Controllability of nonlinear epileptic-seizure spreading dynamics in large-scale subject-specific brain networks

• Published in: Scientific reports Vol. 15; no. 1; pp. 6467 - 37
• Main Authors: Moosavi, S. Amin, Feldman, Jordan S., Truccolo, Wilson
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 639/766/530/2801; 639/766/530/2803; Brain - diagnostic imaging; Brain - physiopathology; Convulsions & seizures; Electric Stimulation; Electrical stimuli; Electroencephalography; Epilepsy; Epilepsy - physiopathology; Excitability; Feedback; Humanities and Social Sciences; Humans; Information processing; Latency; Models, Neurological; multidisciplinary; Nerve Net - physiopathology; Nonlinear Dynamics; Phase transitions; Prevention; Science; Science (multidisciplinary); Seizures; Seizures - physiopathology; Sensorimotor system

Closed-loop electrical stimulation has become an important alternative to resective surgery for control of pharmacologically-resistant focal epileptic seizures. Seizure spread across large-scale brain networks, rather than its focal onset, is what commonly leads to major disruptions in sensorimotor...