Alendronate partially rescues the periodontal defects in OIM mouse model of osteogenesis imperfecta

• Published in: Scientific reports Vol. 15; no. 1; pp. 88 - 12
• Main Authors: Chen, Po-Jung, Wang, Ke, Lin, Meng-Hsuan, Sharma, Radhika, Kalajzic, Zana, O’Brien, Mara, Yadav, Sumit
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.01.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/136; 692/700; Adaptor Proteins, Signal Transducing - metabolism; Alendronate; Alendronate - pharmacology; Alendronate - therapeutic use; Alendronic acid; Alveolar bone; Alveolar Bone Loss - drug therapy; Alveolar Bone Loss - etiology; Alveolar Bone Loss - metabolism; Alveolar Bone Loss - pathology; Animal models; Animals; Bisphosphonates; Bone Density Conservation Agents - pharmacology; Bone Density Conservation Agents - therapeutic use; Bone growth; Bone loss; Bone mass; Bone resorption; Bones; Cementum; Collagen; Collagen (type I); Collagenase 3; Dental roots; Disease Models, Animal; Euthanasia; Fibers; Humanities and Social Sciences; Immunohistochemistry; Mice; multidisciplinary; Mutation; Orthodontic tooth movement; Orthodontics; Osteoclasts - drug effects; Osteoclasts - metabolism; Osteogenesis; Osteogenesis Imperfecta; Osteogenesis Imperfecta - drug therapy; Osteogenesis Imperfecta - metabolism; Osteogenesis Imperfecta - pathology; Periodontal ligament; Periodontal Ligament - drug effects; Periodontal Ligament - metabolism; Periodontal Ligament - pathology; Periodontium; Phenotypes; Root resorption; Science; Science (multidisciplinary); Sharpey’s fiber; SOST protein; Orthodontic tooth movement; Periodontal ligament; Sharpey’s fiber; Alendronate; Osteogenesis Imperfecta

Osteogenesis imperfecta (OI) is a fairly common generalized connective disorder characterized by low bone mass, bone deformities and impaired bone quality that predisposes affected individuals to musculoskeletal fragility. Periodontal ligament (PDL)-alveolar bone and PDL-cementum entheses’ roles und...