Decreased antioxidant-related superoxide dismutase 1 expression in peripheral immune cells indicates early ethanol exposure

• Published in: Scientific reports Vol. 14; no. 1; pp. 25091 - 15
• Main Authors: Kado, Akira, Moriya, Kyoji, Inoue, Yukiko, Yanagimoto, Shintaro, Tsutsumi, Takeya, Koike, Kazuhiko, Fujishiro, Mitsuhiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.10.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154/570; 631/208/199; 631/80/86/2366; 692/53/2423; 692/699/1503/1607/1608; Adult; Alcohol; Alcohol Drinking - adverse effects; Alcohol use; Alcohols; Antioxidant gene expression; Antioxidants; Antioxidants - metabolism; Early ethanol exposure; Ethanol; Gene expression; Humanities and Social Sciences; Humans; Leukocytes (mononuclear); Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Male; multidisciplinary; Oxidative stress; Oxidative Stress - drug effects; Peripheral blood mononuclear cells; Peripheral immune cells; Science; Science (multidisciplinary); SOD1; Superoxide dismutase; Superoxide Dismutase - blood; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Superoxide Dismutase-1 - genetics; Superoxide Dismutase-1 - metabolism; Young Adult; Young adults; Oxidative stress; Peripheral immune cells; Young adults; Antioxidant gene expression; Early ethanol exposure; SOD1

Alcohol consumption increases oxidative stress and imbalances in the antioxidant system, even with ethanol (EtOH) exposure at a young age. This study assessed changes in the antioxidant system following young EtOH exposure in peripheral immunity and measured sensitive indicators of heavy alcohol con...