IL-25 Enhances HSV-1 Replication by Inhibiting Filaggrin Expression, and Acts Synergistically with Th2 Cytokines to Enhance HSV-1 Replication

• Published in: Journal of investigative dermatology Vol. 133; no. 12; pp. 2678 - 2685
• Main Authors: Kim, Byung Eui, Bin, Lianghua, Ye, Young-Min, Ramamoorthy, Preveen, Leung, Donald Y.M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2013; Elsevier Limited
• Subjects: Atopic dermatitis; Biopsy; Dermatitis, Atopic - complications; Dermatitis, Atopic - metabolism; Dermatitis, Atopic - virology; Filaggrin Proteins; Gene Expression Regulation; Gene Silencing; Genotype; Herpes simplex virus 1; Herpesvirus 1, Human - physiology; Humans; Interferon-gamma - metabolism; Interleukin-13 - metabolism; Interleukin-17 - physiology; Interleukin-4 - metabolism; Intermediate Filament Proteins - metabolism; Kaposi Varicelliform Eruption - complications; Kaposi Varicelliform Eruption - metabolism; Kaposi Varicelliform Eruption - virology; Psoriasis - metabolism; RNA, Small Interfering - metabolism; Skin - metabolism; Skin Diseases - virology; Th2 Cells - metabolism; Vaccinia virus - metabolism; Virus Diseases - metabolism; Virus Replication

Atopic dermatitis (AD) is characterized by epidermal barrier defects and recurrent microbial skin infections. AD patients with a history of eczema herpeticum (ADEH+) have more severe skin disease and more highly T helper type 2 (Th2)–polarized immune responses as compared with uncomplicated AD (ADEH...