence: 5 givenname: Shing-Yu surname: Yang fullname: Yang, Shing-Yu organization: Department of Public Health, College of Public Health, China Medical University – sequence: 6 givenname: Chia-Ing surname: Li fullname: Li, Chia-Ing email: 006446@tool.caaumed.org.tw organization: School of Medicine, College of Medicine, China Medical University, Department of Medical Research, China Medical University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39227703$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kstu1DAUhiNUREvpC7BAkdiwCfgWX1YIjYBWqsQG1pbjy4yHxB5sp9K8Pc6klJYFXtiW_Z3_XF82ZyEG2zSvIXgPAeYfMoG94B1ApGOQ9KTjz5oLBEjfIYzQ2aP7eXOV8x7U1SNBoHjRnGOBEGMAXzTp2iZf1OBHX45tdK1WKRZvWh-Kn1Q3WeNVW3Ze_ww251aF5cuNappUienYOqXrmRdTVXY2xazHZfe5cq1qNztfDW17iId5VMXH8Kp57tSY7dX9edn8-PL5--a6u_329Wbz6bbTRKDSUSeYGKjhxmIMuesV08qQQRBAKERCQ0cRMZRpigWnA3A9BGahgCDaanzZ3Ky6Jqq9PKSaTjrKqLw8PcS0lSoVX8OVQlGDCOEOsOrcaW4HQw3ABiHHNRqq1sdV6zAPtSTahpLU-ET06U_wO7mNdxJCzKCArCq8u1dI8ddsc5GTz9qOowo2zlliWPtT8-K8om__QfdxTqHW6kRhSghbqDePQ3qI5U9vK4BWQNd25GTdAwKBXGZIrjMk6wzJ0wzJRRWvRrnCYWvTX9__sfoNzCfKuw |
| Cites_doi | 10.1161/01.STR.0000149936.33498.83 10.1161/01.STR.0000155746.65185.4e 10.1016/j.atherosclerosis.2007.12.009 10.1017/S136898001500124X 10.1046/j.1529-8817.2004.00078.x 10.1111/j.1469-1809.2006.00280.x 10.1161/01.ATV.0000015329.15481.E8 10.2337/diacare.29.03.06.dc05-0679 10.1161/01.STR.30.4.841 10.1007/s40520-016-0575-9 10.1161/01.STR.27.5.833 10.1016/j.atherosclerosis.2005.02.015 10.3389/fgene.2023.1132110 10.1161/01.STR.0000019909.71547.AA 10.1016/j.amjcard.2008.05.049 10.1016/j.echo.2007.11.011 10.1016/S0021-9150(00)00586-4 10.1016/j.numecd.2013.10.031 10.1159/000441103 10.1017/thg.2014.19 10.1093/aje/kwn211 10.1159/000083032 10.1161/hq0302.104906 10.1161/STROKEAHA.109.554121 10.1016/j.amjhyper.2006.09.005 10.1136/bmjopen-2021-059910 10.1016/S0008-6363(01)00534-X 10.1161/01.CIR.0000120708.59903.1B 10.1016/j.atherosclerosis.2013.09.005 10.1046/j.1440-1681.2001.03576.x 10.3945/ajcn.115.112151 10.1016/S0140-6736(87)92557-8 10.37796/2211-8039.1174 10.1161/01.STR.0000142132.20442.d8 10.1371/journal.pone.0262395 10.1097/HJH.0b013e328011753e 10.1007/s11745-007-3138-1 10.1016/j.atherosclerosis.2005.11.030 10.1161/01.ATV.0000143856.01669.e7 10.1161/CIRCULATIONAHA.106.628875 10.1161/01.STR.0000182254.47941.96 10.1136/tobaccocontrol-2013-051004 10.1016/j.jstrokecerebrovasdis.2015.06.039 10.1371/journal.pone.0178815 10.1373/clinchem.2003.028258 10.1017/thg.2013.58 10.1161/01.STR.0000185719.66735.dd 10.1038/oby.2008.556 10.1016/j.atherosclerosis.2007.07.030 10.1016/S0140-6736(00)03541-8 10.1038/sj.gene.6364395 10.1161/01.CIR.101.13.1546 10.1289/ehp.10754 10.1016/S0140-6736(14)61682-2 10.1159/000441085 10.1093/eurheartj/ehy165 10.1161/01.CIR.96.5.1432 10.1093/oxfordjournals.aje.a009302 10.1111/j.1538-7836.2005.01778.x 10.1161/JAHA.116.004757 10.1016/S0140-6736(96)07495-8 10.1016/j.atherosclerosis.2015.12.020 10.1016/j.jclinepi.2006.02.015 10.1177/174182670200900205 10.5551/jat.23580 10.2337/diacare.28.8.1882 10.1056/NEJMoa1012592 10.1016/S0140-6736(09)61717-7 10.1038/sj.gene.6364330 10.1016/j.atherosclerosis.2007.09.027 10.1016/S0049-3848(03)00288-3 10.1093/oxfordjournals.aje.a116078 10.1161/01.ATV.18.10.1559 10.1161/01.STR.0000048214.56981.6F 10.1161/01.STR.25.8.1581 10.1177/1741826711422763 10.1186/1471-2458-7-239 10.1161/01.ATV.0000032656.91352.5E 10.1016/S0021-9150(02)00317-9 10.1016/S0021-9150(03)00192-8 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2024 2024. The Author(s). The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Author(s) 2024 2024 |
| Copyright_xml | – notice: The Author(s) 2024 – notice: 2024. The Author(s). – notice: The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: The Author(s) 2024 2024 |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI Q9U 7X8 5PM DOA |
| DOI | 10.1038/s41598-024-71454-8 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni) Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef Publicly Available Content Database MEDLINE |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature Open Access Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 10 |
| ExternalDocumentID | oai_doaj_org_article_9a6d2448f07c49fc8ebd6d03d22f8c2b PMC11371917 39227703 10_1038_s41598_024_71454_8 |
| Genre | Journal Article |
| GeographicLocations | China |
| GeographicLocations_xml | – name: China |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFPKN CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 7XB 8FK AARCD K9. PJZUB PKEHL PPXIY PQEST PQGLB PQUKI Q9U 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c492t-6f979b6d8de3318f5a7cad4b94046129c1f624d67c63986b0f510d5a7c094cec3 |
| IEDL.DBID | 7X7 |
| ISSN | 2045-2322 |
| IngestDate | Wed Aug 27 01:08:21 EDT 2025 Thu Aug 21 18:35:43 EDT 2025 Thu Jul 10 23:21:25 EDT 2025 Wed Aug 13 06:06:10 EDT 2025 Thu Apr 03 07:03:37 EDT 2025 Tue Jul 01 03:22:53 EDT 2025 Fri Feb 21 02:37:59 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | CRP Intima-media thickness Heritability |
| Language | English |
| License | 2024. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c492t-6f979b6d8de3318f5a7cad4b94046129c1f624d67c63986b0f510d5a7c094cec3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://www.proquest.com/docview/3100364478?pq-origsite=%requestingapplication% |
| PMID | 39227703 |
| PQID | 3100364478 |
| PQPubID | 2041939 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_9a6d2448f07c49fc8ebd6d03d22f8c2b pubmedcentral_primary_oai_pubmedcentral_nih_gov_11371917 proquest_miscellaneous_3100561288 proquest_journals_3100364478 pubmed_primary_39227703 crossref_primary_10_1038_s41598_024_71454_8 springer_journals_10_1038_s41598_024_71454_8 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-09-03 |
| PublicationDateYYYYMMDD | 2024-09-03 |
| PublicationDate_xml | – month: 09 year: 2024 text: 2024-09-03 day: 03 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2024 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | SteinJHKorcarzCEHurstRTLonnEKendallCBMohlerERNajjarSSRemboldCMPostWSUse of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: A consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular MedicineJ. Am. Soc. Echocardiogr. Off. Publ. Am. Soc. Echocardiogr.20082129311110.1016/j.echo.2007.11.011quiz 189–190 Sayed-TabatabaeiFAvan RijnMJSchutAFAulchenkoYSCroesEAZillikensMCPolsHAWittemanJCOostraBAvan DuijnCMHeritability of the function and structure of the arterial wall: Findings of the Erasmus Rucphen Family (ERF) studyStroke J. Cereb. Circ.200536112351235610.1161/01.STR.0000185719.66735.dd1:STN:280:DC%2BD2MrnsVCqsA%3D%3D PankowJSFolsomARCushmanMBoreckiIBHopkinsPNEckfeldtJHTracyRPFamilial and genetic determinants of systemic markers of inflammation: The NHLBI family heart studyAtherosclerosis200115436816891125727010.1016/S0021-9150(00)00586-41:CAS:528:DC%2BD3MXitVOmsro%3D BerrahmouneHHerbethBSiestGVisvikis-SiestSHeritability of serum hs-CRP concentration and 5-year changes in the Stanislas family study: Association with apolipoprotein E allelesGenes Immun.2007843523591746072410.1038/sj.gene.63643951:CAS:528:DC%2BD2sXmtFSjsL0%3D CeceljaMJiangBKeehnLHussainTSilva VieiraMPhinikaridouAGreilGSpectorTDChowienczykPArterial stiffening is a heritable trait associated with arterial dilation but not wall thickening: A longitudinal study in the twins UK cohortEur. Heart J.201839242282228829590330601208010.1093/eurheartj/ehy165 PetersenKSCliftonPMBlanchNKeoghJBEffect of improving dietary quality on carotid intima media thickness in subjects with type 1 and type 2 diabetes: A 12-mo randomized controlled trialAm. J. Clin. Nutr.201510247717792635454210.3945/ajcn.115.1121511:CAS:528:DC%2BC28XisFagtrc%3D SaccoRLBlantonSHSliferSBeechamAGloverKGardenerHWangLSabalaEJuoSHRundekTHeritability and linkage analysis for carotid intima-media thickness: The family study of stroke risk and carotid atherosclerosisStroke J. Cereb. Circ.20094072307231210.1161/STROKEAHA.109.5541211:CAS:528:DC%2BD1MXnsFyju78%3D Reding-BernalASanchez-PedrazaVMoreno-MaciasHSobrino-CossioSTejero-BarreraMEBurguete-GarciaAILeon-HernandezMSerratos-CanalesMFDuggiralaRLopez-AlvarengaJCHeritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico CityPloS One2017126e017881528582452545945510.1371/journal.pone.0178815 HamstenAIseliusLde FaireUBlombackMGenetic and cultural inheritance of plasma fibrinogen concentrationLancet198728566988991288995910.1016/S0140-6736(87)92557-81:STN:280:DyaL1c%2FjslOmsA%3D%3D WareLJMaposaIKolkenbeck-RuhANorrisSASoepnelLCrouchSKaguraJNaidooSSmithWDaviesJAre cardiovascular health measures heritable across three generations of families in Soweto, South Africa? A cross-sectional analysis using the random family methodBMJ Open2022129e05991036153021951159110.1136/bmjopen-2021-059910 NorthKEMacCluerJWDevereuxRBHowardBVWeltyTKBestLGLeeETFabsitzRRRomanMJHeritability of carotid artery structure and function: The Strong Heart Family StudyArterioscler. Thromb. Vasc. Biol.20022210169817031237775210.1161/01.ATV.0000032656.91352.5E1:CAS:528:DC%2BD38XnsVKrt74%3D Emerging Risk Factors CollaborationKaptogeSDi AngelantonioELoweGPepysMBThompsonSGCollinsRDaneshJC-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysisLancet2010375970913214010.1016/S0140-6736(09)61717-7 FreemanMSMansfieldMWBarrettJHGrantPJGenetic contribution to circulating levels of hemostatic factors in healthy families with effects of known genetic polymorphisms on heritabilityArterioscler. Thromb. Vasc. Biol.20022235065101188429810.1161/hq0302.1049061:CAS:528:DC%2BD38XitFGgt7s%3D FriedlanderYKarkJDSinnreichRTracyRPSiscovickDSFibrinogen and CRP in Israeli families: Genetic and environmental sources of concentrations and longitudinal changesAtherosclerosis200618911691771638674410.1016/j.atherosclerosis.2005.11.0301:CAS:528:DC%2BD28XhtVajsr3I ChenYCGuoXRaffelLJXiangAHFangBHsuehWATaylorKDBuchananTAHodisHNRotterJICarotid intima-media thickness (cIMT) cosegregates with blood pressure and renal function in hypertensive Hispanic familiesAtherosclerosis200819811601651802893310.1016/j.atherosclerosis.2007.09.0271:CAS:528:DC%2BD1cXktFCmu7Y%3D RyabikovAMalyutinaSRyabikovMKuznetsovaTStaessenJANikitinYIntrafamilial correlations of carotid intima-media thickness and flow-mediated dilation in a Siberian populationAm. J. Hypertens.20072032482541732473410.1016/j.amjhyper.2006.09.005 FroyshovHMBjorneremAEngstadTHalvorsenDSElevated inflammatory markers predict mortality in long-term ischemic stroke-survivors: A population-based prospective studyAging Clin. Exp. Res.20172933793852714666610.1007/s40520-016-0575-9 KuipersALKammererCMMiljkovicIWoodardGABunkerCHPatrickALWheelerVWNewmanABZmudaJMGenetic epidemiology and genome-wide linkage analysis of carotid artery ultrasound traits in multigenerational African ancestry familiesAtherosclerosis201323111201232412542110.1016/j.atherosclerosis.2013.09.0051:CAS:528:DC%2BC3sXhs1Whtr3N SasAARijsdijkFVOrmelJSniederHRieseHThe relationship between neuroticism and inflammatory markers: A twin studyTwin Res. Hum. Genet.20141731771822473571910.1017/thg.2014.19 Barker-ColloSBennettDAKrishnamurthiRParmarPFeiginVNaghaviMForouzanfarMJohnsonCNguyenGMensahGSex Differences in stroke incidence, prevalence, mortality and disability-adjusted life years: Results from the global burden of disease study 2013Neuroepidemiology20154532032142650598410.1159/000441103 SaundersCLGullifordMCHeritabilities and shared environmental effects were estimated from household clustering in national health survey dataJ. Clin. Epidemiol.20065911119111981702743010.1016/j.jclinepi.2006.02.015 TangWHongYProvinceMARichSSHopkinsPNArnettDKPankowJSMillerMBEckfeldtJHFamilial clustering for features of the metabolic syndrome: The National Heart, Lung, and Blood Institute (NHLBI) Family Heart StudyDiabetes Care20062936316361650551810.2337/diacare.29.03.06.dc05-0679 EbrahimSPapacostaOWhincupPWannametheeGWalkerMNicolaidesANDhanjilSGriffinMBelcaroGRumleyACarotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: The British Regional Heart StudyStroke19993048418501018788910.1161/01.STR.30.4.8411:STN:280:DyaK1M3gsFensA%3D%3D LinCCLiuCSLaiMMLiCIChenCCChangPCLinWYLeeYDLinTLiTCMetabolic syndrome in a Taiwanese metropolitan adult populationBMC Public Health2007723917850675204895110.1186/1471-2458-7-239 McClintockTRParvezFWuFIslamTAhmedARani PaulRShaheenISarwarGRundekTDemmerRTMajor dietary patterns and carotid intima-media thickness in BangladeshPublic Health Nutr.20161922182292595886010.1017/S136898001500124X MoskauSGollaAGrotheCBoesMPohlCKlockgetherTHeritability of carotid artery atherosclerotic lesions: An ultrasound study in 154 familiesStroke J. Cereb. Circ.20053615810.1161/01.STR.0000149936.33498.83 BladbjergEMde MaatMPChristensenKBathumLJespersenJHjelmborgJGenetic influence on thrombotic risk markers in the elderly—A Danish twin studyJ. Thromb. Haemost. JTH2006435996071637111710.1111/j.1538-7836.2005.01778.x1:STN:280:DC%2BD28%2Fns1eksg%3D%3D These Are the Top 10 Causes of Death in the U.S. https://www.webmd.com/a-to-z-guides/news/20231006/these-are-the-top-10-causes-of-death-in-the-us. WilliamsPTQuantile-specific heritability of plasma fibrinogen concentrationsPloS One2022171e026239534995330874104910.1371/journal.pone.02623951:CAS:528:DC%2BB38XhtVGrtb0%3D LeeKSungJLeeSCParkSWKimYSLeeJYEbrahimSSongYMSegment-specific carotid intima-media thickness and cardiovascular risk factors in Koreans: The Healthy Twin StudyEur. J. Prev. Cardiol.2012195116111722191468510.1177/1741826711422763 SoutoJCAlmasyLBorrellMGariMMartinezEMateoJStoneWHBlangeroJFontcubertaJGenetic determinants of hemostasis phenotypes in Spanish familiesCirculation200010113154615511074734810.1161/01.CIR.101.13.15461:CAS:528:DC%2BD3cXivVyhtr8%3D MacGregorAJGallimoreJRSpectorTDPepysMBGenetic effects on baseline values of C-reactive protein and serum amyloid a protein: A comparison of monozygotic and dizygotic twinsClin. Chem.20045011301341463390710.1373/clinchem.2003.0282581:CAS:528:DC%2BD2cXovFWgtw%3D%3D KaoWHHsuehWCRainwaterDLO'LearyDHImumorinIGSternMPMitchellBDFamily history of type 2 diabetes is associated with increased carotid artery intimal-medial thickness in Mexican AmericansDiabetes Care2005288188218891604372710.2337/diacare.28.8.1882 MayosiBMAveryPJBakerMGaukrodgerNImrieHGreenFRFarrallMWatkinsHKeavneyBGenotype at the -174G/C polymorphism of the interleukin-6 gene is associated with common carotid artery intimal-medial thickness: Family study and meta-analysisStroke J. Cereb. Circ.200536102215221910.1161/01.STR.0000182254.47941.961:CAS:528:DC%2BD2MXhtVeisbbK NagasawaSYOhkuboTMasakiKBarinas-MitchellEMiuraKSetoTEl-SaedAKadowakiTWillcoxBJEdmundowiczDAssociations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP StudyJ. Atheroscler. Thromb.20152265905982544588810.5551/jat.235801:CAS:528:DC%2BC2MXhsVGiu73I AustinMAZhangCHumphriesSEChandlerWLTalmudPJEdwardsKLLeonettiDLMcNeelyMJFujimotoWYHeritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese AmericansAnn. Hum. Genet.200468Pt 31791881518069810.1046/j.1529-8817.2004.00078.x1:CAS:528:DC%2BD2cXlvF2hurs%3D XiangAHAzenSPBuchananTARaffelLJTanSChengLSDiazJToscanoEQuinonnesMLiuCRHeritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parentArterioscler. Thromb. Vasc. Biol.20022258438481200640010.1161/01.ATV.0000015329.15481.E81:CAS:528:DC%2BD38XjslGmurg%3D RyderJRPankratzNDDengelDRPankowJSJacobsDRJrSinaikoARGootyVSteinbergerJHeritability of Vascular Structure and Function: A Parent-Child StudyJ. Am. Heart Assoc.20176228154165552377110.1161/JAHA.116.004757 H Li (71454_CR69) 2013; 23 M Cecelja (71454_CR78) 2018; 39 K Kawase Ishihara (71454_CR80) 2015; 24 YW Tsai (71454_CR83) 2015; 24 JR Ryder (71454_CR71) 2017; 6 A Reding-Bernal (71454_CR34) 2017; 12 TR McClintock (71454_CR84) 2016; 19 Y Friedlander (71454_CR26) 2006; 189 RL Sacco (71454_CR68) 2009; 40 71454_CR1 KS Petersen (71454_CR85) 2015; 102 CL Saunders (71454_CR28) 2006; 59 PT Williams (71454_CR50) 2022; 17 S Moskau (71454_CR38) 2005; 36 LA Lange (71454_CR56) 2002; 33 CS Fox (71454_CR58) 2003; 34 A Hamsten (71454_CR43) 1987; 2 KL Chien (71454_CR65) 2008; 43 SH Juo (71454_CR59) 2004; 35 71454_CR7 HM Froyshov (71454_CR19) 2017; 29 71454_CR6 JF Polak (71454_CR13) 2011; 365 L Swan (71454_CR74) 2003; 166 LE Chambless (71454_CR9) 1997; 146 M Neijts (71454_CR33) 2013; 16 E Medda (71454_CR77) 2014; 24 M Ghowsi (71454_CR20) 2021; 11 S Su (71454_CR41) 2008; 200 E Rampersaud (71454_CR67) 2008; 168 J Wessel (71454_CR40) 2007; 25 JC Souto (71454_CR46) 2000; 101 JH Stein (71454_CR16) 2008; 21 LG Best (71454_CR24) 2004; 58 CJ Murray (71454_CR5) 1997; 349 H Berrahmoune (71454_CR30) 2007; 8 A Ryabikov (71454_CR64) 2007; 20 Y Friedlander (71454_CR44) 1995; 56 G Heiss (71454_CR15) 1991; 134 J Dupuis (71454_CR25) 2005; 182 WH Kao (71454_CR63) 2005; 28 ER Fox (71454_CR31) 2008; 102 L Retterstol (71454_CR35) 2003; 169 MA Vickers (71454_CR22) 2002; 53 EM Bladbjerg (71454_CR52) 2006; 4 F Zannad (71454_CR54) 2001; 28 M de Lange (71454_CR51) 2001; 357 VL Feigin (71454_CR4) 2015; 45 FA Sayed-Tabatabaei (71454_CR62) 2005; 36 MP de Maat (71454_CR36) 2004; 24 LA Lange (71454_CR29) 2006; 70 J Zhao (71454_CR75) 2008; 197 AL Kuipers (71454_CR70) 2013; 231 W Tang (71454_CR27) 2006; 29 KE North (71454_CR57) 2002; 22 G Howard (71454_CR11) 1994; 25 S Barker-Collo (71454_CR3) 2015; 45 LJ Ware (71454_CR72) 2022; 12 SK Kunutsor (71454_CR18) 2016; 245 MA Austin (71454_CR23) 2004; 68 J Wu (71454_CR32) 2009; 17 JS Pankow (71454_CR21) 2001; 154 YC Chen (71454_CR66) 2008; 198 MW Lorenz (71454_CR12) 2007; 115 SY Nagasawa (71454_CR81) 2015; 22 M Naghavi (71454_CR2) 2015; 385 AA Sas (71454_CR42) 2014; 17 AJ MacGregor (71454_CR37) 2004; 50 Q Yang (71454_CR48) 2003; 110 R Duggirala (71454_CR53) 1996; 27 S Ebrahim (71454_CR10) 1999; 30 K Lee (71454_CR76) 2012; 19 MS Freeman (71454_CR47) 2002; 22 AH Xiang (71454_CR55) 2002; 22 JS Pankow (71454_CR45) 1998; 18 BM Mayosi (71454_CR61) 2005; 36 IM van der Meer (71454_CR14) 2004; 109 MA Worns (71454_CR39) 2006; 7 M Sitzer (71454_CR82) 2002; 9 D Wang (71454_CR60) 2005; 36 CC Lin (71454_CR79) 2007; 7 VP Diego (71454_CR73) 2023; 14 ML Bots (71454_CR8) 1997; 96 U Nowak-Gottl (71454_CR49) 2008; 116 S Kaptoge (71454_CR17) 2010; 375 |
| References_xml | – reference: BotsMLHoesAWKoudstaalPJHofmanAGrobbeeDECommon carotid intima-media thickness and risk of stroke and myocardial infarction: The Rotterdam StudyCirculation199796514321437931552810.1161/01.CIR.96.5.14321:STN:280:DyaK2svlvFGlug%3D%3D – reference: TangWHongYProvinceMARichSSHopkinsPNArnettDKPankowJSMillerMBEckfeldtJHFamilial clustering for features of the metabolic syndrome: The National Heart, Lung, and Blood Institute (NHLBI) Family Heart StudyDiabetes Care20062936316361650551810.2337/diacare.29.03.06.dc05-0679 – reference: LangeLABurdonKLangefeldCDLiuYBeckSRRichSSFreedmanBIBrosnihanKBHerringtonDMWagenknechtLEHeritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart StudyAnn. Hum. Genet.200670Pt 67177251704484610.1111/j.1469-1809.2006.00280.x1:CAS:528:DC%2BD28Xht1KltrvF – reference: CeceljaMJiangBKeehnLHussainTSilva VieiraMPhinikaridouAGreilGSpectorTDChowienczykPArterial stiffening is a heritable trait associated with arterial dilation but not wall thickening: A longitudinal study in the twins UK cohortEur. Heart J.201839242282228829590330601208010.1093/eurheartj/ehy165 – reference: BestLGNorthKETracyRPLeeETHowardBVPalmieriVMaccluerJWGenetic determination of acute phase reactant levels: The strong heart studyHum. Hered.20045821121161571109110.1159/0000830321:CAS:528:DC%2BD2MXht1ymsLs%3D – reference: MayosiBMAveryPJBakerMGaukrodgerNImrieHGreenFRFarrallMWatkinsHKeavneyBGenotype at the -174G/C polymorphism of the interleukin-6 gene is associated with common carotid artery intimal-medial thickness: Family study and meta-analysisStroke J. Cereb. Circ.200536102215221910.1161/01.STR.0000182254.47941.961:CAS:528:DC%2BD2MXhtVeisbbK – reference: XiangAHAzenSPBuchananTARaffelLJTanSChengLSDiazJToscanoEQuinonnesMLiuCRHeritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parentArterioscler. Thromb. Vasc. Biol.20022258438481200640010.1161/01.ATV.0000015329.15481.E81:CAS:528:DC%2BD38XjslGmurg%3D – reference: RyderJRPankratzNDDengelDRPankowJSJacobsDRJrSinaikoARGootyVSteinbergerJHeritability of Vascular Structure and Function: A Parent-Child StudyJ. Am. Heart Assoc.20176228154165552377110.1161/JAHA.116.004757 – reference: Kawase IshiharaKKokuboYYokotaCHidaEMiyataTToyodaKMatsumotoMMinematsuKMiyamotoYEffect of plasma fibrinogen, high-sensitive c-reactive protein, and cigarette smoking on carotid atherosclerosis: The Suita StudyJ. Stroke Cerebrovas. Dis. Off. J. Natl. Stroke Assoc.201524102385238910.1016/j.jstrokecerebrovasdis.2015.06.039 – reference: FoxCSPolakJFChazaroICupplesAWolfPAD'AgostinoRAO'DonnellCJFramingham HeartSGenetic and environmental contributions to atherosclerosis phenotypes in men and women: Heritability of carotid intima-media thickness in the Framingham Heart StudyStroke J. Cereb. Circ.200334239740110.1161/01.STR.0000048214.56981.6F – reference: FriedlanderYKarkJDSinnreichRTracyRPSiscovickDSFibrinogen and CRP in Israeli families: Genetic and environmental sources of concentrations and longitudinal changesAtherosclerosis200618911691771638674410.1016/j.atherosclerosis.2005.11.0301:CAS:528:DC%2BD28XhtVajsr3I – reference: JuoSHLinHFRundekTSabalaEABoden-AlbalaBParkNLanMYSaccoRLGenetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family StudyStroke J. Cereb. Circ.200435102243224710.1161/01.STR.0000142132.20442.d8 – reference: McClintockTRParvezFWuFIslamTAhmedARani PaulRShaheenISarwarGRundekTDemmerRTMajor dietary patterns and carotid intima-media thickness in BangladeshPublic Health Nutr.20161922182292595886010.1017/S136898001500124X – reference: WilliamsPTQuantile-specific heritability of plasma fibrinogen concentrationsPloS One2022171e026239534995330874104910.1371/journal.pone.02623951:CAS:528:DC%2BB38XhtVGrtb0%3D – reference: HamstenAIseliusLde FaireUBlombackMGenetic and cultural inheritance of plasma fibrinogen concentrationLancet198728566988991288995910.1016/S0140-6736(87)92557-81:STN:280:DyaL1c%2FjslOmsA%3D%3D – reference: WareLJMaposaIKolkenbeck-RuhANorrisSASoepnelLCrouchSKaguraJNaidooSSmithWDaviesJAre cardiovascular health measures heritable across three generations of families in Soweto, South Africa? A cross-sectional analysis using the random family methodBMJ Open2022129e05991036153021951159110.1136/bmjopen-2021-059910 – reference: de MaatMPBladbjergEMHjelmborgJBathumLJespersenJChristensenKGenetic influence on inflammation variables in the elderlyArterioscler. Thromb. Vasc. Biol.20042411216821731534550610.1161/01.ATV.0000143856.01669.e7 – reference: BladbjergEMde MaatMPChristensenKBathumLJespersenJHjelmborgJGenetic influence on thrombotic risk markers in the elderly—A Danish twin studyJ. Thromb. Haemost. JTH2006435996071637111710.1111/j.1538-7836.2005.01778.x1:STN:280:DC%2BD28%2Fns1eksg%3D%3D – reference: FeiginVLKrishnamurthiRVParmarPNorrvingBMensahGABennettDABarker-ColloSMoranAESaccoRLTruelsenTUpdate on the global burden of ischemic and hemorrhagic stroke in 1990–2013: The GBD 2013 studyNeuroepidemiology20154531611762650598110.1159/000441085 – reference: TsaiYWChangLCSungHYHuTWChiouSTThe impact of smoke-free legislation on reducing exposure to secondhand smoke: Differences across gender and socioeconomic groupsTob. Control201524162692401463610.1136/tobaccocontrol-2013-051004 – reference: KuipersALKammererCMMiljkovicIWoodardGABunkerCHPatrickALWheelerVWNewmanABZmudaJMGenetic epidemiology and genome-wide linkage analysis of carotid artery ultrasound traits in multigenerational African ancestry familiesAtherosclerosis201323111201232412542110.1016/j.atherosclerosis.2013.09.0051:CAS:528:DC%2BC3sXhs1Whtr3N – reference: EbrahimSPapacostaOWhincupPWannametheeGWalkerMNicolaidesANDhanjilSGriffinMBelcaroGRumleyACarotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: The British Regional Heart StudyStroke19993048418501018788910.1161/01.STR.30.4.8411:STN:280:DyaK1M3gsFensA%3D%3D – reference: YangQToflerGHCupplesLALarsonMGFengDLindpaintnerKLevyDD'AgostinoRBO'DonnellCJA genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart StudyThromb. Res.2003110157641287791010.1016/S0049-3848(03)00288-31:CAS:528:DC%2BD3sXls1ers7g%3D – reference: Cardiovascular diseases. https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1. – reference: LinCCLiuCSLaiMMLiCIChenCCChangPCLinWYLeeYDLinTLiTCMetabolic syndrome in a Taiwanese metropolitan adult populationBMC Public Health2007723917850675204895110.1186/1471-2458-7-239 – reference: ChamblessLEHeissGFolsomARRosamondWSzkloMSharrettARCleggLXAssociation of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: The Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993Am. J. Epidemiol.19971466483494929050910.1093/oxfordjournals.aje.a0093021:STN:280:DyaK2svjsFynsA%3D%3D – reference: FoxERBenjaminEJSarpongDFRotimiCNWilsonJGSteffesMWChenGAdeyemoATaylorJKSamdarshiTEEpidemiology, heritability, and genetic linkage of C-reactive protein in African Americans (from the Jackson Heart Study)Am. J. Cardiol.2008102783584118805107373344210.1016/j.amjcard.2008.05.0491:CAS:528:DC%2BD1cXhtFektrjJ – reference: ZhaoJCheemaFABremnerJDGoldbergJSuSSniederHMaisanoCJonesLJavedFMurrahNHeritability of carotid intima-media thickness: A twin studyAtherosclerosis200819728148201782530610.1016/j.atherosclerosis.2007.07.0301:CAS:528:DC%2BD1cXktFCkt7s%3D – reference: LorenzMWMarkusHSBotsMLRosvallMSitzerMPrediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and meta-analysisCirculation200711544594671724228410.1161/CIRCULATIONAHA.106.628875 – reference: GhowsiMQalekhaniFFarzaeiMHMahmudiiFYousofvandNJoshiTInflammation, oxidative stress, insulin resistance, and hypertension as mediators for adverse effects of obesity on the brain: A reviewBiomedicine (Taipei)202111413223522341510.37796/2211-8039.1174 – reference: SaundersCLGullifordMCHeritabilities and shared environmental effects were estimated from household clustering in national health survey dataJ. Clin. Epidemiol.20065911119111981702743010.1016/j.jclinepi.2006.02.015 – reference: SwanLBirnieDHInglisGConnellJMHillisWSThe determination of carotid intima medial thickness in adults—A population-based twin studyAtherosclerosis200316611371411248256010.1016/S0021-9150(02)00317-91:CAS:528:DC%2BD38XptlGjsrY%3D – reference: Reding-BernalASanchez-PedrazaVMoreno-MaciasHSobrino-CossioSTejero-BarreraMEBurguete-GarciaAILeon-HernandezMSerratos-CanalesMFDuggiralaRLopez-AlvarengaJCHeritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico CityPloS One2017126e017881528582452545945510.1371/journal.pone.0178815 – reference: MeddaEFagnaniCSchillaciGTarnokiADTarnokiDLBaracchiniCMeneghettiGFanelliFAlaeddinAPucciGHeritability of arterial stiffness and carotid intima-media thickness: An Italian twin studyNutr. Metabol. Cardiovasc. Dis. NMCD201424551151710.1016/j.numecd.2013.10.0311:STN:280:DC%2BC2cvptFagsQ%3D%3D – reference: BerrahmouneHHerbethBSiestGVisvikis-SiestSHeritability of serum hs-CRP concentration and 5-year changes in the Stanislas family study: Association with apolipoprotein E allelesGenes Immun.2007843523591746072410.1038/sj.gene.63643951:CAS:528:DC%2BD2sXmtFSjsL0%3D – reference: Emerging Risk Factors CollaborationKaptogeSDi AngelantonioELoweGPepysMBThompsonSGCollinsRDaneshJC-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysisLancet2010375970913214010.1016/S0140-6736(09)61717-7 – reference: MacGregorAJGallimoreJRSpectorTDPepysMBGenetic effects on baseline values of C-reactive protein and serum amyloid a protein: A comparison of monozygotic and dizygotic twinsClin. Chem.20045011301341463390710.1373/clinchem.2003.0282581:CAS:528:DC%2BD2cXovFWgtw%3D%3D – reference: van der MeerIMBotsMLHofmanAdel SolAIvan der KuipDAWittemanJCPredictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: The Rotterdam StudyCirculation20041099108910941499313010.1161/01.CIR.0000120708.59903.1B – reference: NorthKEMacCluerJWDevereuxRBHowardBVWeltyTKBestLGLeeETFabsitzRRRomanMJHeritability of carotid artery structure and function: The Strong Heart Family StudyArterioscler. Thromb. Vasc. Biol.20022210169817031237775210.1161/01.ATV.0000032656.91352.5E1:CAS:528:DC%2BD38XnsVKrt74%3D – reference: WornsMAVictorAGallePRHohlerTGenetic and environmental contributions to plasma C-reactive protein and interleukin-6 levels—A study in twinsGenes Immun.2006776006051690020310.1038/sj.gene.63643301:STN:280:DC%2BD28nivFSqtw%3D%3D – reference: ChenYCGuoXRaffelLJXiangAHFangBHsuehWATaylorKDBuchananTAHodisHNRotterJICarotid intima-media thickness (cIMT) cosegregates with blood pressure and renal function in hypertensive Hispanic familiesAtherosclerosis200819811601651802893310.1016/j.atherosclerosis.2007.09.0271:CAS:528:DC%2BD1cXktFCmu7Y%3D – reference: FriedlanderYElkanaYSinnreichRKarkJDGenetic and environmental sources of fibrinogen variability in Israeli families: The Kibbutzim Family StudyAm. J. Hum. Genet.199556511941206772617718014531:STN:280:DyaK2M3ktlagug%3D%3D – reference: DuggiralaRGonzalez VillalpandoCO’LearyDHSternMPBlangeroJGenetic basis of variation in carotid artery wall thicknessStroke J. Cereb. Circ.199627583383710.1161/01.STR.27.5.8331:STN:280:DyaK283hsVSjsQ%3D%3D – reference: LiHKuipersAKammererCMBunkerCHKullerLHMiljkovicIPatrickALWheelerVWZmudaJMThe association between renal function biomarkers and subclinical cardiovascular measures in African Caribbean familiesEthn. Dis.201323449249824392614 – reference: SoutoJCAlmasyLBorrellMGariMMartinezEMateoJStoneWHBlangeroJFontcubertaJGenetic determinants of hemostasis phenotypes in Spanish familiesCirculation200010113154615511074734810.1161/01.CIR.101.13.15461:CAS:528:DC%2BD3cXivVyhtr8%3D – reference: RyabikovAMalyutinaSRyabikovMKuznetsovaTStaessenJANikitinYIntrafamilial correlations of carotid intima-media thickness and flow-mediated dilation in a Siberian populationAm. J. Hypertens.20072032482541732473410.1016/j.amjhyper.2006.09.005 – reference: Barker-ColloSBennettDAKrishnamurthiRParmarPFeiginVNaghaviMForouzanfarMJohnsonCNguyenGMensahGSex Differences in stroke incidence, prevalence, mortality and disability-adjusted life years: Results from the global burden of disease study 2013Neuroepidemiology20154532032142650598410.1159/000441103 – reference: de LangeMSniederHAriensRASpectorTDGrantPJThe genetics of haemostasis: A twin studyLancet200135792501011051119739610.1016/S0140-6736(00)03541-8 – reference: WesselJMoratorioGRaoFMahataMZhangLGreeneWRanaBKKennedyBPKhandrikaSHuangPC-reactive protein, an ‘intermediate phenotype’ for inflammation: Human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway lociJ. Hypertens.20072523293431721124010.1097/HJH.0b013e328011753e1:CAS:528:DC%2BD2sXisV2msA%3D%3D – reference: ChienKLLiauCSChenMFLeeYTJengJSHwangBSSuTCPrimary hypercholesterolemia, carotid atherosclerosis and insulin resistance among ChineseLipids20084321171241808478610.1007/s11745-007-3138-11:CAS:528:DC%2BD1cXjvVamsL0%3D – reference: SaccoRLBlantonSHSliferSBeechamAGloverKGardenerHWangLSabalaEJuoSHRundekTHeritability and linkage analysis for carotid intima-media thickness: The family study of stroke risk and carotid atherosclerosisStroke J. Cereb. Circ.20094072307231210.1161/STROKEAHA.109.5541211:CAS:528:DC%2BD1MXnsFyju78%3D – reference: HowardGBurkeGLEvansGWCrouseJR3rdRileyWArnettDde LacyRHeissGRelations of intimal-medial thickness among sites within the carotid artery as evaluated by B-mode ultrasound. ARIC Investigators. Atherosclerosis Risk in CommunitiesStroke199425815811587804220710.1161/01.STR.25.8.15811:STN:280:DyaK2czhslWkuw%3D%3D – reference: ZannadFSassCVisvikisSEnvironmental and genetic determinants of intima-media thickness of the carotid arteryClin. Exp. Pharmacol. Physiol.20012812100710101190330410.1046/j.1440-1681.2001.03576.x1:CAS:528:DC%2BD38XptVSj – reference: SuSSniederHMillerAHRitchieJBremnerJDGoldbergJDaiJJonesLMurrahNVZhaoJGenetic and environmental influences on systemic markers of inflammation in middle-aged male twinsAtherosclerosis2008200121322018243214259992310.1016/j.atherosclerosis.2007.12.0091:CAS:528:DC%2BD1cXhtVensb%2FJ – reference: LeeKSungJLeeSCParkSWKimYSLeeJYEbrahimSSongYMSegment-specific carotid intima-media thickness and cardiovascular risk factors in Koreans: The Healthy Twin StudyEur. J. Prev. Cardiol.2012195116111722191468510.1177/1741826711422763 – reference: HeissGSharrettARBarnesRChamblessLESzkloMAlzolaCCarotid atherosclerosis measured by B-mode ultrasound in populations: Associations with cardiovascular risk factors in the ARIC studyAm. J. Epidemiol.19911343250256187758410.1093/oxfordjournals.aje.a1160781:STN:280:DyaK3MzksFSjtg%3D%3D – reference: Nowak-GottlULangerCBergsSThedieckSStraterRStollMGenetics of hemostasis: Differential effects of heritability and household components influencing lipid concentrations and clotting factor levels in 282 pediatric stroke familiesEnviron. Health Perspect.2008116683984318560491243024310.1289/ehp.10754 – reference: AustinMAZhangCHumphriesSEChandlerWLTalmudPJEdwardsKLLeonettiDLMcNeelyMJFujimotoWYHeritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese AmericansAnn. Hum. Genet.200468Pt 31791881518069810.1046/j.1529-8817.2004.00078.x1:CAS:528:DC%2BD2cXlvF2hurs%3D – reference: LangeLABowdenDWLangefeldCDWagenknechtLECarrJJRichSSRileyWAFreedmanBIHeritability of carotid artery intima-medial thickness in type 2 diabetesStroke J. Cereb. Circ.20023371876188110.1161/01.STR.0000019909.71547.AA – reference: MurrayCJLopezADGlobal mortality, disability, and the contribution of risk factors: Global Burden of Disease StudyLancet1997349906314361442916431710.1016/S0140-6736(96)07495-81:STN:280:DyaK2szgslWjtg%3D%3D – reference: WangDYangHQuinonesMJBulnes-EnriquezIJimenezXDe La RosaRModilevskyTYuKLiYTaylorKDA genome-wide scan for carotid artery intima-media thickness: The Mexican-American Coronary Artery Disease family studyStroke J. Cereb. Circ.200536354054510.1161/01.STR.0000155746.65185.4e1:CAS:528:DC%2BD2MXhtl2murY%3D – reference: DupuisJLarsonMGVasanRSMassaroJMWilsonPWLipinskaICoreyDVitaJAKeaneyJFJrBenjaminEJGenome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: Evidence for susceptibility loci on 1qAtherosclerosis200518223073141615960310.1016/j.atherosclerosis.2005.02.0151:CAS:528:DC%2BD2MXhtVSmtrvK – reference: RampersaudEBielakLFParsaAShenHPostWRyanKADonnellyPRumbergerJASheedyPF2ndPeyserPAThe association of coronary artery calcification and carotid artery intima-media thickness with distinct, traditional coronary artery disease risk factors in asymptomatic adultsAm. J. Epidemiol.200816891016102318805900272077210.1093/aje/kwn211 – reference: The top 10 causes of death. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. – reference: PankowJSFolsomARCushmanMBoreckiIBHopkinsPNEckfeldtJHTracyRPFamilial and genetic determinants of systemic markers of inflammation: The NHLBI family heart studyAtherosclerosis200115436816891125727010.1016/S0021-9150(00)00586-41:CAS:528:DC%2BD3MXitVOmsro%3D – reference: PetersenKSCliftonPMBlanchNKeoghJBEffect of improving dietary quality on carotid intima media thickness in subjects with type 1 and type 2 diabetes: A 12-mo randomized controlled trialAm. J. Clin. Nutr.201510247717792635454210.3945/ajcn.115.1121511:CAS:528:DC%2BC28XisFagtrc%3D – reference: SitzerMMarkusHSMendallMALiehrRKnorrUSteinmetzHC-reactive protein and carotid intimal medial thickness in a community populationJ. Cardiovasc. Risk200292971031200691710.1177/174182670200900205 – reference: NaghaviMWangHLozanoRDavisALiangXZhouMVollsetSEOzgorenAAAbdallaSAbd-AllahFGlobal, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013Lancet2015385996311717110.1016/S0140-6736(14)61682-2 – reference: KunutsorSKKurlSZaccardiFLaukkanenJABaseline and long-term fibrinogen levels and risk of sudden cardiac death: A new prospective study and meta-analysisAtherosclerosis20162451711802672452710.1016/j.atherosclerosis.2015.12.0201:CAS:528:DC%2BC2MXitVyqtbjE – reference: SteinJHKorcarzCEHurstRTLonnEKendallCBMohlerERNajjarSSRemboldCMPostWSUse of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: A consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular MedicineJ. Am. Soc. Echocardiogr. Off. Publ. Am. Soc. Echocardiogr.20082129311110.1016/j.echo.2007.11.011quiz 189–190 – reference: These Are the Top 10 Causes of Death in the U.S. https://www.webmd.com/a-to-z-guides/news/20231006/these-are-the-top-10-causes-of-death-in-the-us. – reference: NagasawaSYOhkuboTMasakiKBarinas-MitchellEMiuraKSetoTEl-SaedAKadowakiTWillcoxBJEdmundowiczDAssociations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP StudyJ. Atheroscler. Thromb.20152265905982544588810.5551/jat.235801:CAS:528:DC%2BC2MXhsVGiu73I – reference: NeijtsMvan DongenJKluftCBoomsmaDIWillemsenGde GeusEJGenetic architecture of the pro-inflammatory state in an extended twin-family designTwin Res. Hum. Genet.20131659319402395334710.1017/thg.2013.58 – reference: SasAARijsdijkFVOrmelJSniederHRieseHThe relationship between neuroticism and inflammatory markers: A twin studyTwin Res. Hum. Genet.20141731771822473571910.1017/thg.2014.19 – reference: PolakJFPencinaMJPencinaKMO'DonnellCJWolfPAD’AgostinoRBSrCarotid-wall intima-media thickness and cardiovascular eventsN. Engl. J. Med.2011365321322121774709315394910.1056/NEJMoa10125921:CAS:528:DC%2BC3MXptlGqs7g%3D – reference: VickersMAGreenFRTerryCMayosiBMJulierCLathropMRatcliffePJWatkinsHCKeavneyBGenotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive proteinCardiovasc. Res.2002534102910341192291310.1016/S0008-6363(01)00534-X1:CAS:528:DC%2BD38Xitlaqu70%3D – reference: KaoWHHsuehWCRainwaterDLO'LearyDHImumorinIGSternMPMitchellBDFamily history of type 2 diabetes is associated with increased carotid artery intimal-medial thickness in Mexican AmericansDiabetes Care2005288188218891604372710.2337/diacare.28.8.1882 – reference: WuJPankowJSTracyRPNorthKEMyersRHFeitosaMEProvinceMABoreckiIBA QTL on 12q influencing an inflammation marker and obesity in white women: The NHLBI Family Heart StudyObesity (Silver Spring)20091735255311923814110.1038/oby.2008.5561:CAS:528:DC%2BD1MXit1Oiu70%3D – reference: RetterstolLEikvarLBergKA twin study of C-Reactive Protein compared to other risk factors for coronary heart diseaseAtherosclerosis200316922792821292197910.1016/S0021-9150(03)00192-81:CAS:528:DC%2BD3sXmt1Gquro%3D – reference: PankowJSFolsomARProvinceMARaoDCWilliamsRREckfeldtJSellersTASegregation analysis of plasminogen activator inhibitor-1 and fibrinogen levels in the NHLBI family heart studyArterioscler. Thromb. Vasc. Biol.1998181015591567976352710.1161/01.ATV.18.10.15591:STN:280:DyaK1cvjvVOisg%3D%3D – reference: Sayed-TabatabaeiFAvan RijnMJSchutAFAulchenkoYSCroesEAZillikensMCPolsHAWittemanJCOostraBAvan DuijnCMHeritability of the function and structure of the arterial wall: Findings of the Erasmus Rucphen Family (ERF) studyStroke J. Cereb. Circ.200536112351235610.1161/01.STR.0000185719.66735.dd1:STN:280:DC%2BD2MrnsVCqsA%3D%3D – reference: FreemanMSMansfieldMWBarrettJHGrantPJGenetic contribution to circulating levels of hemostatic factors in healthy families with effects of known genetic polymorphisms on heritabilityArterioscler. Thromb. Vasc. Biol.20022235065101188429810.1161/hq0302.1049061:CAS:528:DC%2BD38XitFGgt7s%3D – reference: FroyshovHMBjorneremAEngstadTHalvorsenDSElevated inflammatory markers predict mortality in long-term ischemic stroke-survivors: A population-based prospective studyAging Clin. Exp. Res.20172933793852714666610.1007/s40520-016-0575-9 – reference: DiegoVPManusovEGMaoXCurranJEGoringHAlmeidaMMahaneyMCPeraltaJMBlangeroJWilliams-BlangeroSGenotype-by-socioeconomic status interaction influences heart disease risk scores and carotid artery thickness in Mexican Americans: The predominant role of education in comparison to household income and socioeconomic indexFront Genet2023141132110377952461054714510.3389/fgene.2023.1132110 – reference: MoskauSGollaAGrotheCBoesMPohlCKlockgetherTHeritability of carotid artery atherosclerotic lesions: An ultrasound study in 154 familiesStroke J. Cereb. Circ.20053615810.1161/01.STR.0000149936.33498.83 – volume: 36 start-page: 5 issue: 1 year: 2005 ident: 71454_CR38 publication-title: Stroke J. Cereb. Circ. doi: 10.1161/01.STR.0000149936.33498.83 – volume: 36 start-page: 540 issue: 3 year: 2005 ident: 71454_CR60 publication-title: Stroke J. Cereb. Circ. doi: 10.1161/01.STR.0000155746.65185.4e – volume: 200 start-page: 213 issue: 1 year: 2008 ident: 71454_CR41 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2007.12.009 – volume: 19 start-page: 218 issue: 2 year: 2016 ident: 71454_CR84 publication-title: Public Health Nutr. doi: 10.1017/S136898001500124X – volume: 68 start-page: 179 issue: Pt 3 year: 2004 ident: 71454_CR23 publication-title: Ann. Hum. Genet. doi: 10.1046/j.1529-8817.2004.00078.x – volume: 56 start-page: 1194 issue: 5 year: 1995 ident: 71454_CR44 publication-title: Am. J. Hum. Genet. – volume: 70 start-page: 717 issue: Pt 6 year: 2006 ident: 71454_CR29 publication-title: Ann. Hum. Genet. doi: 10.1111/j.1469-1809.2006.00280.x – volume: 22 start-page: 843 issue: 5 year: 2002 ident: 71454_CR55 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000015329.15481.E8 – volume: 29 start-page: 631 issue: 3 year: 2006 ident: 71454_CR27 publication-title: Diabetes Care doi: 10.2337/diacare.29.03.06.dc05-0679 – volume: 30 start-page: 841 issue: 4 year: 1999 ident: 71454_CR10 publication-title: Stroke doi: 10.1161/01.STR.30.4.841 – volume: 29 start-page: 379 issue: 3 year: 2017 ident: 71454_CR19 publication-title: Aging Clin. Exp. Res. doi: 10.1007/s40520-016-0575-9 – volume: 27 start-page: 833 issue: 5 year: 1996 ident: 71454_CR53 publication-title: Stroke J. Cereb. Circ. doi: 10.1161/01.STR.27.5.833 – volume: 182 start-page: 307 issue: 2 year: 2005 ident: 71454_CR25 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2005.02.015 – volume: 14 start-page: 1132110 year: 2023 ident: 71454_CR73 publication-title: Front Genet doi: 10.3389/fgene.2023.1132110 – volume: 33 start-page: 1876 issue: 7 year: 2002 ident: 71454_CR56 publication-title: Stroke J. Cereb. Circ. doi: 10.1161/01.STR.0000019909.71547.AA – volume: 102 start-page: 835 issue: 7 year: 2008 ident: 71454_CR31 publication-title: Am. J. Cardiol. doi: 10.1016/j.amjcard.2008.05.049 – volume: 21 start-page: 93 issue: 2 year: 2008 ident: 71454_CR16 publication-title: J. Am. Soc. Echocardiogr. Off. Publ. Am. Soc. Echocardiogr. doi: 10.1016/j.echo.2007.11.011 – volume: 154 start-page: 681 issue: 3 year: 2001 ident: 71454_CR21 publication-title: Atherosclerosis doi: 10.1016/S0021-9150(00)00586-4 – volume: 24 start-page: 511 issue: 5 year: 2014 ident: 71454_CR77 publication-title: Nutr. Metabol. Cardiovasc. Dis. NMCD doi: 10.1016/j.numecd.2013.10.031 – volume: 45 start-page: 203 issue: 3 year: 2015 ident: 71454_CR3 publication-title: Neuroepidemiology doi: 10.1159/000441103 – volume: 17 start-page: 177 issue: 3 year: 2014 ident: 71454_CR42 publication-title: Twin Res. Hum. Genet. doi: 10.1017/thg.2014.19 – volume: 168 start-page: 1016 issue: 9 year: 2008 ident: 71454_CR67 publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwn211 – ident: 71454_CR6 – volume: 58 start-page: 112 issue: 2 year: 2004 ident: 71454_CR24 publication-title: Hum. Hered. doi: 10.1159/000083032 – volume: 22 start-page: 506 issue: 3 year: 2002 ident: 71454_CR47 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/hq0302.104906 – volume: 40 start-page: 2307 issue: 7 year: 2009 ident: 71454_CR68 publication-title: Stroke J. Cereb. Circ. doi: 10.1161/STROKEAHA.109.554121 – volume: 20 start-page: 248 issue: 3 year: 2007 ident: 71454_CR64 publication-title: Am. J. Hypertens. doi: 10.1016/j.amjhyper.2006.09.005 – volume: 12 start-page: e059910 issue: 9 year: 2022 ident: 71454_CR72 publication-title: BMJ Open doi: 10.1136/bmjopen-2021-059910 – volume: 53 start-page: 1029 issue: 4 year: 2002 ident: 71454_CR22 publication-title: Cardiovasc. Res. doi: 10.1016/S0008-6363(01)00534-X – volume: 109 start-page: 1089 issue: 9 year: 2004 ident: 71454_CR14 publication-title: Circulation doi: 10.1161/01.CIR.0000120708.59903.1B – volume: 231 start-page: 120 issue: 1 year: 2013 ident: 71454_CR70 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2013.09.005 – volume: 28 start-page: 1007 issue: 12 year: 2001 ident: 71454_CR54 publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1046/j.1440-1681.2001.03576.x – volume: 102 start-page: 771 issue: 4 year: 2015 ident: 71454_CR85 publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.115.112151 – volume: 2 start-page: 988 issue: 8566 year: 1987 ident: 71454_CR43 publication-title: Lancet doi: 10.1016/S0140-6736(87)92557-8 – volume: 11 start-page: 13 issue: 4 year: 2021 ident: 71454_CR20 publication-title: Biomedicine (Taipei) doi: 10.37796/2211-8039.1174 – volume: 23 start-page: 492 issue: 4 year: 2013 ident: 71454_CR69 publication-title: Ethn. Dis. – volume: 35 start-page: 2243 issue: 10 year: 2004 ident: 71454_CR59 publication-title: Stroke J. Cereb. Circ. doi: 10.1161/01.STR.0000142132.20442.d8 – volume: 17 start-page: e0262395 issue: 1 year: 2022 ident: 71454_CR50 publication-title: PloS One doi: 10.1371/journal.pone.0262395 – volume: 25 start-page: 329 issue: 2 year: 2007 ident: 71454_CR40 publication-title: J. Hypertens. doi: 10.1097/HJH.0b013e328011753e – volume: 43 start-page: 117 issue: 2 year: 2008 ident: 71454_CR65 publication-title: Lipids doi: 10.1007/s11745-007-3138-1 – volume: 189 start-page: 169 issue: 1 year: 2006 ident: 71454_CR26 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2005.11.030 – volume: 24 start-page: 2168 issue: 11 year: 2004 ident: 71454_CR36 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000143856.01669.e7 – volume: 115 start-page: 459 issue: 4 year: 2007 ident: 71454_CR12 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.628875 – volume: 36 start-page: 2215 issue: 10 year: 2005 ident: 71454_CR61 publication-title: Stroke J. Cereb. Circ. doi: 10.1161/01.STR.0000182254.47941.96 – volume: 24 start-page: 62 issue: 1 year: 2015 ident: 71454_CR83 publication-title: Tob. Control doi: 10.1136/tobaccocontrol-2013-051004 – ident: 71454_CR7 – volume: 24 start-page: 2385 issue: 10 year: 2015 ident: 71454_CR80 publication-title: J. Stroke Cerebrovas. Dis. Off. J. Natl. Stroke Assoc. doi: 10.1016/j.jstrokecerebrovasdis.2015.06.039 – volume: 12 start-page: e0178815 issue: 6 year: 2017 ident: 71454_CR34 publication-title: PloS One doi: 10.1371/journal.pone.0178815 – volume: 50 start-page: 130 issue: 1 year: 2004 ident: 71454_CR37 publication-title: Clin. Chem. doi: 10.1373/clinchem.2003.028258 – volume: 16 start-page: 931 issue: 5 year: 2013 ident: 71454_CR33 publication-title: Twin Res. Hum. Genet. doi: 10.1017/thg.2013.58 – volume: 36 start-page: 2351 issue: 11 year: 2005 ident: 71454_CR62 publication-title: Stroke J. Cereb. Circ. doi: 10.1161/01.STR.0000185719.66735.dd – volume: 17 start-page: 525 issue: 3 year: 2009 ident: 71454_CR32 publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2008.556 – volume: 197 start-page: 814 issue: 2 year: 2008 ident: 71454_CR75 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2007.07.030 – volume: 357 start-page: 101 issue: 9250 year: 2001 ident: 71454_CR51 publication-title: Lancet doi: 10.1016/S0140-6736(00)03541-8 – volume: 8 start-page: 352 issue: 4 year: 2007 ident: 71454_CR30 publication-title: Genes Immun. doi: 10.1038/sj.gene.6364395 – volume: 101 start-page: 1546 issue: 13 year: 2000 ident: 71454_CR46 publication-title: Circulation doi: 10.1161/01.CIR.101.13.1546 – volume: 116 start-page: 839 issue: 6 year: 2008 ident: 71454_CR49 publication-title: Environ. Health Perspect. doi: 10.1289/ehp.10754 – volume: 385 start-page: 117 issue: 9963 year: 2015 ident: 71454_CR2 publication-title: Lancet doi: 10.1016/S0140-6736(14)61682-2 – volume: 45 start-page: 161 issue: 3 year: 2015 ident: 71454_CR4 publication-title: Neuroepidemiology doi: 10.1159/000441085 – volume: 39 start-page: 2282 issue: 24 year: 2018 ident: 71454_CR78 publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehy165 – volume: 96 start-page: 1432 issue: 5 year: 1997 ident: 71454_CR8 publication-title: Circulation doi: 10.1161/01.CIR.96.5.1432 – volume: 146 start-page: 483 issue: 6 year: 1997 ident: 71454_CR9 publication-title: Am. J. Epidemiol. doi: 10.1093/oxfordjournals.aje.a009302 – volume: 4 start-page: 599 issue: 3 year: 2006 ident: 71454_CR52 publication-title: J. Thromb. Haemost. JTH doi: 10.1111/j.1538-7836.2005.01778.x – volume: 6 issue: 2 year: 2017 ident: 71454_CR71 publication-title: J. Am. Heart Assoc. doi: 10.1161/JAHA.116.004757 – volume: 349 start-page: 1436 issue: 9063 year: 1997 ident: 71454_CR5 publication-title: Lancet doi: 10.1016/S0140-6736(96)07495-8 – volume: 245 start-page: 171 year: 2016 ident: 71454_CR18 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2015.12.020 – volume: 59 start-page: 1191 issue: 11 year: 2006 ident: 71454_CR28 publication-title: J. Clin. Epidemiol. doi: 10.1016/j.jclinepi.2006.02.015 – volume: 9 start-page: 97 issue: 2 year: 2002 ident: 71454_CR82 publication-title: J. Cardiovasc. Risk doi: 10.1177/174182670200900205 – volume: 22 start-page: 590 issue: 6 year: 2015 ident: 71454_CR81 publication-title: J. Atheroscler. Thromb. doi: 10.5551/jat.23580 – volume: 28 start-page: 1882 issue: 8 year: 2005 ident: 71454_CR63 publication-title: Diabetes Care doi: 10.2337/diacare.28.8.1882 – volume: 365 start-page: 213 issue: 3 year: 2011 ident: 71454_CR13 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1012592 – volume: 375 start-page: 132 issue: 9709 year: 2010 ident: 71454_CR17 publication-title: Lancet doi: 10.1016/S0140-6736(09)61717-7 – volume: 7 start-page: 600 issue: 7 year: 2006 ident: 71454_CR39 publication-title: Genes Immun. doi: 10.1038/sj.gene.6364330 – volume: 198 start-page: 160 issue: 1 year: 2008 ident: 71454_CR66 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2007.09.027 – volume: 110 start-page: 57 issue: 1 year: 2003 ident: 71454_CR48 publication-title: Thromb. Res. doi: 10.1016/S0049-3848(03)00288-3 – volume: 134 start-page: 250 issue: 3 year: 1991 ident: 71454_CR15 publication-title: Am. J. Epidemiol. doi: 10.1093/oxfordjournals.aje.a116078 – volume: 18 start-page: 1559 issue: 10 year: 1998 ident: 71454_CR45 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.18.10.1559 – volume: 34 start-page: 397 issue: 2 year: 2003 ident: 71454_CR58 publication-title: Stroke J. Cereb. Circ. doi: 10.1161/01.STR.0000048214.56981.6F – volume: 25 start-page: 1581 issue: 8 year: 1994 ident: 71454_CR11 publication-title: Stroke doi: 10.1161/01.STR.25.8.1581 – volume: 19 start-page: 1161 issue: 5 year: 2012 ident: 71454_CR76 publication-title: Eur. J. Prev. Cardiol. doi: 10.1177/1741826711422763 – volume: 7 start-page: 239 year: 2007 ident: 71454_CR79 publication-title: BMC Public Health doi: 10.1186/1471-2458-7-239 – volume: 22 start-page: 1698 issue: 10 year: 2002 ident: 71454_CR57 publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000032656.91352.5E – volume: 166 start-page: 137 issue: 1 year: 2003 ident: 71454_CR74 publication-title: Atherosclerosis doi: 10.1016/S0021-9150(02)00317-9 – volume: 169 start-page: 279 issue: 2 year: 2003 ident: 71454_CR35 publication-title: Atherosclerosis doi: 10.1016/S0021-9150(03)00192-8 – ident: 71454_CR1 |
| SSID | ssj0000529419 |
| Score | 2.438545 |
| Snippet | Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity... Abstract Carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, has been found to be associated with incident stroke. High-sensitivity... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 20440 |
| SubjectTerms | 692/308/174 692/699/75 Adult Aged Arteriosclerosis Atherosclerosis Atherosclerosis - genetics C-reactive protein C-Reactive Protein - analysis Carotid Intima-Media Thickness China - epidemiology Community involvement Correlation coefficient CRP East Asian People - genetics Female Fibrinogen Fibrinogen - analysis Genetic factors Genetic Predisposition to Disease Genetic variability Heritability Humanities and Social Sciences Humans Inflammation - genetics Intima-media thickness Male Middle Aged multidisciplinary Offspring Population genetics Population studies Risk Factors Science Science (multidisciplinary) |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrR1NSx0xMIhQ8FJsq3WtLSl408XdJC_JHrVUHoX2VMFbyOaDLsV94q4H_70zyb6nT1u8eNnDZkKG-cjMMJMZQg5bzJUJZcvIgihFBJVqeQRZBmMcnKqZT8WYP3_J-YX4cTm7fDTqC2vCcnvgTLiTxkoPJkjHSjnRRKdD66WvuGcsasdavH3B5j0KpnJXb9aIupleyVRcnwxgqfA1GcPyQzETpV6zRKlh_7-8zOfFkk8ypskQnW-Tt5MHSU8z5u_IRujfkzd5puTdB3IzDxjvp5rXO7qIFAfzjJ2nXT92V7ZMT0UoVrn_xVuO2h6XIgjGVUq402kCD25N3uFigGPg2w0ARy3FidthCPR6Nfprh1ycf__9bV5OgxVKICEbSxkb1bTSax846HScWeWsF20jsP06a1wdJRNeKgf-i5ZtFUFzPUJBMOiC47tks1_0YY9Q2F7V1teqYhEibWalFpb5KJX1QcxUQY6WRDbXuX-GSXlvrk1miQGWmMQSowtyhnxYQWLv6_QDJMJMEmFekoiCHCy5aCaFHAzmMTj4fgrO-LpaBlXC_Ijtw-I2w-CwUA0wHzPTV5iAG8kU3I4F0WvisIbq-krf_UntuuuaK4yKC3K8lJwHvP5Pi_3XoMUnssVQ5DEDxg_I5nhzGz6DFzW2X5LC3APD9hqH priority: 102 providerName: Directory of Open Access Journals – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDLfGEBIviG8KAwWJNyi0aS5JHxACxHRCGk-ctLcobRKoYO24dtLuv5-dtocODl760DhqEtvxL7VjA7yoyFcmlE0D9yIVAVWqKgLKMhpjX6ucuxiMefJFLlfi8-ni9ADmckfTAvZ7j3ZUT2q1_vn68tfmHSr82_HKuH7ToxGii2KcIgvFQqT6GlxHy6RIUU8muD_m-ualyMvp7sz-rjv2Kabx34c9_w6h_MOPGs3T8W24NeFK9n4UhDtw4Nu7cGOsNLm5B-ulp78AMRJ2w7rAqFzP0DjWtENzZtN4gYRR7PsP2vuYbakpoLicRTc8m-ryUNeIGbseP4PPpkc6ZhnV4fa9Z-fbgmD3YXX86evHZTqVW0hrUfIhlaFUZSWddr5ATQ8Lq2rrRFUKSsrOyzoPkgsnVY2oRssqC6jPjqjwiFj7ungAh23X-kfAsHuWW5erjAc8f3MrtbDcBams82KhEng5L7I5H7NqmOgNL7QZWWKQJSayxOgEPhAftpSUETu-6NbfzKRgprTSIVTRIVM4nVBrXznpssJxHnTNqwSOZi6aWcoMeTcKRIQKv_F824wKRl4T2_ruYqShEqIaaR6OTN-OBMElV7hnJqB3xGFnqLstbfM9JvHO80LRWTmBV7Pk_B7Xv9fi8f-n8QRuchJm8ngVR3A4rC_8U0RNQ_UsqsIVGtcUUg priority: 102 providerName: Scholars Portal – databaseName: Springer Nature OA Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR1Nb9UwzBpDSFwQ3xQGChI3qGiTvCQ9whPTExKcmLRblDYJVGjt9Nod9u-x0w_0YBy49NA4ShrbsV1_AbypyVcmtcsjDzKXEVmqFhFpGYVxaHTJfQrG_PJV7c7k5_PN-RHwJRcmBe2nkpbpml6iw94PKGgoGYxT9KDcyNzcgttUup2oequ2638V8lzJsprzYwphbph6IINSqf6b9Mu_wyT_8JUmEXR6H-7NuiP7MO32ARyF7iHcmbpJXj-C_S6QpZ-iXa9ZHxm15Blbz9pubC9cnpJEGMW3_6T7jbmOhiKSxEVytbO59w5NTXphP-Ay-GwHhGOOUa_tMAR2uTb9egxnp5--bXf53FIhb2TFx1zFSle18sYHgdwcN043zsu6klR4nVdNGRWXXukGNRej6iIiz3qCQjOwCY14Asdd34VnwHB6UTpf6oJHtLG5U0Y67qPSzge50Rm8XQ7ZXk6VM2zyeAtjJ5RYRIlNKLEmg4-EhxWSql6nF_3-u52pwFZOeVRHTCw0fk5sTKi98oXwnEfT8DqDkwWLdmbFwZIHQ6DWp3GN1-swMhF5RlwX-qsJhtqEGoR5OiF93QkqkFzjvZiBOSCHg60ejnTtj1SouyyFJns4g3cL5fze17_P4vn_gb-Au5yIm7xc4gSOx_1VeIma0li_SqzxCzqgDwA priority: 102 providerName: Springer Nature |
| Title | Heritability of carotid intima-media thickness and inflammatory factors of atherosclerosis in a Chinese population |
| URI | https://link.springer.com/article/10.1038/s41598-024-71454-8 https://www.ncbi.nlm.nih.gov/pubmed/39227703 https://www.proquest.com/docview/3100364478 https://www.proquest.com/docview/3100561288 https://pubmed.ncbi.nlm.nih.gov/PMC11371917 https://doaj.org/article/9a6d2448f07c49fc8ebd6d03d22f8c2b |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swEBdby2AvY9_z1gUN9raZ2rIiyU8jDS0h0DK2FfImZH2sZtTO4vSh__3uZMcl-3pxwDoT2XenO92d7kfI-wpzZVyaNDDPUx5ApaoigCyDMfZW5szFYszzC7G45MvVdDUE3LqhrHK3JsaF2rUWY-THGIguwHhL9Wn9M0XUKMyuDhAa98khti7Dki65kmOMBbNYPC-HszJZoY47sFd4poxhESKf8lTt2aPYtv9vvuafJZO_5U2jOTp7TB4NfiSd9Yx_Qu755il50CNL3j4jm4XHXX-sfL2lbaAIz7OtHa2bbX1t0nhghGKt-w9c66hpcCiAeFzHtDsdcHjw0egjth38DVzrDuiooYi77TtP1yMA2HNyeXb6bb5IB3iF1PKSbVMRSllWwinnC9DsMDXSGserkmMTdlbaPAjGnZAWvBglqiyA_jqkgi2h9bZ4QQ6atvGvCIXHs9y4XGYswH6bGaG4YS4IaZznU5mQD7uPrNd9Fw0ds9-F0j1LNLBER5ZolZAT5MNIiR2w4412810PCqVLIxy4JipkEl4nWOUrJ1xWOMaCsqxKyNGOi3pQy07fCVFC3o3DoFCYJTGNb296GoQMVUDzsmf6OBNwJpmENTIhak8c9qa6P9LUV7Fpd54XEvfGCfm4k5y7ef37W7z-_2u8IQ8Z-hmxAvOIHGw3N_4teEnbahJVYUIOZ7Pl1yX8npxefP4Cd-diPomRB7iec_ULJ0YW5g |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Nb9MwFH8anRBcEN8EBhgJThAtcdzYOSDEYFPHtgqhTdotOLENFVpSmkyo_xR_I-85Safyddulh_qldfy-_Z79A3heUK1MSB06bkUoHKpUkTiUZXTGtpQxN74Z82iaTk7Eh9Px6Qb8HM7CUFvlYBO9oTZ1SXvk27QRnaDzlurN_HtIqFFUXR0gNDqxOLDLH5iyNa_33yN_X3C-t3v8bhL2qAJhKTLehqnLZFakRhmboEC7sZalNqLIBN09zrMydikXJpUlOm-VFpFDsTVEhZlQacsEf_cKbIoEU5kRbO7sTj9-Wu3qUN1MxFl_OidK1HaDHpJOsXFqexRjEao1D-iBAv4W3f7ZpPlbpdY7wL2bcKOPXNnbTtRuwYatbsPVDstyeQcWE0v7DL7XdslqxwgQqJ0ZNqva2ZkO_REVRt3138i6Ml3RkEOBPPOFftYj_9CjPiqtG_wb_Jw1SMc0I6Rv21g2X0GO3YWTS1n6ezCq6so-AIaPR7E2sYy4wwyf61QJzY1LpTZWjGUAL4dFzufdvR25r7cnKu9YkiNLcs-SXAWwQ3xYUdKd2_6LevEl71U4z3RqMBhSLpL4Oq5UtjCpiRLDuVMlLwLYGriY94agyS_ENoBnq2FUYarL6MrW5x0NgZQqpLnfMX01EwxfuUSrHIBaE4e1qa6PVLOv_prwOE4kZeMBvBok52Je_16Lh_9_jadwbXJ8dJgf7k8PHsF1ToJN9bVkC0bt4tw-xhitLZ70isHg82Xr4i_Hlk7r |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwEB4ti0BcEG8CCxgJThA1cdzYOSAELFWXhRUHVurNOLENFdqkNF2h_jV-HTNO0lV53fbSQz1pHc83nrFn7A_gSUm5MiFN7LkTsfBoUmXmEcvojF0lU25DMeaHo3x6LN7NxrMd-DmchaGyymFODBO1bSraIx_RRnSGzluqke_LIj7uT14uvsfEIEWZ1oFOo4PIoVv_wOVb--JgH3X9lPPJ209vpnHPMBBXouCrOPeFLMrcKusyBLcfG1kZK8pC0D3kvKhSn3Nhc1mhI1d5mXiEsCUpXBVVrsrwdy_ARZmNU7IxOZOb_R3KoIm06M_pJJkategr6TwbpwJIMRax2vKFgTLgb3Hun-Wav-VsgyucXIOrfQzLXnWguw47rr4BlzpWy_VNWE4d7TiEqts1azwjaqDV3LJ5vZqfmDgcVmFUZ_-N5llmamryCM2TkPJnPQcQPRri06bFv8HPeYtyzDDi_HatY4sN-dgtOD6Xgb8Nu3VTu7vA8PEkNTaVCfe41ucmV8Jw63NprBNjGcGzYZD1orvBQ4fMe6Z0pxKNKtFBJVpF8Jr0sJGk27fDF83yi-6NWRcmtxgWKZ9IfB1fKVfa3CaZ5dyripcR7A1a1P2U0OozAEfweNOMxkwZGlO75rSTIbpShTJ3OqVveoKBLJc4P0egtuCw1dXtlnr-NVwYnqaZpHV5BM8H5Jz1699jce__r_EILqMF6vcHR4f34QonXFOiLduD3dXy1D3AYG1VPgxWweDzeZvhL6EMUbs |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Heritability+of+carotid+intima-media+thickness+and+inflammatory+factors+of+atherosclerosis+in+a+Chinese+population&rft.jtitle=Scientific+reports&rft.au=Li%2C+Tsai-Chung&rft.au=Lin%2C+Cheng-Chieh&rft.au=Liu%2C+Chiu-Shong&rft.au=Lin%2C+Chih-Hsueh&rft.date=2024-09-03&rft.pub=Nature+Publishing+Group&rft.eissn=2045-2322&rft.volume=14&rft.issue=1&rft.spage=20440&rft_id=info:doi/10.1038%2Fs41598-024-71454-8&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |