Elucidating the gastroprotective mechanisms of Imperata cylindrica Beauv.var. major (Nees) C.E.Hubb through UHPLC-MS/MS and systems network pharmacology

• Published in: Scientific reports Vol. 14; no. 1; pp. 27815 - 14
• Main Authors: Zhou, Jiaxin, Hu, Jianping, Liu, Jiancheng, Zhang, Wenchun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.11.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 631/114; 631/154; 631/1647; 692/4020; 692/420; Acids; AKT protein; Bioactive compounds; Bioinformatics; BMG; Chromatography; Chromatography, High Pressure Liquid - methods; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Gastrointestinal diseases; Gastrointestinal protection; Genes; Herbal medicine; High-performance liquid chromatography; Humanities and Social Sciences; Humans; Imperata cylindrica; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Medicine; Molecular Docking; Molecular Docking Simulation; Molecular modelling; multidisciplinary; Network Pharmacology; p-Hydroxybenzoic acid; Pharmacology; Plant Extracts - chemistry; Plant Extracts - pharmacology; Proteins; Science; Science (multidisciplinary); Signal Transduction - drug effects; Software; Tandem Mass Spectrometry - methods; TCM; Toxicity; Traditional Chinese medicine; UHPLC-MS/MS; Gastrointestinal protection; UHPLC-MS/MS; BMG; Network Pharmacology; Molecular Docking; TCM

Imperata cylindrica Beauv.var. major (Nees) C.E.Hubb., commonly known as BaiMaoGen (BMG), a medicinal and edible traditional Chinese medicinal (TCM) herb commonly used in health supplements, has been observed to offer protective effects against gastrointestinal disorders. However, the specific bioac...