Analysis of transcriptomic data reveals the landscape of cholesterol metabolism in prostate cancer and impact of related signature on survival

• Published in: Discover. Oncology Vol. 15; no. 1; pp. 777 - 24
• Main Authors: Sun, Jian-Xuan, An, Ye, Xu, Meng-Yao, Ma, Si-Yang, Liu, Chen-Qian, Xu, Jin-Zhou, Xia, Qi-Dong, Wang, Shao-Gang
• Format: Journal Article
• Language: English
• Published: New York Springer US 18.12.2024; Springer Nature B.V; Springer
• Subjects: Androgens; Cancer Research; Cancer therapies; Cell growth; Chemotherapy; Cholesterol; Cholesterol metabolism; Genes; Immunotherapy; Internal Medicine; Medical prognosis; Medicine; Medicine & Public Health; Metabolism; Molecular Medicine; Mortality; Oncology; Penicillin; Prostate cancer; Proteins; Radiation therapy; Radiotherapy; Statins; Surgical Oncology; Tumor microenvironment; Tumor mutation burden; United States > US; China; Chemotherapy; Tumor microenvironment; Cholesterol metabolism; Prostate cancer; Immunotherapy; Tumor mutation burden

Background Cholesterol metabolism is essential for the development and progression of prostate cancer (PCa). Our previous study provided a new insight of cholesterol metabolism in the systematic management of PCa. However, the comprehensive role of cholesterol metabolism in PCa remains unclear. Meth...