Prenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans

• Published in: Scientific reports Vol. 14; no. 1; pp. 1946 - 10
• Main Authors: Viola, Thiago Wendt, Danzer, Christina, Mardini, Victor, Szobot, Claudia, Chrusciel, João Henrique, Stertz, Laura, Schmitz, Joy M., Walss-Bass, Consuelo, Fries, Gabriel R., Grassi-Oliveira, Rodrigo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208/177; 692/499; Autism; Autistic Disorder; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Child; Cocaine; Cocaine - toxicity; Cord blood; Diabetes; Diabetes Mellitus; DNA methylation; Epigenesis, Genetic; Epigenetics; Female; Genomes; Health problems; Humanities and Social Sciences; Humans; Infant, Newborn; Mental disorders; multidisciplinary; Neonates; Offspring; Pediatrics; Phenotypes; Pregnancy; Prenatal experience; Psychosis; Science; Science (multidisciplinary); Synapses; Tobacco smoking; Umbilical cord; γ-Aminobutyric acid

The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in humans. We profiled genome-wide DNA methylation (DNAm) of umbilical cord blood (UCB) from newborns with (n = 35) and without (n = 47) PCE. We...