Prenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans

The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in humans. We profiled genome-wide DNA methylation (DNAm) of umbilical cord blood (UCB) from newborns with (n = 35) and without (n = 47) PCE. We...

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Published inScientific reports Vol. 14; no. 1; pp. 1946 - 10
Main Authors Viola, Thiago Wendt, Danzer, Christina, Mardini, Victor, Szobot, Claudia, Chrusciel, João Henrique, Stertz, Laura, Schmitz, Joy M., Walss-Bass, Consuelo, Fries, Gabriel R., Grassi-Oliveira, Rodrigo
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 23.01.2024
Nature Publishing Group
Nature Portfolio
Subjects
631/208/177
692/499
Autism
Autistic Disorder
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Child
Cocaine
Cocaine - toxicity
Cord blood
Diabetes
Diabetes Mellitus
DNA methylation
Epigenesis, Genetic
Epigenetics
Female
Genomes
Health problems
Humanities and Social Sciences
Humans
Infant, Newborn
Mental disorders
multidisciplinary
Neonates
Offspring
Pediatrics
Phenotypes
Pregnancy
Prenatal experience
Psychosis
Science
Science (multidisciplinary)
Synapses
Tobacco smoking
Umbilical cord
γ-Aminobutyric acid
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Abstract The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in humans. We profiled genome-wide DNA methylation (DNAm) of umbilical cord blood (UCB) from newborns with (n = 35) and without (n = 47) PCE. We used DNAm data to (1) assess pediatric epigenetic clocks at birth and (2) to estimate epigenetic scores (ES) for lifetime disorders. We generated gestational epigenetic age estimates (DNAmGA) based on Knight and Bohlin epigenetic clocks. We also investigated the association between DNAmGA and UCB serum brain-derived neurotrophic factor (BDNF) levels. Considering the large-scale DNAm data availability and existing evidence regarding PCE as a risk for health problems later in life, we generated ES for tobacco smoking, psychosis, autism, diabetes, and obesity. A gene ontology (GO) analysis on the CpGs included in the ES with group differences was performed. PCE was associated with lower DNAmGA in newborns, and this effect remained significant when controlling for potential confounders, such as blood cell type composition predicted by DNAm and obstetric data. DNAmGA was negatively correlated with BDNF levels in the serum of UCB. Higher tobacco smoking, psychosis, and diabetes ES were found in the PCE group. The GO analysis revealed GABAergic synapses as a potential pathway altered by PCE. Our findings of decelerated DNAmGA and ES for adverse phenotypes associated with PCE, suggest that the effects of gestational cocaine exposure on the epigenetic landscape of human newborns are detectable at birth.
AbstractList The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in humans. We profiled genome-wide DNA methylation (DNAm) of umbilical cord blood (UCB) from newborns with (n = 35) and without (n = 47) PCE. We used DNAm data to (1) assess pediatric epigenetic clocks at birth and (2) to estimate epigenetic scores (ES) for lifetime disorders. We generated gestational epigenetic age estimates (DNAmGA) based on Knight and Bohlin epigenetic clocks. We also investigated the association between DNAmGA and UCB serum brain-derived neurotrophic factor (BDNF) levels. Considering the large-scale DNAm data availability and existing evidence regarding PCE as a risk for health problems later in life, we generated ES for tobacco smoking, psychosis, autism, diabetes, and obesity. A gene ontology (GO) analysis on the CpGs included in the ES with group differences was performed. PCE was associated with lower DNAmGA in newborns, and this effect remained significant when controlling for potential confounders, such as blood cell type composition predicted by DNAm and obstetric data. DNAmGA was negatively correlated with BDNF levels in the serum of UCB. Higher tobacco smoking, psychosis, and diabetes ES were found in the PCE group. The GO analysis revealed GABAergic synapses as a potential pathway altered by PCE. Our findings of decelerated DNAmGA and ES for adverse phenotypes associated with PCE, suggest that the effects of gestational cocaine exposure on the epigenetic landscape of human newborns are detectable at birth.The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in humans. We profiled genome-wide DNA methylation (DNAm) of umbilical cord blood (UCB) from newborns with (n = 35) and without (n = 47) PCE. We used DNAm data to (1) assess pediatric epigenetic clocks at birth and (2) to estimate epigenetic scores (ES) for lifetime disorders. We generated gestational epigenetic age estimates (DNAmGA) based on Knight and Bohlin epigenetic clocks. We also investigated the association between DNAmGA and UCB serum brain-derived neurotrophic factor (BDNF) levels. Considering the large-scale DNAm data availability and existing evidence regarding PCE as a risk for health problems later in life, we generated ES for tobacco smoking, psychosis, autism, diabetes, and obesity. A gene ontology (GO) analysis on the CpGs included in the ES with group differences was performed. PCE was associated with lower DNAmGA in newborns, and this effect remained significant when controlling for potential confounders, such as blood cell type composition predicted by DNAm and obstetric data. DNAmGA was negatively correlated with BDNF levels in the serum of UCB. Higher tobacco smoking, psychosis, and diabetes ES were found in the PCE group. The GO analysis revealed GABAergic synapses as a potential pathway altered by PCE. Our findings of decelerated DNAmGA and ES for adverse phenotypes associated with PCE, suggest that the effects of gestational cocaine exposure on the epigenetic landscape of human newborns are detectable at birth.
The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in humans. We profiled genome-wide DNA methylation (DNAm) of umbilical cord blood (UCB) from newborns with (n = 35) and without (n = 47) PCE. We used DNAm data to (1) assess pediatric epigenetic clocks at birth and (2) to estimate epigenetic scores (ES) for lifetime disorders. We generated gestational epigenetic age estimates (DNAmGA) based on Knight and Bohlin epigenetic clocks. We also investigated the association between DNAmGA and UCB serum brain-derived neurotrophic factor (BDNF) levels. Considering the large-scale DNAm data availability and existing evidence regarding PCE as a risk for health problems later in life, we generated ES for tobacco smoking, psychosis, autism, diabetes, and obesity. A gene ontology (GO) analysis on the CpGs included in the ES with group differences was performed. PCE was associated with lower DNAmGA in newborns, and this effect remained significant when controlling for potential confounders, such as blood cell type composition predicted by DNAm and obstetric data. DNAmGA was negatively correlated with BDNF levels in the serum of UCB. Higher tobacco smoking, psychosis, and diabetes ES were found in the PCE group. The GO analysis revealed GABAergic synapses as a potential pathway altered by PCE. Our findings of decelerated DNAmGA and ES for adverse phenotypes associated with PCE, suggest that the effects of gestational cocaine exposure on the epigenetic landscape of human newborns are detectable at birth.
Abstract The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in humans. We profiled genome-wide DNA methylation (DNAm) of umbilical cord blood (UCB) from newborns with (n = 35) and without (n = 47) PCE. We used DNAm data to (1) assess pediatric epigenetic clocks at birth and (2) to estimate epigenetic scores (ES) for lifetime disorders. We generated gestational epigenetic age estimates (DNAmGA) based on Knight and Bohlin epigenetic clocks. We also investigated the association between DNAmGA and UCB serum brain-derived neurotrophic factor (BDNF) levels. Considering the large-scale DNAm data availability and existing evidence regarding PCE as a risk for health problems later in life, we generated ES for tobacco smoking, psychosis, autism, diabetes, and obesity. A gene ontology (GO) analysis on the CpGs included in the ES with group differences was performed. PCE was associated with lower DNAmGA in newborns, and this effect remained significant when controlling for potential confounders, such as blood cell type composition predicted by DNAm and obstetric data. DNAmGA was negatively correlated with BDNF levels in the serum of UCB. Higher tobacco smoking, psychosis, and diabetes ES were found in the PCE group. The GO analysis revealed GABAergic synapses as a potential pathway altered by PCE. Our findings of decelerated DNAmGA and ES for adverse phenotypes associated with PCE, suggest that the effects of gestational cocaine exposure on the epigenetic landscape of human newborns are detectable at birth.
ArticleNumber 1946
Author Chrusciel, João Henrique
Fries, Gabriel R.
Stertz, Laura
Szobot, Claudia
Schmitz, Joy M.
Grassi-Oliveira, Rodrigo
Danzer, Christina
Mardini, Victor
Walss-Bass, Consuelo
Viola, Thiago Wendt
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Cites_doi 10.1186/s13059-016-1063-4
10.1038/sj.jp.7210552
10.1007/s11892-015-0624-3
10.1016/j.jocn.2020.02.013
10.1016/j.reprotox.2015.05.007
10.1001/archpsyc.63.9.1009
10.1523/JNEUROSCI.1984-09.2009
10.3389/fgene.2019.00770
10.1016/j.drugalcdep.2022.109736
10.1186/s13148-021-01055-z
10.1503/jpn.130027
10.1016/j.biopsych.2023.02.001
10.1016/j.jpsychires.2015.03.018
10.1016/j.biopsych.2023.07.010
10.1016/j.drugalcdep.2017.06.025
10.1007/978-3-319-24277-4
10.1186/s13059-016-1068-z
10.1186/gb-2013-14-10-r115
10.1192/bjp.bp.108.062471
10.1542/peds.2012-0945
10.1161/CIRCGENETICS.116.001506
10.1590/2237-6089-2015-0081
10.1095/biolreprod.108.072983
10.1007/s00404-018-4833-2
10.1038/s41574-018-0097-y
10.1097/CM9.0000000000001723
10.1016/j.ntt.2010.11.002
10.1016/j.biopsych.2019.03.534
10.7554/eLife.58430
10.3389/fneur.2021.643576
10.1186/1868-7083-6-4
10.1080/15592294.2017.1363951
10.1186/s13148-023-01480-2
10.1371/journal.pone.0001919
10.1038/s41596-020-0353-1
10.1007/s00125-022-05652-2
10.1093/bioinformatics/btu049
10.1001/jamapsychiatry.2020.2902
10.1016/j.drugalcdep.2012.10.004
10.1093/bioinformatics/btaa825
10.1038/s41525-022-00320-1
10.1080/15592294.2019.1644879
10.1046/j.1360-0443.2002.00185.x
10.1001/jamanetworkopen.2022.48055
10.1590/1516-4446-2016-2035
10.1136/archdischild-2021-323260
10.1016/S0022-3476(78)80621-0
10.1186/s13229-018-0224-6
10.1038/s41380-021-01297-6
10.1016/j.pedneo.2020.12.012
10.1016/j.ntt.2004.02.004
10.1080/15592294.2022.2102846
10.1002/syn.20814
10.2217/epi-2016-0153
10.1093/eep/dvz022
10.1186/s13059-019-1664-9
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References Elliott, Tillin, McArdle, Ho, Duggirala, Frayling (CR58) 2014; 6
Rauschert, Melton, Burdge, Craig, Godfrey, Holbrook (CR15) 2019; 10
Bohlin, Håberg, Magnus, Reese, Gjessing, Magnus (CR26) 2016; 17
Daredia, Huen, Van Der Laan, Collender, Nwanaji-Enwerem, Harley (CR27) 2022; 17
Aryee, Jaffe, Corrada-Bravo, Ladd-Acosta, Feinberg, Hansen (CR52) 2014; 30
Tanrıverdi, Kultursay, Tekgul, Sozmen, AltunKoroglu, Aktan (CR14) 2020; 74
Abé, Mon, Durazzo, Pennington, Schmidt, Meyerhoff (CR41) 2013; 130
Buckingham-Howes, Berger, Scaletti, Black (CR1) 2013; 131
Dos Santos, de MeloBastosCavalcante, Barbosa, Gitai, Duzzioni, Tilelli (CR2) 2018; 298
Bozack, Rifas-Shiman, Gold, Laubach, Perng, Hivert (CR45) 2023; 15
Fraszczyk, Spijkerman, Zhang, Brandmaier, Day, Zhou (CR19) 2022; 65
Nakahara, Tsugawa, Noda, Ueno, Honda, Kinjo (CR43) 2022; 27
Andrews, Sheppard, Windham, Schieve, Schendel, Croen (CR17) 2018; 9
Zammit, Thomas, Thompson, Horwood, Menezes, Gunnell (CR38) 2009; 195
Knight, Craig, Theda, Bækvad-Hansen, Bybjerg-Grauholm, Hansen (CR25) 2016; 17
Wickham (CR59) 2016
Mardini, Rohde, Ceresér, CeM, da Silva, Xavier (CR46) 2016; 38
(CR48) 2002; 97
Pelegí-Sisó, de Prado, Ronkainen, Bustamante, González (CR53) 2021; 37
Teschendorff, Zheng (CR54) 2017; 9
Young-Wolff, Slama, Sarovar, Terplan, Ansley, Adams (CR7) 2022; 5
Sheehan, Lecrubier, Sheehan, Amorim, Janavs, Weiller (CR47) 1998; 59
Lu, Lim, Poo (CR40) 2009; 29
Sayols-Baixeras, Subirana, Fernández-Sanlés, Sentí, Lluís-Ganella, Marrugat (CR55) 2017; 12
Wang, Zhou (CR28) 2021; 134
Makarious, Teng, Oei (CR3) 2022; 107
Paul, Hatoum, Fine, Johnson, Hansen, Karcher (CR37) 2021; 78
Haftorn, Lee, Denault, Page, Nustad, Lyle (CR9) 2021; 13
Rubio-Abadal, Ochoa, Barajas, Baños, Dolz, Sanchez (CR21) 2015; 65
Vaiserman (CR23) 2015; 15
Mardini, Rohde, Ceresér, Gubert, Silva, Xavier (CR33) 2017; 39
Min, Minnes, Kim, Kim, Singer (CR20) 2023; 242
Hannon, Dempster, Mansell, Burrage, Bass, Bohlken (CR18) 2021; 10
Novikova, He, Bai, Cutrufello, Lidow, Undieh (CR6) 2008; 3
CR50
Schulte, Kaag, Wiers, Schmaal, van den Brink, Reneman (CR42) 2017; 179
Joehanes, Just, Marioni, Pilling, Reynolds, Mandaviya (CR16) 2016; 9
Horvath (CR32) 2013; 14
Müller, Scherer, Assenov, Lutsik, Walter, Lengauer (CR51) 2019; 20
Krey, Stocchero, Creutzberg, Heberle, Tractenberg, Xiang (CR11) 2021; 12
Hüls, Czamara (CR35) 2020; 15
Ornoy, Weinstein-Fudim, Ergaz (CR22) 2015; 56
Alati, Al Mamun, Williams, O'Callaghan, Najman, Bor (CR36) 2006; 63
Thompson, Hill, Rakocz, Chiang, Geschwind, Sankararaman (CR8) 2022; 7
Viola, Tractenberg, Levandowski, Pezzi, Bauer, Teixeira (CR34) 2014; 39
Hand, Noble, McVeigh, Kim, Yoon (CR29) 2001; 21
Zhang, Meyer, Zhang (CR30) 2009; 80
Walss-Bass, Fries, Viola, Sanvicente-Vieira, Schmitz, Rovaris (CR31) 2019; 85
Kadioglu, Sert, TopfedaisiOzkan, Celen (CR12) 2023; 15
Lee, Chen, Worden, Freed (CR39) 2011; 65
Kiltschewskij, Reay, Geaghan, Atkins, Xavier, Zhang (CR57) 2023
Capurro, Konichezky, Fonseca, Caldeyro-Barcia (CR49) 1978; 93
Harvanek, Boks, Vinkers, Higgins-Chen (CR10) 2023; 94
Su, Liu, Chen, Ou-Yang, Huang, Tsai (CR13) 2021; 62
Choi, Mak, O'Reilly (CR56) 2020; 15
LaGasse, Gaskins, Bada, Shankaran, Liu, Lester (CR24) 2011; 33
Gromada, Chabosseau, Rutter (CR44) 2018; 14
Wanner, Colwell, Faulk (CR4) 2019; 5
Church, Holmes, Tilak, Hotra (CR5) 2004; 26
TW Viola (52433_CR34) 2014; 39
R Joehanes (52433_CR16) 2016; 9
SE Paul (52433_CR37) 2021; 78
NM Wanner (52433_CR4) 2019; 5
SV Andrews (52433_CR17) 2018; 9
DJ Kiltschewskij (52433_CR57) 2023
L Makarious (52433_CR3) 2022; 107
HR Elliott (52433_CR58) 2014; 6
ZM Harvanek (52433_CR10) 2023; 94
LL LaGasse (52433_CR24) 2011; 33
SW Choi (52433_CR56) 2020; 15
E Hannon (52433_CR18) 2021; 10
H Capurro (52433_CR49) 1978; 93
V Mardini (52433_CR46) 2016; 38
S Horvath (52433_CR32) 2013; 14
M Tanrıverdi (52433_CR14) 2020; 74
MJ Aryee (52433_CR52) 2014; 30
FC Krey (52433_CR11) 2021; 12
CH Su (52433_CR13) 2021; 62
N Kadioglu (52433_CR12) 2023; 15
S Rauschert (52433_CR15) 2019; 10
M Thompson (52433_CR8) 2022; 7
AK Knight (52433_CR25) 2016; 17
C Walss-Bass (52433_CR31) 2019; 85
F Müller (52433_CR51) 2019; 20
WHO ASSIST Working Group (52433_CR48) 2002; 97
H Wickham (52433_CR59) 2016
R Alati (52433_CR36) 2006; 63
SI Novikova (52433_CR6) 2008; 3
C Abé (52433_CR41) 2013; 130
AM Vaiserman (52433_CR23) 2015; 15
D Pelegí-Sisó (52433_CR53) 2021; 37
52433_CR50
AK Bozack (52433_CR45) 2023; 15
MHJ Schulte (52433_CR42) 2017; 179
KC Young-Wolff (52433_CR7) 2022; 5
A Hüls (52433_CR35) 2020; 15
V Mardini (52433_CR33) 2017; 39
J Wang (52433_CR28) 2021; 134
MO Min (52433_CR20) 2023; 242
E Fraszczyk (52433_CR19) 2022; 65
AE Teschendorff (52433_CR54) 2017; 9
MW Church (52433_CR5) 2004; 26
I Hand (52433_CR29) 2001; 21
H Zhang (52433_CR30) 2009; 80
S Zammit (52433_CR38) 2009; 195
DV Sheehan (52433_CR47) 1998; 59
JF Dos Santos (52433_CR2) 2018; 298
E Rubio-Abadal (52433_CR21) 2015; 65
KL Haftorn (52433_CR9) 2021; 13
J Gromada (52433_CR44) 2018; 14
J Bohlin (52433_CR26) 2016; 17
S Sayols-Baixeras (52433_CR55) 2017; 12
S Daredia (52433_CR27) 2022; 17
CT Lee (52433_CR39) 2011; 65
H Lu (52433_CR40) 2009; 29
T Nakahara (52433_CR43) 2022; 27
S Buckingham-Howes (52433_CR1) 2013; 131
A Ornoy (52433_CR22) 2015; 56
References_xml – volume: 17
  start-page: 207
  issue: 1
  year: 2016
  ident: CR26
  article-title: Prediction of gestational age based on genome-wide differentially methylated regions
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1063-4
  contributor:
    fullname: Magnus
– volume: 21
  start-page: 372
  year: 2001
  end-page: 375
  ident: CR29
  article-title: The effects of intrauterine cocaine exposure on the respiratory status of the very low birht weight infant
  publication-title: J. Perinatol.
  doi: 10.1038/sj.jp.7210552
  contributor:
    fullname: Yoon
– volume: 15
  start-page: 48
  issue: 8
  year: 2015
  ident: CR23
  article-title: Early-life exposure to substance abuse and risk of type 2 diabetes in adulthood
  publication-title: Curr. Diab. Rep.
  doi: 10.1007/s11892-015-0624-3
  contributor:
    fullname: Vaiserman
– volume: 74
  start-page: 168
  year: 2020
  end-page: 174
  ident: CR14
  article-title: Clinical value of a set of neuropeptides in term and preterm neonates with seizures: Brain derived neurotrophic factor, galanin and neuropeptide Y
  publication-title: J. Clin. Neurosci.
  doi: 10.1016/j.jocn.2020.02.013
  contributor:
    fullname: Aktan
– volume: 56
  start-page: 155
  year: 2015
  end-page: 169
  ident: CR22
  article-title: Prenatal factors associated with autism spectrum disorder (ASD)
  publication-title: Reprod. Toxicol.
  doi: 10.1016/j.reprotox.2015.05.007
  contributor:
    fullname: Ergaz
– volume: 63
  start-page: 1009
  issue: 9
  year: 2006
  end-page: 1016
  ident: CR36
  article-title: In utero alcohol exposure and prediction of alcohol disorders in early adulthood: A birth cohort study
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.63.9.1009
  contributor:
    fullname: Bor
– volume: 29
  start-page: 12664
  issue: 40
  year: 2009
  end-page: 12674
  ident: CR40
  article-title: Cocaine exposure in utero alters synaptic plasticity in the medial prefrontal cortex of postnatal rats
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1984-09.2009
  contributor:
    fullname: Poo
– volume: 10
  start-page: 770
  year: 2019
  ident: CR15
  article-title: Maternal smoking during pregnancy induces persistent epigenetic changes into adolescence, independent of postnatal smoke exposure and is associated with cardiometabolic risk
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2019.00770
  contributor:
    fullname: Holbrook
– volume: 59
  start-page: 22
  issue: 20
  year: 1998
  end-page: 33
  ident: CR47
  article-title: The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10
  publication-title: J. Clin. Psychiatry
  contributor:
    fullname: Weiller
– volume: 242
  start-page: 109736
  year: 2023
  ident: CR20
  article-title: Prenatal cocaine exposure and substance use disorder in emerging adulthood at age 21
  publication-title: Drug Alcohol Depend.
  doi: 10.1016/j.drugalcdep.2022.109736
  contributor:
    fullname: Singer
– volume: 13
  start-page: 82
  issue: 1
  year: 2021
  ident: CR9
  article-title: An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies
  publication-title: Clin. Epigenet.
  doi: 10.1186/s13148-021-01055-z
  contributor:
    fullname: Lyle
– volume: 39
  start-page: 206
  issue: 3
  year: 2014
  end-page: 214
  ident: CR34
  article-title: Neurotrophic factors in women with crack cocaine dependence during early abstinence: The role of early life stress
  publication-title: J. Psychiatry Neurosci.
  doi: 10.1503/jpn.130027
  contributor:
    fullname: Teixeira
– volume: 94
  start-page: 694
  issue: 9
  year: 2023
  end-page: 705
  ident: CR10
  article-title: The cutting edge of epigenetic clocks: In search of mechanisms linking aging and mental health
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2023.02.001
  contributor:
    fullname: Higgins-Chen
– volume: 65
  start-page: 108
  year: 2015
  end-page: 114
  ident: CR21
  article-title: Birth weight and obstetric complications determine age at onset in first episode of psychosis
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2015.03.018
  contributor:
    fullname: Sanchez
– year: 2023
  ident: CR57
  article-title: Alteration of DNA methylation and epigenetic scores associated with features of schizophrenia and common variant genetic risk
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2023.07.010
  contributor:
    fullname: Zhang
– volume: 179
  start-page: 117
  year: 2017
  end-page: 123
  ident: CR42
  article-title: Prefrontal Glx and GABA concentrations and impulsivity in cigarette smokers and smoking polysubstance users
  publication-title: Drug Alcohol Depend.
  doi: 10.1016/j.drugalcdep.2017.06.025
  contributor:
    fullname: Reneman
– year: 2016
  ident: CR59
  publication-title: ggplot2: Elegant Graphics for Data Analysis
  doi: 10.1007/978-3-319-24277-4
  contributor:
    fullname: Wickham
– volume: 17
  start-page: 206
  issue: 1
  year: 2016
  ident: CR25
  article-title: An epigenetic clock for gestational age at birth based on blood methylation data
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1068-z
  contributor:
    fullname: Hansen
– volume: 14
  start-page: R115
  issue: 10
  year: 2013
  ident: CR32
  article-title: DNA methylation age of human tissues and cell types
  publication-title: Genome Biol.
  doi: 10.1186/gb-2013-14-10-r115
  contributor:
    fullname: Horvath
– volume: 195
  start-page: 294
  issue: 4
  year: 2009
  end-page: 300
  ident: CR38
  article-title: Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.bp.108.062471
  contributor:
    fullname: Gunnell
– volume: 131
  start-page: e1917
  issue: 6
  year: 2013
  end-page: e1936
  ident: CR1
  article-title: Systematic review of prenatal cocaine exposure and adolescent development
  publication-title: Pediatrics
  doi: 10.1542/peds.2012-0945
  contributor:
    fullname: Black
– volume: 9
  start-page: 436
  issue: 5
  year: 2016
  end-page: 447
  ident: CR16
  article-title: Epigenetic signatures of cigarette smoking
  publication-title: Circ. Cardiovasc. Genet.
  doi: 10.1161/CIRCGENETICS.116.001506
  contributor:
    fullname: Mandaviya
– volume: 38
  start-page: 40
  issue: 1
  year: 2016
  end-page: 9
  ident: CR46
  article-title: IL-6 and IL-10 levels in the umbilical cord blood of newborns with a history of crack/cocaine exposure in utero: A comparative study
  publication-title: Trends Psychiatry Psychother.
  doi: 10.1590/2237-6089-2015-0081
  contributor:
    fullname: Xavier
– volume: 80
  start-page: 440
  issue: 3
  year: 2009
  end-page: 448
  ident: CR30
  article-title: Fetal exposure to cocaine causes programming of Prkce gene repression in the left ventricle of adult rat offspring
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod.108.072983
  contributor:
    fullname: Zhang
– ident: CR50
– volume: 298
  start-page: 487
  issue: 3
  year: 2018
  end-page: 503
  ident: CR2
  article-title: Maternal, fetal and neonatal consequences associated with the use of crack cocaine during the gestational period: A systematic review and meta-analysis
  publication-title: Arch. Gynecol. Obstet.
  doi: 10.1007/s00404-018-4833-2
  contributor:
    fullname: Tilelli
– volume: 14
  start-page: 694
  issue: 12
  year: 2018
  end-page: 704
  ident: CR44
  article-title: The α-cell in diabetes mellitus
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/s41574-018-0097-y
  contributor:
    fullname: Rutter
– volume: 134
  start-page: 2901
  issue: 24
  year: 2021
  end-page: 2910
  ident: CR28
  article-title: Epigenetic clocks in the pediatric population: When and why they tick?
  publication-title: Chin. Med. J. (Engl.)
  doi: 10.1097/CM9.0000000000001723
  contributor:
    fullname: Zhou
– volume: 33
  start-page: 188
  issue: 2
  year: 2011
  end-page: 197
  ident: CR24
  article-title: Prenatal cocaine exposure and childhood obesity at nine years
  publication-title: Neurotoxicol. Teratol.
  doi: 10.1016/j.ntt.2010.11.002
  contributor:
    fullname: Lester
– volume: 85
  start-page: S211
  year: 2019
  ident: CR31
  article-title: Epigenetics of cocaine use disorder: A collaborative case-control initiave in blood and brain
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2019.03.534
  contributor:
    fullname: Rovaris
– volume: 10
  start-page: e58430
  year: 2021
  ident: CR18
  article-title: DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
  publication-title: Elife
  doi: 10.7554/eLife.58430
  contributor:
    fullname: Bohlken
– volume: 12
  start-page: 643576
  year: 2021
  ident: CR11
  article-title: Neurotrophic factor levels in preterm infants: A systematic review and meta-analysis
  publication-title: Front. Neurol.
  doi: 10.3389/fneur.2021.643576
  contributor:
    fullname: Xiang
– volume: 6
  start-page: 4
  issue: 1
  year: 2014
  ident: CR58
  article-title: Differences in smoking associated DNA methylation patterns in South Asians and Europeans
  publication-title: Clin. Epigenet.
  doi: 10.1186/1868-7083-6-4
  contributor:
    fullname: Frayling
– volume: 12
  start-page: 909
  issue: 10
  year: 2017
  end-page: 916
  ident: CR55
  article-title: DNA methylation and obesity traits: An epigenome-wide association study. The REGICOR study
  publication-title: Epigenetics
  doi: 10.1080/15592294.2017.1363951
  contributor:
    fullname: Marrugat
– volume: 15
  start-page: 62
  issue: 1
  year: 2023
  ident: CR45
  article-title: DNA methylation age at birth and childhood: Performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort
  publication-title: Clin. Epigenet.
  doi: 10.1186/s13148-023-01480-2
  contributor:
    fullname: Hivert
– volume: 3
  start-page: e1919
  issue: 4
  year: 2008
  ident: CR6
  article-title: Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0001919
  contributor:
    fullname: Undieh
– volume: 15
  start-page: 2759
  issue: 9
  year: 2020
  end-page: 2772
  ident: CR56
  article-title: Tutorial: A guide to performing polygenic risk score analyses
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-020-0353-1
  contributor:
    fullname: O'Reilly
– volume: 65
  start-page: 763
  issue: 5
  year: 2022
  end-page: 776
  ident: CR19
  article-title: Epigenome-wide association study of incident type 2 diabetes: A meta-analysis of five prospective European cohorts
  publication-title: Diabetologia
  doi: 10.1007/s00125-022-05652-2
  contributor:
    fullname: Zhou
– volume: 30
  start-page: 1363
  issue: 10
  year: 2014
  end-page: 1369
  ident: CR52
  article-title: Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu049
  contributor:
    fullname: Hansen
– volume: 15
  start-page: e43354
  issue: 8
  year: 2023
  ident: CR12
  article-title: Clinical importance of serum BDNF (brain-derived neurotrophic factor) level for the management of pregnancies complicated with meconium-stained amniotic fluid
  publication-title: Cureus
  contributor:
    fullname: Celen
– volume: 78
  start-page: 64
  issue: 1
  year: 2021
  end-page: 76
  ident: CR37
  article-title: Associations between prenatal cannabis exposure and childhood outcomes: Results from the ABCD study
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2020.2902
  contributor:
    fullname: Karcher
– volume: 130
  start-page: 30
  issue: 1–3
  year: 2013
  end-page: 37
  ident: CR41
  article-title: Polysubstance and alcohol dependence: Unique abnormalities of magnetic resonance-derived brain metabolite levels
  publication-title: Drug Alcohol Depend.
  doi: 10.1016/j.drugalcdep.2012.10.004
  contributor:
    fullname: Meyerhoff
– volume: 37
  start-page: 1759
  issue: 12
  year: 2021
  end-page: 1760
  ident: CR53
  article-title: methylclock: A Bioconductor package to estimate DNA methylation age
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btaa825
  contributor:
    fullname: González
– volume: 7
  start-page: 50
  issue: 1
  year: 2022
  ident: CR8
  article-title: Methylation risk scores are associated with a collection of phenotypes within electronic health record systems
  publication-title: NPJ Genomic Med.
  doi: 10.1038/s41525-022-00320-1
  contributor:
    fullname: Sankararaman
– volume: 15
  start-page: 1
  issue: 1–2
  year: 2020
  end-page: 11
  ident: CR35
  article-title: Methodological challenges in constructing DNA methylation risk scores
  publication-title: Epigenetics
  doi: 10.1080/15592294.2019.1644879
  contributor:
    fullname: Czamara
– volume: 97
  start-page: 1183
  issue: 9
  year: 2002
  end-page: 1194
  ident: CR48
  article-title: The alcohol, smoking and substance involvement screening test (ASSIST): Development, reliability and feasibility
  publication-title: Addiction
  doi: 10.1046/j.1360-0443.2002.00185.x
– volume: 5
  start-page: e2248055
  issue: 12
  year: 2022
  ident: CR7
  article-title: Trends in self-reported and biochemically verified cocaine and methamphetamine use among pregnant individuals in Northern California, 2011–2019
  publication-title: JAMA Netw. Open
  doi: 10.1001/jamanetworkopen.2022.48055
  contributor:
    fullname: Adams
– volume: 39
  start-page: 263
  issue: 3
  year: 2017
  end-page: 266
  ident: CR33
  article-title: TBARS and BDNF levels in newborns exposed to crack/cocaine during pregnancy: A comparative study
  publication-title: Braz. J. Psychiatry
  doi: 10.1590/1516-4446-2016-2035
  contributor:
    fullname: Xavier
– volume: 107
  start-page: 617
  issue: 6
  year: 2022
  end-page: 623
  ident: CR3
  article-title: SIDS is associated with prenatal drug use: A meta-analysis and systematic review of 4 238 685 infants
  publication-title: Arch. Dis. Child Fetal Neonatal Ed.
  doi: 10.1136/archdischild-2021-323260
  contributor:
    fullname: Oei
– volume: 93
  start-page: 120
  issue: 1
  year: 1978
  end-page: 122
  ident: CR49
  article-title: A simplified method for diagnosis of gestational age in the newborn infant
  publication-title: J. Pediatr.
  doi: 10.1016/S0022-3476(78)80621-0
  contributor:
    fullname: Caldeyro-Barcia
– volume: 9
  start-page: 40
  year: 2018
  ident: CR17
  article-title: Case-control meta-analysis of blood DNA methylation and autism spectrum disorder
  publication-title: Mol. Autism
  doi: 10.1186/s13229-018-0224-6
  contributor:
    fullname: Croen
– volume: 27
  start-page: 744
  issue: 1
  year: 2022
  end-page: 757
  ident: CR43
  article-title: Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: A meta-analysis of 1 -magnetic resonance spectroscopy studies
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-021-01297-6
  contributor:
    fullname: Kinjo
– volume: 62
  start-page: 298
  issue: 3
  year: 2021
  end-page: 304
  ident: CR13
  article-title: Correlations between serum BDNF levels and neurodevelopmental outcomes in infants of mothers with gestational diabetes
  publication-title: Pediatr. Neonatol.
  doi: 10.1016/j.pedneo.2020.12.012
  contributor:
    fullname: Tsai
– volume: 26
  start-page: 429
  issue: 3
  year: 2004
  end-page: 441
  ident: CR5
  article-title: Prenatal cocaine exposure influences the growth and life span of laboratory rats
  publication-title: Neurotoxicol. Teratol.
  doi: 10.1016/j.ntt.2004.02.004
  contributor:
    fullname: Hotra
– volume: 17
  start-page: 2006
  issue: 13
  year: 2022
  end-page: 2021
  ident: CR27
  article-title: Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort
  publication-title: Epigenetics
  doi: 10.1080/15592294.2022.2102846
  contributor:
    fullname: Harley
– volume: 65
  start-page: 21
  issue: 1
  year: 2011
  end-page: 34
  ident: CR39
  article-title: Cocaine causes deficits in radial migration and alters the distribution of glutamate and GABA neurons in the developing rat cerebral cortex
  publication-title: Synapse
  doi: 10.1002/syn.20814
  contributor:
    fullname: Freed
– volume: 9
  start-page: 757
  issue: 5
  year: 2017
  end-page: 768
  ident: CR54
  article-title: Cell-type deconvolution in epigenome-wide association studies: A review and recommendations
  publication-title: Epigenomics
  doi: 10.2217/epi-2016-0153
  contributor:
    fullname: Zheng
– volume: 5
  start-page: dvz022
  issue: 4
  year: 2019
  ident: CR4
  article-title: The epigenetic legacy of illicit drugs: Developmental exposures and late-life phenotypes
  publication-title: Environ. Epigenet.
  doi: 10.1093/eep/dvz022
  contributor:
    fullname: Faulk
– volume: 20
  start-page: 55
  issue: 1
  year: 2019
  ident: CR51
  article-title: RnBeads 2.0: Comprehensive analysis of DNA methylation data
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1664-9
  contributor:
    fullname: Lengauer
– volume: 14
  start-page: R115
  issue: 10
  year: 2013
  ident: 52433_CR32
  publication-title: Genome Biol.
  doi: 10.1186/gb-2013-14-10-r115
  contributor:
    fullname: S Horvath
– volume: 27
  start-page: 744
  issue: 1
  year: 2022
  ident: 52433_CR43
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-021-01297-6
  contributor:
    fullname: T Nakahara
– year: 2023
  ident: 52433_CR57
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2023.07.010
  contributor:
    fullname: DJ Kiltschewskij
– volume: 97
  start-page: 1183
  issue: 9
  year: 2002
  ident: 52433_CR48
  publication-title: Addiction
  doi: 10.1046/j.1360-0443.2002.00185.x
  contributor:
    fullname: WHO ASSIST Working Group
– volume: 62
  start-page: 298
  issue: 3
  year: 2021
  ident: 52433_CR13
  publication-title: Pediatr. Neonatol.
  doi: 10.1016/j.pedneo.2020.12.012
  contributor:
    fullname: CH Su
– volume: 10
  start-page: 770
  year: 2019
  ident: 52433_CR15
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2019.00770
  contributor:
    fullname: S Rauschert
– volume: 63
  start-page: 1009
  issue: 9
  year: 2006
  ident: 52433_CR36
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.63.9.1009
  contributor:
    fullname: R Alati
– volume: 26
  start-page: 429
  issue: 3
  year: 2004
  ident: 52433_CR5
  publication-title: Neurotoxicol. Teratol.
  doi: 10.1016/j.ntt.2004.02.004
  contributor:
    fullname: MW Church
– volume: 15
  start-page: 62
  issue: 1
  year: 2023
  ident: 52433_CR45
  publication-title: Clin. Epigenet.
  doi: 10.1186/s13148-023-01480-2
  contributor:
    fullname: AK Bozack
– volume: 3
  start-page: e1919
  issue: 4
  year: 2008
  ident: 52433_CR6
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0001919
  contributor:
    fullname: SI Novikova
– volume: 15
  start-page: 2759
  issue: 9
  year: 2020
  ident: 52433_CR56
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-020-0353-1
  contributor:
    fullname: SW Choi
– volume: 15
  start-page: 1
  issue: 1–2
  year: 2020
  ident: 52433_CR35
  publication-title: Epigenetics
  doi: 10.1080/15592294.2019.1644879
  contributor:
    fullname: A Hüls
– volume: 5
  start-page: e2248055
  issue: 12
  year: 2022
  ident: 52433_CR7
  publication-title: JAMA Netw. Open
  doi: 10.1001/jamanetworkopen.2022.48055
  contributor:
    fullname: KC Young-Wolff
– volume: 33
  start-page: 188
  issue: 2
  year: 2011
  ident: 52433_CR24
  publication-title: Neurotoxicol. Teratol.
  doi: 10.1016/j.ntt.2010.11.002
  contributor:
    fullname: LL LaGasse
– volume: 130
  start-page: 30
  issue: 1–3
  year: 2013
  ident: 52433_CR41
  publication-title: Drug Alcohol Depend.
  doi: 10.1016/j.drugalcdep.2012.10.004
  contributor:
    fullname: C Abé
– volume: 65
  start-page: 763
  issue: 5
  year: 2022
  ident: 52433_CR19
  publication-title: Diabetologia
  doi: 10.1007/s00125-022-05652-2
  contributor:
    fullname: E Fraszczyk
– volume: 131
  start-page: e1917
  issue: 6
  year: 2013
  ident: 52433_CR1
  publication-title: Pediatrics
  doi: 10.1542/peds.2012-0945
  contributor:
    fullname: S Buckingham-Howes
– volume: 6
  start-page: 4
  issue: 1
  year: 2014
  ident: 52433_CR58
  publication-title: Clin. Epigenet.
  doi: 10.1186/1868-7083-6-4
  contributor:
    fullname: HR Elliott
– volume: 15
  start-page: 48
  issue: 8
  year: 2015
  ident: 52433_CR23
  publication-title: Curr. Diab. Rep.
  doi: 10.1007/s11892-015-0624-3
  contributor:
    fullname: AM Vaiserman
– volume: 39
  start-page: 263
  issue: 3
  year: 2017
  ident: 52433_CR33
  publication-title: Braz. J. Psychiatry
  doi: 10.1590/1516-4446-2016-2035
  contributor:
    fullname: V Mardini
– volume: 7
  start-page: 50
  issue: 1
  year: 2022
  ident: 52433_CR8
  publication-title: NPJ Genomic Med.
  doi: 10.1038/s41525-022-00320-1
  contributor:
    fullname: M Thompson
– volume: 56
  start-page: 155
  year: 2015
  ident: 52433_CR22
  publication-title: Reprod. Toxicol.
  doi: 10.1016/j.reprotox.2015.05.007
  contributor:
    fullname: A Ornoy
– volume: 93
  start-page: 120
  issue: 1
  year: 1978
  ident: 52433_CR49
  publication-title: J. Pediatr.
  doi: 10.1016/S0022-3476(78)80621-0
  contributor:
    fullname: H Capurro
– volume: 15
  start-page: e43354
  issue: 8
  year: 2023
  ident: 52433_CR12
  publication-title: Cureus
  contributor:
    fullname: N Kadioglu
– volume: 85
  start-page: S211
  year: 2019
  ident: 52433_CR31
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2019.03.534
  contributor:
    fullname: C Walss-Bass
– volume: 9
  start-page: 757
  issue: 5
  year: 2017
  ident: 52433_CR54
  publication-title: Epigenomics
  doi: 10.2217/epi-2016-0153
  contributor:
    fullname: AE Teschendorff
– volume: 5
  start-page: dvz022
  issue: 4
  year: 2019
  ident: 52433_CR4
  publication-title: Environ. Epigenet.
  doi: 10.1093/eep/dvz022
  contributor:
    fullname: NM Wanner
– ident: 52433_CR50
– volume: 9
  start-page: 40
  year: 2018
  ident: 52433_CR17
  publication-title: Mol. Autism
  doi: 10.1186/s13229-018-0224-6
  contributor:
    fullname: SV Andrews
– volume: 10
  start-page: e58430
  year: 2021
  ident: 52433_CR18
  publication-title: Elife
  doi: 10.7554/eLife.58430
  contributor:
    fullname: E Hannon
– volume: 80
  start-page: 440
  issue: 3
  year: 2009
  ident: 52433_CR30
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod.108.072983
  contributor:
    fullname: H Zhang
– volume: 12
  start-page: 909
  issue: 10
  year: 2017
  ident: 52433_CR55
  publication-title: Epigenetics
  doi: 10.1080/15592294.2017.1363951
  contributor:
    fullname: S Sayols-Baixeras
– volume: 17
  start-page: 206
  issue: 1
  year: 2016
  ident: 52433_CR25
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1068-z
  contributor:
    fullname: AK Knight
– volume: 74
  start-page: 168
  year: 2020
  ident: 52433_CR14
  publication-title: J. Clin. Neurosci.
  doi: 10.1016/j.jocn.2020.02.013
  contributor:
    fullname: M Tanrıverdi
– volume: 242
  start-page: 109736
  year: 2023
  ident: 52433_CR20
  publication-title: Drug Alcohol Depend.
  doi: 10.1016/j.drugalcdep.2022.109736
  contributor:
    fullname: MO Min
– volume: 65
  start-page: 108
  year: 2015
  ident: 52433_CR21
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/j.jpsychires.2015.03.018
  contributor:
    fullname: E Rubio-Abadal
– volume: 12
  start-page: 643576
  year: 2021
  ident: 52433_CR11
  publication-title: Front. Neurol.
  doi: 10.3389/fneur.2021.643576
  contributor:
    fullname: FC Krey
– volume: 29
  start-page: 12664
  issue: 40
  year: 2009
  ident: 52433_CR40
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1984-09.2009
  contributor:
    fullname: H Lu
– volume: 17
  start-page: 2006
  issue: 13
  year: 2022
  ident: 52433_CR27
  publication-title: Epigenetics
  doi: 10.1080/15592294.2022.2102846
  contributor:
    fullname: S Daredia
– volume: 298
  start-page: 487
  issue: 3
  year: 2018
  ident: 52433_CR2
  publication-title: Arch. Gynecol. Obstet.
  doi: 10.1007/s00404-018-4833-2
  contributor:
    fullname: JF Dos Santos
– volume: 65
  start-page: 21
  issue: 1
  year: 2011
  ident: 52433_CR39
  publication-title: Synapse
  doi: 10.1002/syn.20814
  contributor:
    fullname: CT Lee
– volume: 17
  start-page: 207
  issue: 1
  year: 2016
  ident: 52433_CR26
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1063-4
  contributor:
    fullname: J Bohlin
– volume: 78
  start-page: 64
  issue: 1
  year: 2021
  ident: 52433_CR37
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2020.2902
  contributor:
    fullname: SE Paul
– volume: 30
  start-page: 1363
  issue: 10
  year: 2014
  ident: 52433_CR52
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu049
  contributor:
    fullname: MJ Aryee
– volume: 39
  start-page: 206
  issue: 3
  year: 2014
  ident: 52433_CR34
  publication-title: J. Psychiatry Neurosci.
  doi: 10.1503/jpn.130027
  contributor:
    fullname: TW Viola
– volume: 13
  start-page: 82
  issue: 1
  year: 2021
  ident: 52433_CR9
  publication-title: Clin. Epigenet.
  doi: 10.1186/s13148-021-01055-z
  contributor:
    fullname: KL Haftorn
– volume: 134
  start-page: 2901
  issue: 24
  year: 2021
  ident: 52433_CR28
  publication-title: Chin. Med. J. (Engl.)
  doi: 10.1097/CM9.0000000000001723
  contributor:
    fullname: J Wang
– volume: 195
  start-page: 294
  issue: 4
  year: 2009
  ident: 52433_CR38
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.bp.108.062471
  contributor:
    fullname: S Zammit
– volume: 14
  start-page: 694
  issue: 12
  year: 2018
  ident: 52433_CR44
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/s41574-018-0097-y
  contributor:
    fullname: J Gromada
– volume: 107
  start-page: 617
  issue: 6
  year: 2022
  ident: 52433_CR3
  publication-title: Arch. Dis. Child Fetal Neonatal Ed.
  doi: 10.1136/archdischild-2021-323260
  contributor:
    fullname: L Makarious
– volume: 94
  start-page: 694
  issue: 9
  year: 2023
  ident: 52433_CR10
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2023.02.001
  contributor:
    fullname: ZM Harvanek
– volume-title: ggplot2: Elegant Graphics for Data Analysis
  year: 2016
  ident: 52433_CR59
  doi: 10.1007/978-3-319-24277-4
  contributor:
    fullname: H Wickham
– volume: 179
  start-page: 117
  year: 2017
  ident: 52433_CR42
  publication-title: Drug Alcohol Depend.
  doi: 10.1016/j.drugalcdep.2017.06.025
  contributor:
    fullname: MHJ Schulte
– volume: 20
  start-page: 55
  issue: 1
  year: 2019
  ident: 52433_CR51
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1664-9
  contributor:
    fullname: F Müller
– volume: 59
  start-page: 22
  issue: 20
  year: 1998
  ident: 52433_CR47
  publication-title: J. Clin. Psychiatry
  contributor:
    fullname: DV Sheehan
– volume: 37
  start-page: 1759
  issue: 12
  year: 2021
  ident: 52433_CR53
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btaa825
  contributor:
    fullname: D Pelegí-Sisó
– volume: 38
  start-page: 40
  issue: 1
  year: 2016
  ident: 52433_CR46
  publication-title: Trends Psychiatry Psychother.
  doi: 10.1590/2237-6089-2015-0081
  contributor:
    fullname: V Mardini
– volume: 9
  start-page: 436
  issue: 5
  year: 2016
  ident: 52433_CR16
  publication-title: Circ. Cardiovasc. Genet.
  doi: 10.1161/CIRCGENETICS.116.001506
  contributor:
    fullname: R Joehanes
– volume: 21
  start-page: 372
  year: 2001
  ident: 52433_CR29
  publication-title: J. Perinatol.
  doi: 10.1038/sj.jp.7210552
  contributor:
    fullname: I Hand
SSID ssj0000529419
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Snippet The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological outcomes in...
Abstract The investigation of the effects of prenatal cocaine exposure (PCE) on offspring has been inconsistent, with few studies investigating biological...
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proquest
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Open Access Repository
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StartPage 1946
SubjectTerms 631/208/177
692/499
Autism
Autistic Disorder
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Child
Cocaine
Cocaine - toxicity
Cord blood
Diabetes
Diabetes Mellitus
DNA methylation
Epigenesis, Genetic
Epigenetics
Female
Genomes
Health problems
Humanities and Social Sciences
Humans
Infant, Newborn
Mental disorders
multidisciplinary
Neonates
Offspring
Pediatrics
Phenotypes
Pregnancy
Prenatal experience
Psychosis
Science
Science (multidisciplinary)
Synapses
Tobacco smoking
Umbilical cord
γ-Aminobutyric acid
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Title Prenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans
URI https://link.springer.com/article/10.1038/s41598-024-52433-5
https://www.ncbi.nlm.nih.gov/pubmed/38253635
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https://www.proquest.com/docview/2917865228
https://pubmed.ncbi.nlm.nih.gov/PMC10803757
https://doaj.org/article/c7d1593095db41d287d401ecfeae2dc5
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