NLRP10 maintains epidermal homeostasis by promoting keratinocyte survival and P63-dependent differentiation and barrier function

• Published in: Cell death & disease Vol. 15; no. 10; pp. 759 - 15
• Main Authors: Cho, Yeonhee, Cao, Zhongzheng, Luo, Xin, Tian, Jennifer J., Hukkanen, Renee R., Hussien, Rajaa, Cancilla, Belinda, Chowdhury, Priyanka, Li, Fei, Ma, Shining, LaGory, Edward L., Schroeder, Mark, Dusenberry, Amanda, Marshall, Leslie, Hawkins, Jenn, van Lookeren Campagne, Menno, Zhou, Yi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.10.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/107; 13/109; 13/2; 13/51; 13/95; 14; 14/19; 38/39; 38/91; 42/41; 631/136/142; 631/45/608; 631/80/304; 631/80/82/23; 692/699/249/2510/1415; 82/29; 82/80; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Antibodies; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Atopic dermatitis; Biochemistry; Biomedical and Life Sciences; Caspase-8; Cell activation; Cell Biology; Cell Culture; Cell death; Cell Differentiation; Cell Survival; Dermatitis; Dermatitis, Atopic - genetics; Dermatitis, Atopic - metabolism; Dermatitis, Atopic - pathology; Epidermis - metabolism; Epidermis - pathology; Genome-wide association studies; Homeostasis; Humans; Immune response; Immunology; Inflammatory diseases; Keratinocytes - metabolism; Life Sciences; Recovery of function; Skin diseases; Transcription Factors - genetics; Transcription Factors - metabolism; Tumor Suppressor Proteins

Atopic dermatitis (AD) is a common chronic inflammatory skin disorder characterized by disrupted epidermal barrier function and aberrant immune responses. Despite recent developments in new therapeutics for AD, there is still a large unmet medical need for disease management due to the complex and m...