Decreased antioxidant-related superoxide dismutase 1 expression in peripheral immune cells indicates early ethanol exposure

Alcohol consumption increases oxidative stress and imbalances in the antioxidant system, even with ethanol (EtOH) exposure at a young age. This study assessed changes in the antioxidant system following young EtOH exposure in peripheral immunity and measured sensitive indicators of heavy alcohol con...

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Published inScientific reports Vol. 14; no. 1; pp. 25091 - 15
Main Authors Kado, Akira, Moriya, Kyoji, Inoue, Yukiko, Yanagimoto, Shintaro, Tsutsumi, Takeya, Koike, Kazuhiko, Fujishiro, Mitsuhiro
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 23.10.2024
Nature Publishing Group
Nature Portfolio
Subjects
631/154/570
631/208/199
631/80/86/2366
692/53/2423
692/699/1503/1607/1608
Adult
Alcohol
Alcohol Drinking - adverse effects
Alcohol use
Alcohols
Antioxidant gene expression
Antioxidants
Antioxidants - metabolism
Early ethanol exposure
Ethanol
Gene expression
Humanities and Social Sciences
Humans
Leukocytes (mononuclear)
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Male
multidisciplinary
Oxidative stress
Oxidative Stress - drug effects
Peripheral blood mononuclear cells
Peripheral immune cells
Science
Science (multidisciplinary)
SOD1
Superoxide dismutase
Superoxide Dismutase - blood
Superoxide Dismutase - genetics
Superoxide Dismutase - metabolism
Superoxide Dismutase-1 - genetics
Superoxide Dismutase-1 - metabolism
Young Adult
Young adults
Oxidative stress
Peripheral immune cells
Young adults
Antioxidant gene expression
Early ethanol exposure
SOD1
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Abstract Alcohol consumption increases oxidative stress and imbalances in the antioxidant system, even with ethanol (EtOH) exposure at a young age. This study assessed changes in the antioxidant system following young EtOH exposure in peripheral immunity and measured sensitive indicators of heavy alcohol consumption. We used peripheral blood mononuclear cells (PBMCs) from 197 male university students without smoking habits to examine changes in antioxidant-related gene expression in vitro and in PBMCs. In vitro, the antioxidant system was impaired by EtOH. Next, we examined the expression of 84 antioxidant-related genes in the PBMCs of 162 young adults, among which the superoxide dismutase (SOD) 1 expression was most negatively correlated with alcohol consumption degree. The plasma SOD1 level had the highest area under the curve value (0.806) for heavy alcohol consumption. Our data demonstrated that a decreased SOD1 level is a sensitive indicator of an impaired antioxidant system and heavy alcohol consumption with early EtOH exposure.
AbstractList Alcohol consumption increases oxidative stress and imbalances in the antioxidant system, even with ethanol (EtOH) exposure at a young age. This study assessed changes in the antioxidant system following young EtOH exposure in peripheral immunity and measured sensitive indicators of heavy alcohol consumption. We used peripheral blood mononuclear cells (PBMCs) from 197 male university students without smoking habits to examine changes in antioxidant-related gene expression in vitro and in PBMCs. In vitro, the antioxidant system was impaired by EtOH. Next, we examined the expression of 84 antioxidant-related genes in the PBMCs of 162 young adults, among which the superoxide dismutase (SOD) 1 expression was most negatively correlated with alcohol consumption degree. The plasma SOD1 level had the highest area under the curve value (0.806) for heavy alcohol consumption. Our data demonstrated that a decreased SOD1 level is a sensitive indicator of an impaired antioxidant system and heavy alcohol consumption with early EtOH exposure.
Alcohol consumption increases oxidative stress and imbalances in the antioxidant system, even with ethanol (EtOH) exposure at a young age. This study assessed changes in the antioxidant system following young EtOH exposure in peripheral immunity and measured sensitive indicators of heavy alcohol consumption. We used peripheral blood mononuclear cells (PBMCs) from 197 male university students without smoking habits to examine changes in antioxidant-related gene expression in vitro and in PBMCs. In vitro, the antioxidant system was impaired by EtOH. Next, we examined the expression of 84 antioxidant-related genes in the PBMCs of 162 young adults, among which the superoxide dismutase (SOD) 1 expression was most negatively correlated with alcohol consumption degree. The plasma SOD1 level had the highest area under the curve value (0.806) for heavy alcohol consumption. Our data demonstrated that a decreased SOD1 level is a sensitive indicator of an impaired antioxidant system and heavy alcohol consumption with early EtOH exposure.Alcohol consumption increases oxidative stress and imbalances in the antioxidant system, even with ethanol (EtOH) exposure at a young age. This study assessed changes in the antioxidant system following young EtOH exposure in peripheral immunity and measured sensitive indicators of heavy alcohol consumption. We used peripheral blood mononuclear cells (PBMCs) from 197 male university students without smoking habits to examine changes in antioxidant-related gene expression in vitro and in PBMCs. In vitro, the antioxidant system was impaired by EtOH. Next, we examined the expression of 84 antioxidant-related genes in the PBMCs of 162 young adults, among which the superoxide dismutase (SOD) 1 expression was most negatively correlated with alcohol consumption degree. The plasma SOD1 level had the highest area under the curve value (0.806) for heavy alcohol consumption. Our data demonstrated that a decreased SOD1 level is a sensitive indicator of an impaired antioxidant system and heavy alcohol consumption with early EtOH exposure.
Abstract Alcohol consumption increases oxidative stress and imbalances in the antioxidant system, even with ethanol (EtOH) exposure at a young age. This study assessed changes in the antioxidant system following young EtOH exposure in peripheral immunity and measured sensitive indicators of heavy alcohol consumption. We used peripheral blood mononuclear cells (PBMCs) from 197 male university students without smoking habits to examine changes in antioxidant-related gene expression in vitro and in PBMCs. In vitro, the antioxidant system was impaired by EtOH. Next, we examined the expression of 84 antioxidant-related genes in the PBMCs of 162 young adults, among which the superoxide dismutase (SOD) 1 expression was most negatively correlated with alcohol consumption degree. The plasma SOD1 level had the highest area under the curve value (0.806) for heavy alcohol consumption. Our data demonstrated that a decreased SOD1 level is a sensitive indicator of an impaired antioxidant system and heavy alcohol consumption with early EtOH exposure.
ArticleNumber 25091
Author Tsutsumi, Takeya
Fujishiro, Mitsuhiro
Koike, Kazuhiko
Inoue, Yukiko
Kado, Akira
Moriya, Kyoji
Yanagimoto, Shintaro
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  givenname: Kyoji
  surname: Moriya
  fullname: Moriya, Kyoji
  email: moriyakyojl0720@gmail.com
  organization: Division of Infection Control and Prevention, Education Research Center, Tokyo Health Care University, Department of Infection Control and Prevention, Graduate School of Medicine, The University of Tokyo
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  givenname: Yukiko
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  fullname: Inoue, Yukiko
  organization: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Division for Health Service Promotion, The University of Tokyo
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  givenname: Shintaro
  surname: Yanagimoto
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  givenname: Kazuhiko
  surname: Koike
  fullname: Koike, Kazuhiko
  organization: Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Department of Gastroenterology, Kanto Central Hospital
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  givenname: Mitsuhiro
  surname: Fujishiro
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Keywords Oxidative stress
Peripheral immune cells
Young adults
Antioxidant gene expression
Early ethanol exposure
SOD1
Language English
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Snippet Alcohol consumption increases oxidative stress and imbalances in the antioxidant system, even with ethanol (EtOH) exposure at a young age. This study assessed...
Abstract Alcohol consumption increases oxidative stress and imbalances in the antioxidant system, even with ethanol (EtOH) exposure at a young age. This study...
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SubjectTerms 631/154/570
631/208/199
631/80/86/2366
692/53/2423
692/699/1503/1607/1608
Adult
Alcohol
Alcohol Drinking - adverse effects
Alcohol use
Alcohols
Antioxidant gene expression
Antioxidants
Antioxidants - metabolism
Early ethanol exposure
Ethanol
Gene expression
Humanities and Social Sciences
Humans
Leukocytes (mononuclear)
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Male
multidisciplinary
Oxidative stress
Oxidative Stress - drug effects
Peripheral blood mononuclear cells
Peripheral immune cells
Science
Science (multidisciplinary)
SOD1
Superoxide dismutase
Superoxide Dismutase - blood
Superoxide Dismutase - genetics
Superoxide Dismutase - metabolism
Superoxide Dismutase-1 - genetics
Superoxide Dismutase-1 - metabolism
Young Adult
Young adults
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Title Decreased antioxidant-related superoxide dismutase 1 expression in peripheral immune cells indicates early ethanol exposure
URI https://link.springer.com/article/10.1038/s41598-024-76084-8
https://www.ncbi.nlm.nih.gov/pubmed/39443615
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https://www.proquest.com/docview/3120058759
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Volume 14
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