PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia - Beck, Dominik; Cao, Honghui; Tian, Feng; Huang, Yizhou; Jiang, Miao; Zhao, Han; Tai, Xiaolu; Xu, Wenqian; Kosasih, Hansen J.; Kealy, David J.; Zhao, Weiye; Taylor, Samuel J.; et al. (Nature communications, 2024)
Keywords: 45/15; 45/23; 45/43; 45/91; 49/23; 49/39; 64/60; 692/4017; 692/4028/67/1990/283/2125; 692/4028/67/69; 82/58; 96/31; Acute lymphoblastic leukemia; Animals; Apoptosis; Apoptosis - drug effects; Cancer; Cell Line, Tumor; Chromatin; Chromatin - metabolism; Drug Resistance, Neoplasm - genetics; Epigenesis, Genetic - drug effects; Epigenetics; Female; Gene Expression Regulation, Leukemic - drug effects; Glucocorticoid receptors; Glucocorticoids; Glucocorticoids - pharmacology; Humanities and Social Sciences; Humans; Leukemia; Lymphatic leukemia; Lymphocytes; Lymphocytes - drug effects; Lymphocytes - metabolism; Mice; multidisciplinary; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; PU.1 protein; Receptors; Receptors, Glucocorticoid - genetics; Receptors, Glucocorticoid - metabolism; Regulatory mechanisms (biology); Regulatory sequences; Resistance factors; Response Elements; Science; Science (multidisciplinary); Trans-Activators - genetics; Trans-Activators - metabolism; Transcription factors; Xenograft Model Antitumor Assays; Xenotransplantation