Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 27; pp. 10972 - 10977
• Main Authors: Kovalchuk, Alexander L, Ansarah-Sobrinho, Camilo, Hakim, Ofir, Resch, Wolfgang, Tolarová, Helena, Dubois, Wendy, Yamane, Arito, Takizawa, Makiko, Klein, Isaac, Hager, Gordon L, Morse, Herbert C, Potter, Michael, Nussenzweig, Michel C, Casellas, Rafael
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 03.07.2012; National Acad Sciences
• Subjects: Africans; animal models; Animals; B lymphocytes; B-Lymphocytes - cytology; B-Lymphocytes - physiology; Biological Sciences; Burkitt lymphoma; Burkitt Lymphoma - epidemiology; Burkitt Lymphoma - genetics; Cells, Cultured; children; Chromatin; chromosome translocation; Chromosomes; cytidine; Cytidine - genetics; Disease Models, Animal; Endemic Diseases; Enhancer Elements, Genetic - genetics; Epigenesis, Genetic - genetics; Epigenetics; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene Rearrangement, B-Lymphocyte - genetics; Genes, Immunoglobulin Heavy Chain - genetics; Genes, myc - genetics; Genetic loci; histones; Human herpesvirus 4; Humans; Immunoglobulin Class Switching - genetics; Lymphoma; lysine; malaria; Mice; neoplasm cells; Oncogene Proteins, Fusion - genetics; Oncogenes; Plasma cells; Plasma Cells - cytology; Plasma Cells - physiology; Plasmacytoma; precipitin tests; regulatory sequences; Rodents; transcription (genetics); Transcription Initiation Site - physiology; Translocation, Genetic - genetics; Tumors; uracil; Uracil-DNA Glycosidase - genetics

Human Burkitt lymphomas are divided into two main clinical variants: the endemic form, affecting African children infected with malaria and the Epstein-Barr virus, and the sporadic form, distributed across the rest of the world. However, whereas sporadic translocations decapitate Myc from 5′ proxima...