A 3-gene signature comprising CDH4, STAT4 and EBV-encoded LMP1 for early diagnosis and predicting disease progression of nasopharyngeal carcinoma

• Published in: Discover. Oncology Vol. 14; no. 1; pp. 119 - 14
• Main Authors: Liu, Shu-Chen, Wang, Chun-I, Liu, Tzu-Tung, Tsang, Ngan-Ming, Sui, Yun-Hua, Juang, Jyh-Lyh
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2023; Springer Nature B.V; Springer
• Subjects: Accuracy; Biopsy; Cancer; Cancer Research; CDH4; CYLD; Discriminant analysis; EBV-encoded LMP1; Epstein-Barr virus; Genes; Infections; Internal Medicine; Lymphoma; Medical diagnosis; Medical prognosis; Medicine; Medicine & Public Health; Molecular Medicine; Nasopharyngeal carcinoma; Oncology; Pathogenesis; Patients; Proteins; Radiotherapy; Regression analysis; STAT4; Surgical Oncology; Throat cancer; Tumorigenesis; Tumors; Viral infections; Taiwan; Nasopharyngeal carcinoma; STAT4; EBV-encoded LMP1; CYLD; CDH4

Purpose Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular diagnostic method for early detection of NPC in clinical biopsies. Methods The transcriptomic data of primary NPC cell strains were use...