A 3-gene signature comprising CDH4, STAT4 and EBV-encoded LMP1 for early diagnosis and predicting disease progression of nasopharyngeal carcinoma

Purpose Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular diagnostic method for early detection of NPC in clinical biopsies. Methods The transcriptomic data of primary NPC cell strains were use...

Full description

Saved in:
Bibliographic Details
Published inDiscover. Oncology Vol. 14; no. 1; pp. 119 - 14
Main Authors Liu, Shu-Chen, Wang, Chun-I, Liu, Tzu-Tung, Tsang, Ngan-Ming, Sui, Yun-Hua, Juang, Jyh-Lyh
Format Journal Article
LanguageEnglish
Published New York Springer US 01.07.2023
Springer Nature B.V
Springer
Subjects
Accuracy
Biopsy
Cancer
Cancer Research
CDH4
CYLD
Discriminant analysis
EBV-encoded LMP1
Epstein-Barr virus
Genes
Infections
Internal Medicine
Lymphoma
Medical diagnosis
Medical prognosis
Medicine
Medicine & Public Health
Molecular Medicine
Nasopharyngeal carcinoma
Oncology
Pathogenesis
Patients
Proteins
Radiotherapy
Regression analysis
STAT4
Surgical Oncology
Throat cancer
Tumorigenesis
Tumors
Viral infections
Taiwan
Nasopharyngeal carcinoma
STAT4
EBV-encoded LMP1
CYLD
CDH4
Online AccessGet full text

Cover

Abstract Purpose Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular diagnostic method for early detection of NPC in clinical biopsies. Methods The transcriptomic data of primary NPC cell strains were used as a discovery tool. Linear regression approach was used to define signatures distinctive between early and late stage of NPC. Expressions of candidates were validated with an independent set of biopsies (n = 39). Leave-one-out cross-validation technique was employed to estimate the prediction accuracy on stage classification. The clinical relevance of marker genes was verified using NPC bulk RNA sequencing data and IHC analysis. Results Three genes comprising CDH4, STAT4, and CYLD were found to have a significant differentiating power to separate NPC from normal nasopharyngeal samples and predicting disease malignancy. IHC analyses showed stronger CDH4, STAT4, and CYLD immunoreactivity in adjacent basal epithelium compared with that in tumor cells ( p  < 0.001). EBV-encoded LMP1 was exclusively expressed in NPC tumors. Using an independent set of biopsies, we showed that a model combining CDH4, STAT4, and LMP1 had a 92.86% of diagnostic accuracy, whereas a combination of STAT4 and LMP1 had a 70.59% accuracy for predicting advanced disease. Mechanistic studies suggested that promoter methylation, loss of DNA allele, and LMP1 contributed to the suppressive expression of CDH4, CYLD, and STAT4, respectively. Conclusion A model combining CDH4 and STAT4 and LMP1 was proposed to be a feasible model for diagnosing NPC and predicting late stage of NPC.
AbstractList Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular diagnostic method for early detection of NPC in clinical biopsies.PURPOSENasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular diagnostic method for early detection of NPC in clinical biopsies.The transcriptomic data of primary NPC cell strains were used as a discovery tool. Linear regression approach was used to define signatures distinctive between early and late stage of NPC. Expressions of candidates were validated with an independent set of biopsies (n = 39). Leave-one-out cross-validation technique was employed to estimate the prediction accuracy on stage classification. The clinical relevance of marker genes was verified using NPC bulk RNA sequencing data and IHC analysis.METHODSThe transcriptomic data of primary NPC cell strains were used as a discovery tool. Linear regression approach was used to define signatures distinctive between early and late stage of NPC. Expressions of candidates were validated with an independent set of biopsies (n = 39). Leave-one-out cross-validation technique was employed to estimate the prediction accuracy on stage classification. The clinical relevance of marker genes was verified using NPC bulk RNA sequencing data and IHC analysis.Three genes comprising CDH4, STAT4, and CYLD were found to have a significant differentiating power to separate NPC from normal nasopharyngeal samples and predicting disease malignancy. IHC analyses showed stronger CDH4, STAT4, and CYLD immunoreactivity in adjacent basal epithelium compared with that in tumor cells (p < 0.001). EBV-encoded LMP1 was exclusively expressed in NPC tumors. Using an independent set of biopsies, we showed that a model combining CDH4, STAT4, and LMP1 had a 92.86% of diagnostic accuracy, whereas a combination of STAT4 and LMP1 had a 70.59% accuracy for predicting advanced disease. Mechanistic studies suggested that promoter methylation, loss of DNA allele, and LMP1 contributed to the suppressive expression of CDH4, CYLD, and STAT4, respectively.RESULTSThree genes comprising CDH4, STAT4, and CYLD were found to have a significant differentiating power to separate NPC from normal nasopharyngeal samples and predicting disease malignancy. IHC analyses showed stronger CDH4, STAT4, and CYLD immunoreactivity in adjacent basal epithelium compared with that in tumor cells (p < 0.001). EBV-encoded LMP1 was exclusively expressed in NPC tumors. Using an independent set of biopsies, we showed that a model combining CDH4, STAT4, and LMP1 had a 92.86% of diagnostic accuracy, whereas a combination of STAT4 and LMP1 had a 70.59% accuracy for predicting advanced disease. Mechanistic studies suggested that promoter methylation, loss of DNA allele, and LMP1 contributed to the suppressive expression of CDH4, CYLD, and STAT4, respectively.A model combining CDH4 and STAT4 and LMP1 was proposed to be a feasible model for diagnosing NPC and predicting late stage of NPC.CONCLUSIONA model combining CDH4 and STAT4 and LMP1 was proposed to be a feasible model for diagnosing NPC and predicting late stage of NPC.
Purpose Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular diagnostic method for early detection of NPC in clinical biopsies. Methods The transcriptomic data of primary NPC cell strains were used as a discovery tool. Linear regression approach was used to define signatures distinctive between early and late stage of NPC. Expressions of candidates were validated with an independent set of biopsies (n = 39). Leave-one-out cross-validation technique was employed to estimate the prediction accuracy on stage classification. The clinical relevance of marker genes was verified using NPC bulk RNA sequencing data and IHC analysis. Results Three genes comprising CDH4, STAT4, and CYLD were found to have a significant differentiating power to separate NPC from normal nasopharyngeal samples and predicting disease malignancy. IHC analyses showed stronger CDH4, STAT4, and CYLD immunoreactivity in adjacent basal epithelium compared with that in tumor cells ( p  < 0.001). EBV-encoded LMP1 was exclusively expressed in NPC tumors. Using an independent set of biopsies, we showed that a model combining CDH4, STAT4, and LMP1 had a 92.86% of diagnostic accuracy, whereas a combination of STAT4 and LMP1 had a 70.59% accuracy for predicting advanced disease. Mechanistic studies suggested that promoter methylation, loss of DNA allele, and LMP1 contributed to the suppressive expression of CDH4, CYLD, and STAT4, respectively. Conclusion A model combining CDH4 and STAT4 and LMP1 was proposed to be a feasible model for diagnosing NPC and predicting late stage of NPC.
Abstract Purpose Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular diagnostic method for early detection of NPC in clinical biopsies. Methods The transcriptomic data of primary NPC cell strains were used as a discovery tool. Linear regression approach was used to define signatures distinctive between early and late stage of NPC. Expressions of candidates were validated with an independent set of biopsies (n = 39). Leave-one-out cross-validation technique was employed to estimate the prediction accuracy on stage classification. The clinical relevance of marker genes was verified using NPC bulk RNA sequencing data and IHC analysis. Results Three genes comprising CDH4, STAT4, and CYLD were found to have a significant differentiating power to separate NPC from normal nasopharyngeal samples and predicting disease malignancy. IHC analyses showed stronger CDH4, STAT4, and CYLD immunoreactivity in adjacent basal epithelium compared with that in tumor cells (p < 0.001). EBV-encoded LMP1 was exclusively expressed in NPC tumors. Using an independent set of biopsies, we showed that a model combining CDH4, STAT4, and LMP1 had a 92.86% of diagnostic accuracy, whereas a combination of STAT4 and LMP1 had a 70.59% accuracy for predicting advanced disease. Mechanistic studies suggested that promoter methylation, loss of DNA allele, and LMP1 contributed to the suppressive expression of CDH4, CYLD, and STAT4, respectively. Conclusion A model combining CDH4 and STAT4 and LMP1 was proposed to be a feasible model for diagnosing NPC and predicting late stage of NPC.
Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular diagnostic method for early detection of NPC in clinical biopsies. The transcriptomic data of primary NPC cell strains were used as a discovery tool. Linear regression approach was used to define signatures distinctive between early and late stage of NPC. Expressions of candidates were validated with an independent set of biopsies (n = 39). Leave-one-out cross-validation technique was employed to estimate the prediction accuracy on stage classification. The clinical relevance of marker genes was verified using NPC bulk RNA sequencing data and IHC analysis. Three genes comprising CDH4, STAT4, and CYLD were found to have a significant differentiating power to separate NPC from normal nasopharyngeal samples and predicting disease malignancy. IHC analyses showed stronger CDH4, STAT4, and CYLD immunoreactivity in adjacent basal epithelium compared with that in tumor cells (p < 0.001). EBV-encoded LMP1 was exclusively expressed in NPC tumors. Using an independent set of biopsies, we showed that a model combining CDH4, STAT4, and LMP1 had a 92.86% of diagnostic accuracy, whereas a combination of STAT4 and LMP1 had a 70.59% accuracy for predicting advanced disease. Mechanistic studies suggested that promoter methylation, loss of DNA allele, and LMP1 contributed to the suppressive expression of CDH4, CYLD, and STAT4, respectively. A model combining CDH4 and STAT4 and LMP1 was proposed to be a feasible model for diagnosing NPC and predicting late stage of NPC.
PurposeNasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular diagnostic method for early detection of NPC in clinical biopsies.MethodsThe transcriptomic data of primary NPC cell strains were used as a discovery tool. Linear regression approach was used to define signatures distinctive between early and late stage of NPC. Expressions of candidates were validated with an independent set of biopsies (n = 39). Leave-one-out cross-validation technique was employed to estimate the prediction accuracy on stage classification. The clinical relevance of marker genes was verified using NPC bulk RNA sequencing data and IHC analysis.ResultsThree genes comprising CDH4, STAT4, and CYLD were found to have a significant differentiating power to separate NPC from normal nasopharyngeal samples and predicting disease malignancy. IHC analyses showed stronger CDH4, STAT4, and CYLD immunoreactivity in adjacent basal epithelium compared with that in tumor cells (p < 0.001). EBV-encoded LMP1 was exclusively expressed in NPC tumors. Using an independent set of biopsies, we showed that a model combining CDH4, STAT4, and LMP1 had a 92.86% of diagnostic accuracy, whereas a combination of STAT4 and LMP1 had a 70.59% accuracy for predicting advanced disease. Mechanistic studies suggested that promoter methylation, loss of DNA allele, and LMP1 contributed to the suppressive expression of CDH4, CYLD, and STAT4, respectively.ConclusionA model combining CDH4 and STAT4 and LMP1 was proposed to be a feasible model for diagnosing NPC and predicting late stage of NPC.
ArticleNumber 119
Author Tsang, Ngan-Ming
Juang, Jyh-Lyh
Sui, Yun-Hua
Liu, Tzu-Tung
Liu, Shu-Chen
Wang, Chun-I
Author_xml – sequence: 1
  givenname: Shu-Chen
  surname: Liu
  fullname: Liu, Shu-Chen
  email: jennyliu66@gmail.com
  organization: Department of Biomedical Sciences and Engineering, National Central University
– sequence: 2
  givenname: Chun-I
  surname: Wang
  fullname: Wang, Chun-I
  organization: Department of Biochemistry, School of Medicine, China Medical University
– sequence: 3
  givenname: Tzu-Tung
  surname: Liu
  fullname: Liu, Tzu-Tung
  organization: Department of Biomedical Sciences and Engineering, National Central University
– sequence: 4
  givenname: Ngan-Ming
  surname: Tsang
  fullname: Tsang, Ngan-Ming
  organization: Department of Radiation Oncology, China Medical University Hsinchu Hospital
– sequence: 5
  givenname: Yun-Hua
  surname: Sui
  fullname: Sui, Yun-Hua
  organization: Department of Biomedical Sciences and Engineering, National Central University
– sequence: 6
  givenname: Jyh-Lyh
  surname: Juang
  fullname: Juang, Jyh-Lyh
  email: juang@nhri.edu.tw
  organization: Institute of Molecular and Genomic Medicine, National Health Research Institutes
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37393410$$D View this record in MEDLINE/PubMed
BookMark eNp9ks9uEzEQxleoiJbSF-CALHHhwIL_Ze09oRAKrRQEEoGrNbFnt642dmpvUPsYvDFOUkrLgZPt8W8-j2e-p9VBiAGr6jmjbxil6m1mvFG8plzU5Sgm9fWj6ogrQeuGMnZwb39YneR8SSnlEyYEnTypDoUSrZCMHlW_pkTUPQYk2fcBxk1CYuNqnXz2oSezD2fyNfm2mC4kgeDI6fsfNQYbHToy__yVkS4mgpCGG-I89CFmn3fgOqHzdtxqOJ8RMpZQ7BPm7GMgsSMBclxfQLoJPcJALCTrQ1zBs-pxB0PGk9v1uPr-8XQxO6vnXz6dz6bz2sqWj3Wz1ECVslx3THSS45I2nXMtKsVRUtE6LaXkYikdSg7oGgHQsgZsZ0FrK46r872ui3BpyodXpRYTwZtdIKbeQBq9HdA0LXKkbIltRyWnLVAqnRal71SDVKJovdtrrTfLFTqLYUwwPBB9eBP8henjT8OoYFLrpii8ulVI8WqDeTQrny0OAwSMm2y4FnyilGKyoC__QS_jJoXSqy3FdCtauaVe3C_prpY_oy8A3wM2xZwTdncIo2ZrMbO3mCkWMzuLmeuSJPZJucBlcOnv2__J-g3RoNNG
Cites_doi 10.1002/ijc.2910450116
10.1038/nrc1452
10.1093/carcin/bgl081
10.1002/path.5019
10.1056/NEJMoa032260
10.1098/rstb.2016.0270
10.1038/nature01802
10.1038/labinvest.3700183
10.1158/0008-5472.CAN-05-4399
10.1186/s12957-016-1083-2
10.1093/carcin/bgab075
10.1093/bioinformatics/18.11.1427
10.1038/nature01803
10.1016/S1044579X02000901
10.1038/s41467-018-07660-6
10.1158/1541-7786.MCR-17-0134
10.1084/jem.20082044
10.1128/JVI.75.6.2929-2937.2001
10.1016/j.ijrobp.2017.03.018
10.1093/bioinformatics/17.12.1228
10.1128/JVI.77.7.4139-4148.2003
10.1158/0008-5472.CAN-04-3000
10.1002/path.2487
10.1038/76006
10.4049/jimmunol.0901411
10.1158/0008-5472.CAN-08-3435
10.1016/j.tim.2004.06.005
10.1006/scbi.2001.0410
10.1016/j.canlet.2022.215586
ContentType Journal Article
Copyright The Author(s) 2023
2023. The Author(s).
The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2023
– notice: 2023. The Author(s).
– notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
NPM
3V.
7RV
7X7
7XB
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
KB0
M0S
NAPCQ
PHGZM
PHGZT
PIMPY
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
7X8
5PM
DOA
DOI 10.1007/s12672-023-00735-x
DatabaseName Springer Nature OA Free Journals
CrossRef
PubMed
ProQuest Central (Corporate)
Nursing & Allied Health Database
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Health & Medical Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Central
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest Central (New)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic


PubMed
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2730-6011
EndPage 14
ExternalDocumentID oai_doaj_org_article_69e2e01be9f04209a004d8300708a473
PMC10314886
37393410
10_1007_s12672_023_00735_x
Genre Journal Article
GeographicLocations Taiwan
GeographicLocations_xml – name: Taiwan
GrantInformation_xml – fundername: National Science and Technology Council, Taiwan
  grantid: 110-2314-B-182-003-MY3
– fundername: National Science and Technology Council
  grantid: 109-2314-B-008-001-MY3
– fundername: ;
  grantid: 109-2314-B-008-001-MY3
– fundername: ;
  grantid: 110-2314-B-182-003-MY3
GroupedDBID 0R~
2JY
53G
7RV
7X7
8FI
8FJ
AAJSJ
AAYZJ
ABEEZ
ABUWG
AFBBN
AFKRA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
BENPR
BGNMA
C6C
CCPQU
EBS
FYUFA
GROUPED_DOAJ
HMCUK
M4Y
NAPCQ
NU0
OK1
PGMZT
PIMPY
ROL
RPM
RSV
SOJ
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
NPM
3V.
7XB
8FK
AZQEC
DWQXO
K9.
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c492t-6b8a077c28f13f42eb06fdd9e772e4039d844423b4de42aed63aa916acfca88c3
IEDL.DBID DOA
ISSN 2730-6011
IngestDate Wed Aug 27 01:31:01 EDT 2025
Thu Aug 21 18:37:38 EDT 2025
Fri Jul 11 07:41:49 EDT 2025
Mon Jul 14 07:44:46 EDT 2025
Thu Apr 03 07:04:08 EDT 2025
Tue Jul 01 01:11:09 EDT 2025
Fri Feb 21 02:42:53 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Nasopharyngeal carcinoma
STAT4
EBV-encoded LMP1
CYLD
CDH4
Language English
License 2023. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c492t-6b8a077c28f13f42eb06fdd9e772e4039d844423b4de42aed63aa916acfca88c3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://doaj.org/article/69e2e01be9f04209a004d8300708a473
PMID 37393410
PQID 2831893944
PQPubID 5642930
PageCount 14
ParticipantIDs doaj_primary_oai_doaj_org_article_69e2e01be9f04209a004d8300708a473
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10314886
proquest_miscellaneous_2832577714
proquest_journals_2831893944
pubmed_primary_37393410
crossref_primary_10_1007_s12672_023_00735_x
springer_journals_10_1007_s12672_023_00735_x
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-07-01
PublicationDateYYYYMMDD 2023-07-01
PublicationDate_xml – month: 07
  year: 2023
  text: 2023-07-01
  day: 01
PublicationDecade 2020
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: United States
PublicationTitle Discover. Oncology
PublicationTitleAbbrev Discov Onc
PublicationTitleAlternate Discov Oncol
PublicationYear 2023
Publisher Springer US
Springer Nature B.V
Springer
Publisher_xml – name: Springer US
– name: Springer Nature B.V
– name: Springer
References Busson, Keryer, Ooka, Corbex (CR5) 2004; 12
Liu, Hsu, Chang, Chung, Jiang, OuYang, Yuh, Hsueh, Liu, Tsang (CR23) 2018; 9
Eliopoulos, Young (CR6) 2001; 11
Yao, Zhang, Zhu, Wang, Li, Wen, Li, Tsai, Glaser (CR19) 1990; 45
Lin, Wang, Chen, Wei, Liang, Jan, Jiang (CR1) 2004; 350
Lin, Chan, Chen, Huang, Wu, Hsu, Chuang, Wang (CR18) 1993; 68
Tsao, Tramoutanis, Dawson, Lo, Huang (CR32) 2002; 12
Lin, Wong, Chan, Tzung, Ho, Hsu, Chuang (CR20) 1990; 62
Trompouki, Hatzivassiliou, Tsichritzis, Farmer, Ashworth, Mosialos (CR15) 2003; 424
Liu, Jen, Jiang, Chang, Hsiung, Wang, Juang (CR22) 2009; 69
Lo, Teo, Hui, To, Tsang, Chan, Mak, Lee, Huang (CR26) 2000; 60
Bignell, Warren, Seal, Takahashi, Rapley, Barfoot, Green, Brown, Biggs, Lakhani (CR9) 2000; 25
Chen, Hutt-Fletcher, Cao, Hayward (CR28) 2003; 77
Kim, Le, Yom, Ng, Chan, Bratman, Welch, Divi, Petryshyn, Conley (CR3) 2017; 98
Huen, Henderson, Croom-Carter, Rowe (CR24) 1995; 10
Sabaawy, Ryan, Khiabanian, Pine (CR34) 2021; 42
Miotto, Sabbioni, Veronese, Calin, Gullini, Liboni, Gramantieri, Bolondi, Ferrazzi, Gafa (CR16) 2004; 64
Hellerbrand, Bumes, Bataille, Dietmaier, Massoumi, Bosserhoff (CR10) 2006; 28
Li, Su, Ying, Yu, Mao (CR17) 2017; 15
Zhang, MacIsaac, Zhou, Huang, Xin, Dobson, Yu, Chiang, Fan, Pelletier (CR31) 2017; 15
Young, Rickinson (CR4) 2004; 4
Lo, Chan, Lo, Leung, Zhang, Chan, Lee, Hjelm, Johnson, Huang (CR2) 1999; 59
Wu, Lu, Lee, Hwang, Lin, Wang, Lin (CR21) 2004; 84
Bose, Yap, Fung, Starzcynski, Saleh, Morgan, Dawson, Chukwuma, Maina, Buettner (CR29) 2009; 217
Shinriki, Jono, Maeshiro, Nakamura, Guo, Li, Ueda, Yoshida, Shinohara, Nakayama (CR12) 2018; 244
Chen, Lee, Zong, Borowitz, Ng, Ambinder, Hayward (CR8) 2001; 75
Wang, Lin, Zhou, Chen, Li, Luo, Zhou, Cai (CR13) 2022; 532
Baudis, Cleary (CR27) 2001; 17
Li, Dahiya (CR25) 2002; 18
Sengupta, den Boon, Chen, Newton, Dahl, Chen, Cheng, Westra, Chen, Hildesheim (CR30) 2006; 66
Good, Thieu, Mathur, Yu, Stritesky, Yeh, O’Malley, Perumal, Kaplan (CR33) 2009; 183
Tsao, Tsang, Lo (CR35) 2017; 372
Massoumi, Kuphal, Hellerbrand, Haas, Wild, Spruss, Pfeifer, Fassler, Bosserhoff (CR11) 2009; 206
Tsao, Tramoutanis, Dawson, Lo, Huang (CR7) 2002; 12
Kovalenko, Chable-Bessia, Cantarella, Israel, Wallach, Courtois (CR14) 2003; 424
SC Liu (735_CR23) 2018; 9
YM Lo (735_CR2) 1999; 59
LS Young (735_CR4) 2004; 4
GR Bignell (735_CR9) 2000; 25
M Baudis (735_CR27) 2001; 17
H Chen (735_CR28) 2003; 77
SC Liu (735_CR22) 2009; 69
KT Yao (735_CR19) 1990; 45
AG Eliopoulos (735_CR6) 2001; 11
E Miotto (735_CR16) 2004; 64
DS Huen (735_CR24) 1995; 10
H Chen (735_CR8) 2001; 75
P Busson (735_CR5) 2004; 12
S Shinriki (735_CR12) 2018; 244
S Sengupta (735_CR30) 2006; 66
CT Lin (735_CR20) 1990; 62
L-C Li (735_CR25) 2002; 18
SR Good (735_CR33) 2009; 183
SW Tsao (735_CR35) 2017; 372
L Wang (735_CR13) 2022; 532
HE Sabaawy (735_CR34) 2021; 42
A Kovalenko (735_CR14) 2003; 424
L Zhang (735_CR31) 2017; 15
K-W Lo (735_CR26) 2000; 60
C Hellerbrand (735_CR10) 2006; 28
R Massoumi (735_CR11) 2009; 206
CT Lin (735_CR18) 1993; 68
SW Tsao (735_CR32) 2002; 12
HC Wu (735_CR21) 2004; 84
SW Tsao (735_CR7) 2002; 12
KY Kim (735_CR3) 2017; 98
S Bose (735_CR29) 2009; 217
JC Lin (735_CR1) 2004; 350
E Trompouki (735_CR15) 2003; 424
Z Li (735_CR17) 2017; 15
References_xml – volume: 45
  start-page: 83
  issue: 1
  year: 1990
  end-page: 9
  ident: CR19
  article-title: Establishment and characterization of two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus and derived from nasopharyngeal carcinomas
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910450116
– volume: 4
  start-page: 757
  issue: 10
  year: 2004
  end-page: 68
  ident: CR4
  article-title: Epstein-Barr virus: 40 years on
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc1452
– volume: 62
  start-page: 713
  issue: 6
  year: 1990
  end-page: 24
  ident: CR20
  article-title: Establishment and characterization of two nasopharyngeal carcinoma cell lines
  publication-title: Lab Invest
– volume: 28
  start-page: 21
  issue: 1
  year: 2006
  end-page: 7
  ident: CR10
  article-title: Reduced expression of CYLD in human colon and hepatocellular carcinomas
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgl081
– volume: 244
  start-page: 367
  issue: 3
  year: 2018
  end-page: 79
  ident: CR12
  article-title: Loss of CYLD promotes cell invasion via ALK5 stabilization in oral squamous cell carcinoma
  publication-title: J Pathol
  doi: 10.1002/path.5019
– volume: 60
  start-page: 3348
  issue: 13
  year: 2000
  end-page: 53
  ident: CR26
  article-title: High resolution allelotype of microdissected primary nasopharyngeal carcinoma
  publication-title: Cancer Res
– volume: 350
  start-page: 2461
  issue: 24
  year: 2004
  end-page: 70
  ident: CR1
  article-title: Quantification of plasma Epstein-Barr virus DNA in patients with advanced nasopharyngeal carcinoma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa032260
– volume: 372
  start-page: 20160270
  issue: 1732
  year: 2017
  ident: CR35
  article-title: Epstein-Barr virus infection and nasopharyngeal carcinoma
  publication-title: Philos Trans R Soc Lond B Biol Sci
  doi: 10.1098/rstb.2016.0270
– volume: 424
  start-page: 801
  issue: 6950
  year: 2003
  end-page: 5
  ident: CR14
  article-title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
  publication-title: Nature
  doi: 10.1038/nature01802
– volume: 84
  start-page: 1547
  issue: 12
  year: 2004
  end-page: 56
  ident: CR21
  article-title: MDM2 expression in EBV-infected nasopharyngeal carcinoma cells
  publication-title: Lab Invest
  doi: 10.1038/labinvest.3700183
– volume: 66
  start-page: 7999
  issue: 16
  year: 2006
  end-page: 8006
  ident: CR30
  article-title: Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-05-4399
– volume: 15
  start-page: 26
  issue: 1
  year: 2017
  ident: CR17
  article-title: Study on expression of CDH4 in lung cancer
  publication-title: World J Surg Oncol
  doi: 10.1186/s12957-016-1083-2
– volume: 42
  start-page: 1411
  issue: 12
  year: 2021
  end-page: 9
  ident: CR34
  article-title: JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgab075
– volume: 18
  start-page: 1427
  issue: 11
  year: 2002
  end-page: 31
  ident: CR25
  article-title: MethPrimer: designing primers for methylation PCRs
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/18.11.1427
– volume: 424
  start-page: 793
  issue: 6950
  year: 2003
  end-page: 6
  ident: CR15
  article-title: CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
  publication-title: Nature
  doi: 10.1038/nature01803
– volume: 12
  start-page: 473
  issue: 6
  year: 2002
  end-page: 87
  ident: CR32
  article-title: The significance of LMP1 expression in nasopharyngeal carcinoma
  publication-title: Sem Cancer Biol
  doi: 10.1016/S1044579X02000901
– volume: 9
  start-page: 5105
  issue: 1
  year: 2018
  ident: CR23
  article-title: Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-07660-6
– volume: 15
  start-page: 1722
  issue: 12
  year: 2017
  end-page: 32
  ident: CR31
  article-title: Genomic analysis of nasopharyngeal carcinoma reveals TME-Based subtypes
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-17-0134
– volume: 206
  start-page: 221
  issue: 1
  year: 2009
  end-page: 32
  ident: CR11
  article-title: Down-regulation of CYLD expression by snail promotes tumor progression in malignant melanoma
  publication-title: J Exp Med
  doi: 10.1084/jem.20082044
– volume: 12
  start-page: 473
  issue: 6
  year: 2002
  end-page: 87
  ident: CR7
  article-title: The significance of LMP1 expression in nasopharyngeal carcinoma
  publication-title: Semin Cancer Biol
  doi: 10.1016/S1044579X02000901
– volume: 75
  start-page: 2929
  issue: 6
  year: 2001
  end-page: 37
  ident: CR8
  article-title: Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors
  publication-title: J Virol
  doi: 10.1128/JVI.75.6.2929-2937.2001
– volume: 98
  start-page: 996
  issue: 5
  year: 2017
  end-page: 1001
  ident: CR3
  article-title: Clinical utility of Epstein-Barr virus DNA testing in the treatment of nasopharyngeal carcinoma patients
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2017.03.018
– volume: 10
  start-page: 549
  issue: 3
  year: 1995
  end-page: 60
  ident: CR24
  article-title: The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain
  publication-title: Oncogene
– volume: 17
  start-page: 1228
  issue: 12
  year: 2001
  end-page: 9
  ident: CR27
  article-title: Progenetix.net: an online repository for molecular cytogenetic aberration data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/17.12.1228
– volume: 77
  start-page: 4139
  issue: 7
  year: 2003
  end-page: 48
  ident: CR28
  article-title: A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus
  publication-title: J Virol
  doi: 10.1128/JVI.77.7.4139-4148.2003
– volume: 64
  start-page: 8156
  issue: 22
  year: 2004
  end-page: 9
  ident: CR16
  article-title: Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-04-3000
– volume: 68
  start-page: 716
  issue: 6
  year: 1993
  end-page: 27
  ident: CR18
  article-title: Characterization of seven newly established nasopharyngeal carcinoma cell lines
  publication-title: Lab Invest
– volume: 217
  start-page: 345
  issue: 3
  year: 2009
  end-page: 52
  ident: CR29
  article-title: The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma
  publication-title: J Pathol
  doi: 10.1002/path.2487
– volume: 25
  start-page: 160
  issue: 2
  year: 2000
  end-page: 5
  ident: CR9
  article-title: Identification of the familial cylindromatosis tumour-suppressor gene
  publication-title: Nat Genet
  doi: 10.1038/76006
– volume: 183
  start-page: 3839
  issue: 6
  year: 2009
  end-page: 47
  ident: CR33
  article-title: Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0901411
– volume: 59
  start-page: 1188
  issue: 6
  year: 1999
  end-page: 91
  ident: CR2
  article-title: Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma
  publication-title: Cancer Res
– volume: 69
  start-page: 6122
  issue: 15
  year: 2009
  end-page: 30
  ident: CR22
  article-title: G(alpha)12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-08-3435
– volume: 12
  start-page: 356
  issue: 8
  year: 2004
  end-page: 60
  ident: CR5
  article-title: EBV-associated nasopharyngeal carcinomas: from epidemiology to virus-targeting strategies
  publication-title: Trends Microbiol
  doi: 10.1016/j.tim.2004.06.005
– volume: 11
  start-page: 435
  issue: 6
  year: 2001
  end-page: 44
  ident: CR6
  article-title: LMP1 structure and signal transduction
  publication-title: Semin Cancer Biol
  doi: 10.1006/scbi.2001.0410
– volume: 532
  start-page: 215586
  year: 2022
  ident: CR13
  article-title: CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2022.215586
– volume: 424
  start-page: 793
  issue: 6950
  year: 2003
  ident: 735_CR15
  publication-title: Nature
  doi: 10.1038/nature01803
– volume: 11
  start-page: 435
  issue: 6
  year: 2001
  ident: 735_CR6
  publication-title: Semin Cancer Biol
  doi: 10.1006/scbi.2001.0410
– volume: 244
  start-page: 367
  issue: 3
  year: 2018
  ident: 735_CR12
  publication-title: J Pathol
  doi: 10.1002/path.5019
– volume: 28
  start-page: 21
  issue: 1
  year: 2006
  ident: 735_CR10
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgl081
– volume: 68
  start-page: 716
  issue: 6
  year: 1993
  ident: 735_CR18
  publication-title: Lab Invest
– volume: 12
  start-page: 356
  issue: 8
  year: 2004
  ident: 735_CR5
  publication-title: Trends Microbiol
  doi: 10.1016/j.tim.2004.06.005
– volume: 98
  start-page: 996
  issue: 5
  year: 2017
  ident: 735_CR3
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2017.03.018
– volume: 183
  start-page: 3839
  issue: 6
  year: 2009
  ident: 735_CR33
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0901411
– volume: 84
  start-page: 1547
  issue: 12
  year: 2004
  ident: 735_CR21
  publication-title: Lab Invest
  doi: 10.1038/labinvest.3700183
– volume: 45
  start-page: 83
  issue: 1
  year: 1990
  ident: 735_CR19
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910450116
– volume: 424
  start-page: 801
  issue: 6950
  year: 2003
  ident: 735_CR14
  publication-title: Nature
  doi: 10.1038/nature01802
– volume: 60
  start-page: 3348
  issue: 13
  year: 2000
  ident: 735_CR26
  publication-title: Cancer Res
– volume: 64
  start-page: 8156
  issue: 22
  year: 2004
  ident: 735_CR16
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-04-3000
– volume: 18
  start-page: 1427
  issue: 11
  year: 2002
  ident: 735_CR25
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/18.11.1427
– volume: 15
  start-page: 1722
  issue: 12
  year: 2017
  ident: 735_CR31
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-17-0134
– volume: 12
  start-page: 473
  issue: 6
  year: 2002
  ident: 735_CR32
  publication-title: Sem Cancer Biol
  doi: 10.1016/S1044579X02000901
– volume: 17
  start-page: 1228
  issue: 12
  year: 2001
  ident: 735_CR27
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/17.12.1228
– volume: 69
  start-page: 6122
  issue: 15
  year: 2009
  ident: 735_CR22
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-08-3435
– volume: 59
  start-page: 1188
  issue: 6
  year: 1999
  ident: 735_CR2
  publication-title: Cancer Res
– volume: 62
  start-page: 713
  issue: 6
  year: 1990
  ident: 735_CR20
  publication-title: Lab Invest
– volume: 206
  start-page: 221
  issue: 1
  year: 2009
  ident: 735_CR11
  publication-title: J Exp Med
  doi: 10.1084/jem.20082044
– volume: 372
  start-page: 20160270
  issue: 1732
  year: 2017
  ident: 735_CR35
  publication-title: Philos Trans R Soc Lond B Biol Sci
  doi: 10.1098/rstb.2016.0270
– volume: 25
  start-page: 160
  issue: 2
  year: 2000
  ident: 735_CR9
  publication-title: Nat Genet
  doi: 10.1038/76006
– volume: 4
  start-page: 757
  issue: 10
  year: 2004
  ident: 735_CR4
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc1452
– volume: 77
  start-page: 4139
  issue: 7
  year: 2003
  ident: 735_CR28
  publication-title: J Virol
  doi: 10.1128/JVI.77.7.4139-4148.2003
– volume: 75
  start-page: 2929
  issue: 6
  year: 2001
  ident: 735_CR8
  publication-title: J Virol
  doi: 10.1128/JVI.75.6.2929-2937.2001
– volume: 9
  start-page: 5105
  issue: 1
  year: 2018
  ident: 735_CR23
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-07660-6
– volume: 532
  start-page: 215586
  year: 2022
  ident: 735_CR13
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2022.215586
– volume: 15
  start-page: 26
  issue: 1
  year: 2017
  ident: 735_CR17
  publication-title: World J Surg Oncol
  doi: 10.1186/s12957-016-1083-2
– volume: 10
  start-page: 549
  issue: 3
  year: 1995
  ident: 735_CR24
  publication-title: Oncogene
– volume: 66
  start-page: 7999
  issue: 16
  year: 2006
  ident: 735_CR30
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-05-4399
– volume: 350
  start-page: 2461
  issue: 24
  year: 2004
  ident: 735_CR1
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa032260
– volume: 217
  start-page: 345
  issue: 3
  year: 2009
  ident: 735_CR29
  publication-title: J Pathol
  doi: 10.1002/path.2487
– volume: 42
  start-page: 1411
  issue: 12
  year: 2021
  ident: 735_CR34
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgab075
– volume: 12
  start-page: 473
  issue: 6
  year: 2002
  ident: 735_CR7
  publication-title: Semin Cancer Biol
  doi: 10.1016/S1044579X02000901
SSID ssj0002513305
Score 2.224761
Snippet Purpose Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient...
Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient molecular...
PurposeNasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly efficient...
Abstract Purpose Nasopharyngeal carcinoma is highly metastatic but difficult to detect in its early stages. It is critical to develop a simple and highly...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 119
SubjectTerms Accuracy
Biopsy
Cancer
Cancer Research
CDH4
CYLD
Discriminant analysis
EBV-encoded LMP1
Epstein-Barr virus
Genes
Infections
Internal Medicine
Lymphoma
Medical diagnosis
Medical prognosis
Medicine
Medicine & Public Health
Molecular Medicine
Nasopharyngeal carcinoma
Oncology
Pathogenesis
Patients
Proteins
Radiotherapy
Regression analysis
STAT4
Surgical Oncology
Throat cancer
Tumorigenesis
Tumors
Viral infections
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bb9MwFLZgSIgXxH2BDRmJN2aRxI7tPE3d2FQhipDoUN8i3wJ7WFLaTho_g3_MOY7bqtxeEys5ybnK5_N3CHmtpLHYLWPaVJYJUwtmoe5g0gjX5pbLImJzJh_l-EK8n1WztOG2TLDKdUyMgdr3DvfI30IaLCC31kIcz78znBqF3dU0QuM2uYPUZWjVaqY2eywlDi_Jq3RWZjgxV0pVMkhUDHtUFbvZyUeRtv9vteafkMnf-qYxHZ0_IPdTHUlHg-Ifkluhe0TuTlKn_DH5OaKcgXEEigiNyN5JET4OPg3Po6fvxuKIfp6OpoKaztOzky8MKS198PTD5FNBoZalAcmPqR_AeJfLuHC-wFcgVpqm3g6NEK-B3oP2Le0MTkYwix8gNkjocFhR11-ZJ-Ti_Gx6OmZp_AJzoi5XTFptcqVcqduCt6IMNpet93WAgjyInNdeCwHVmBU-iNIEL7kxUG0a1zqjteNPyV7Xd2GfUMWld1Y7H6ACaitdK6tlgNBRYFtT5xl5s1ZCMx9YNpotnzKqrAGVNVFlzU1GTlBPm5XIkB0v9IuvTXK4RtahDHlhQ91CXMprA9HAa470RtoIxTNysNZyk9x22WyNLCOvNrfB4bCLYrrQX8c1EOaUKmDNs8EoNpJw5BcUBXyP3jGXHVF373SX3yKpN47bgGAqM3K0tqytXP_-F8___xkvyL0yGjviiw_I3mpxHQ6hilrZl9FVfgGMYhnX
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9NAEF6hVkJcEG9MW7RI3OgK78O762OatooQQUikqDdrXxY91KmSVIKf0X_MzNpJlbYcuNpje-x57CfP7DeEfDTaeayWMesqz5SrFfOAO5h2KrSll5rn3pzpNz05U1_Oq_OBJgf3wtyp339ecqGNYLCyMCwqVQzw4m7FpcExDWM93vxPETiopKyGfTEPX7q19mSK_odw5f32yDs10rz0nD4jTwfMSEe9kZ-TR6l7QR5Ph6r4S3IzopKBIySK3RiZqZNiqzjEL9yPjo8n6pD-mI1mirou0pOjnwzpK2OK9Ov0O6eAW2lComMa-8a7i2UWvFrgI7Avmg51HJrbuXoqDzpvaedwCoJb_AG1QcOAg4m6-aV7Rc5OT2bjCRtGLbCgarFi2ltXGhOEbblslUi-1G2MdQLwnVQp62iVAuTlVUxKuBS1dA6QpQttcNYG-ZrsdPMuvSXUSB2DtyEmQDttZWvjrU6QJjiWMG1ZkE9rIzRXPaNGc8udjCZrwGRNNlnzuyBHaKeNJLJh5wPgJM0QXI2uk0gl96luIQeVtYPIj1YilZF1ysiC7K-t3AwhumwAV3EAa7VSBfmwOQ3BhRUT16X5dZaBlGYMB5k3vVNsNJHIJag4vI_dcpctVbfPdBe_MoE3jtaAxKkLcrj2rFu9_v0t3v2f-B55IrLzY2_xPtlZLa7TASColX-fQ-cvGWMTCg
  priority: 102
  providerName: Springer Nature
Title A 3-gene signature comprising CDH4, STAT4 and EBV-encoded LMP1 for early diagnosis and predicting disease progression of nasopharyngeal carcinoma
URI https://link.springer.com/article/10.1007/s12672-023-00735-x
https://www.ncbi.nlm.nih.gov/pubmed/37393410
https://www.proquest.com/docview/2831893944
https://www.proquest.com/docview/2832577714
https://pubmed.ncbi.nlm.nih.gov/PMC10314886
https://doaj.org/article/69e2e01be9f04209a004d8300708a473
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxELagSIgL4s1CiYzEjVrser2295iEVBEiVQUpys3ya0UPbKo0lcrP6D_ujHeTNjzEhWOyVjLrmbG_3fn8DSHvlLQOq2VM28oxYWvBHOAOJq3wTe5KWSRuzuxITk_Ep0W1uNXqCzlhnTxwN3EfZB15zAsX6wbiK68teDXoEmVqtBUq6XzCnnfrYQrXYI5tS_KqPyXTnZXjUnEGWxTD6lTFLnd2oiTY_yeU-TtZ8peKadqIDh-Rhz2CpMPO8sfkTmyfkPuzvkb-lFwNackgLCJFbkbS7aRIHIdsht-j449TcUC_zodzQW0b6GT0jaGYZYiBfp4dFxRQLI0oe0xDR8M7PU8Dz1b4F8iSpn1VhyZyVyfsQZcNbS32RLCrn2A2WOixTVG7_GGfkZPDyXw8ZX3jBeZFzddMOm1zpTzXTVE2gkeXyyaEOgIUjyIv66CFABzmRIiC2xhkaS3gTOsbb7X25XOy1y7b-JJQVcrgnfYhAvZpKl0rp2WERaPAgqbOM_J-4wRz1ulrmBslZXSZAZeZ5DJzmZER-mk7ErWx0xcQMaaPGPOviMnI_sbLpk_YcwMoqwDoVguRkbfby5BqWD-xbVxepDGwwClVwJgXXVBsLSlRWVAUcD96J1x2TN290p5-T3Le2GgDllGZkYNNZN3Y9fe5ePU_5uI1ecBTSiD_eJ_srVcX8Q2grLUbkLtqoQbk3mhydPwFPo3leJCSbJBeiV0DnOglKQ
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELaWRQIuiDeFBYwEJ9YicRzbOSDUfanLtiskuqi3YMcO7IGktF2x-zP4I_xGZpykVXnd9hpbySQznhlnPn9DyAsljcVqGdMmtUyYTDALeQeTRhRlZBMZB2zO6FgOTsS7STrZID-7szAIq-x8YnDUri7wH_lrCIMxxNZMiLfTbwy7RmF1tWuh0ZjFkb_4Dlu2-ZvDPdDvS84P9se7A9Z2FWCFyPiCSatNpFTBdRknpeDeRrJ0LvOQZ3oRJZnTQkCSYYXzghvvZGIMJFGmKAujdZHAfa-QqxB4I9zsqYla_tPh2CwlStuzOc0JPS4VZxAYGdbEUna-Fv9Cm4C_5bZ_QjR_q9OG8Hdwi9xs81babwztNtnw1R1ybdRW5u-SH32aMDBGTxEREthCKcLVwYfA_eju3kBs0w_j_lhQUzm6v_ORIYWm844OR-9jCrkz9Ui2TF0D_judh4nTGT4Csdm0rSXRAClr6ERoXdLKYCcGM7sAsUHCApsjVfVXc4-cXIpi7pPNqq78Q0JVIl1hdeE8ZFxlqjNltfTgqmIso-qoR151SsinDatHvuJvRpXloLI8qCw_75Ed1NNyJjJyhwv17HPeLvBcZp77KLY-K8EPRpkB7-N0gnRK2giV9MhWp-W8dRPzfGXUPfJ8OQwLHKs2pvL1WZgDblWpGOY8aIxiKUmCfIYihvfRa-ayJur6SHX6JZCIY3sPcN6yR7Y7y1rJ9e9v8ej_r_GMXB-MR8N8eHh89Jjc4MHwEdu8RTYXszP_BDK4hX0alg0lny57nf4ChVJXog
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZGJ028IO4UBhgJnpi1xHEd5wGhdm21sbWqoEN7C3bswB5IStuJ7Wfwd_h1nOMkrcrtba-JlZzkXJPz-TuEvIylNtgtY0p3DBM6EcxA3cGkFlkemEiGHpszGsvDU_HurHO2RX42e2EQVtnERB-obZnhP_J9SIMh5NZEiP28hkVM-sO3s28MJ0hhp7UZp1GZyLG7-g6fb4s3R33Q9SvOh4PpwSGrJwywTCR8yaRROojjjKs8jHLBnQlkbm3ioOZ0IogSq4SAgsMI6wTXzspIayiodJZnWqksguveINsxfhW1yHZvMJ68X_3h4Tg6JejUO3Wq_XpcxpxBmmTYIeuwy41s6IcG_K3S_ROw-VvX1ifD4W1yq65iabcyuztkyxV3yc6o7tPfIz-6NGJgmo4iPsRzh1IEr0NEgevRg_6h2KMfpt2poLqwdND7yJBQ0zpLT0aTkEIlTR1SL1NbQQHPF37hbI63QKQ2rTtL1APMKnIRWua00DiXQc-vQGyQMMNRSUX5Vd8np9eimgekVZSFe0RoHEmbGZVZB_VX3lFJbJR0ELhCbKqqoE1eN0pIZxXHR7pmc0aVpaCy1KssvWyTHupptRL5uf2Bcv45rd09lYnjLgiNS3KIikGiIRZZFSG5ktIijtpkt9FyWgeNRbo28TZ5sToN7o49HF248sKvgSAbxyGseVgZxUqSCNkNRQjPozbMZUPUzTPF-RdPKY7DPiCUyzbZayxrLde_38Xj_z_Gc7IDPpqeHI2Pn5Cb3Ns9Ap13SWs5v3BPoZxbmme131Dy6bpd9RduOV09
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+3-gene+signature+comprising+CDH4%2C+STAT4+and+EBV-encoded+LMP1+for+early+diagnosis+and+predicting+disease+progression+of+nasopharyngeal+carcinoma&rft.jtitle=Discover.+Oncology&rft.au=Liu%2C+Shu-Chen&rft.au=Wang%2C+Chun-I&rft.au=Liu%2C+Tzu-Tung&rft.au=Tsang%2C+Ngan-Ming&rft.date=2023-07-01&rft.issn=2730-6011&rft.eissn=2730-6011&rft.volume=14&rft.issue=1&rft.spage=119&rft_id=info:doi/10.1007%2Fs12672-023-00735-x&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2730-6011&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2730-6011&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2730-6011&client=summon