Acute severe hepatitis outbreak in children: A perfect storm. What do we know, and what questions remain?

• Published in: Frontiers in pharmacology Vol. 13; p. 1062408
• Main Authors: Matthews, Philippa C., Campbell, Cori, Săndulescu, Oana, Matičič, Mojca, Ruta, Simona Maria, Rivero-Juárez, Antonio, van Welzen, Berend Joost, Tan, Boun Kim, Garcia, Federico, Gherlan, George Sebastian, Çınar, Güle, Hasanoğlu, İmran, Gmizić, Ivana, Nicolini, Laura Ambra, Santos, Lurdes, Sargsyants, Narina, Velikov, Petar, Habibović, Selma, Fourati, Slim, Židovec-Lepej, Snježana, Herder, Vanessa, Dudman, Susanne, Miron, Victor Daniel, Irving, William, Şahin, Gülşen Özkaya
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.11.2022
• Subjects: adeno-associated virus; adenovirus; epidemiology; hepatitis; outbreak; paediatric; Pharmacology; epidemiology; liver; adenovirus; aetiology; outbreak; adeno-associated virus; hepatitis; paediatric

During the first half of 2022, the World Health Organization reported an outbreak of acute severe hepatitis of unknown aetiology (AS-Hep-UA) in children, following initial alerts from the United Kingdom (UK) where a cluster of cases was first observed in previously well children aged <6 years. Sp...