Molecular basis for chromatin binding and regulation of MLL5

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 28; pp. 11296 - 11301
• Main Authors: Ali, Muzaffar, Rincón-Arano, Héctor, Zhao, Wei, Rothbart, Scott B., Tong, Qiong, Parkhurst, Susan M., Strahl, Brian D., Deng, Lih-Wen, Groudine, Mark, Kutateladze, Tatiana G.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 09.07.2013; National Acad Sciences
• Subjects: Amino Acid Sequence; Antibodies; Biological Sciences; Cell cycle; Chromatin; Chromatin - metabolism; Crystal structure; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - metabolism; Drosophila; Genes; Histones; Homeostasis; Humans; Leukemia; Models, Molecular; Molecular Sequence Data; Phosphorylation; Promoter regions; Protein Binding; Protein Conformation; Protein isoforms; Proteins; Sequence Homology, Amino Acid

The human mixed-lineage leukemia 5 (MLL5) protein mediates hematopoietic cell homeostasis, cell cycle, and survival; however, the molecular basis underlying MLL5 activities remains unknown. Here, we show that MLL5 is recruited to gene-rich euchromatic regions via the interaction of its plant homeodo...