Development of broadly protective influenza B vaccines
Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans and, in some cases, death. During the last 50 years, influenza B viruses of two antigenically distinct lineages (termed ‘Victoria’ and ‘Yamagata’) have circulated in humans, nece...
Saved in:
| Published in | npj vaccines Vol. 10; no. 1; pp. 2 - 9 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
07.01.2025
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans and, in some cases, death. During the last 50 years, influenza B viruses of two antigenically distinct lineages (termed ‘Victoria’ and ‘Yamagata’) have circulated in humans, necessitating two different influenza B vaccine strains. In this study, we devised a novel vaccine strategy involving reciprocal amino acid substitutions at sites where Victoria- and Yamagata-lineage viruses differ, leading to the generation of ‘hybrid’ vaccine viruses with the potential to protect against both lineages. Based on antigenic characterization, we selected two candidates and assessed their protective efficacy in a ferret model. Notably, both recombinant HA proteins conferred enhanced protection against heterologous challenges compared to their respective wild-type antigens. These findings show the potential of our novel strategy to develop cross-lineage protective influenza B virus vaccines. |
|---|---|
| AbstractList | Abstract Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans and, in some cases, death. During the last 50 years, influenza B viruses of two antigenically distinct lineages (termed ‘Victoria’ and ‘Yamagata’) have circulated in humans, necessitating two different influenza B vaccine strains. In this study, we devised a novel vaccine strategy involving reciprocal amino acid substitutions at sites where Victoria- and Yamagata-lineage viruses differ, leading to the generation of ‘hybrid’ vaccine viruses with the potential to protect against both lineages. Based on antigenic characterization, we selected two candidates and assessed their protective efficacy in a ferret model. Notably, both recombinant HA proteins conferred enhanced protection against heterologous challenges compared to their respective wild-type antigens. These findings show the potential of our novel strategy to develop cross-lineage protective influenza B virus vaccines. Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans and, in some cases, death. During the last 50 years, influenza B viruses of two antigenically distinct lineages (termed 'Victoria' and 'Yamagata') have circulated in humans, necessitating two different influenza B vaccine strains. In this study, we devised a novel vaccine strategy involving reciprocal amino acid substitutions at sites where Victoria- and Yamagata-lineage viruses differ, leading to the generation of 'hybrid' vaccine viruses with the potential to protect against both lineages. Based on antigenic characterization, we selected two candidates and assessed their protective efficacy in a ferret model. Notably, both recombinant HA proteins conferred enhanced protection against heterologous challenges compared to their respective wild-type antigens. These findings show the potential of our novel strategy to develop cross-lineage protective influenza B virus vaccines. Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans and, in some cases, death. During the last 50 years, influenza B viruses of two antigenically distinct lineages (termed 'Victoria' and 'Yamagata') have circulated in humans, necessitating two different influenza B vaccine strains. In this study, we devised a novel vaccine strategy involving reciprocal amino acid substitutions at sites where Victoria- and Yamagata-lineage viruses differ, leading to the generation of 'hybrid' vaccine viruses with the potential to protect against both lineages. Based on antigenic characterization, we selected two candidates and assessed their protective efficacy in a ferret model. Notably, both recombinant HA proteins conferred enhanced protection against heterologous challenges compared to their respective wild-type antigens. These findings show the potential of our novel strategy to develop cross-lineage protective influenza B virus vaccines.Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans and, in some cases, death. During the last 50 years, influenza B viruses of two antigenically distinct lineages (termed 'Victoria' and 'Yamagata') have circulated in humans, necessitating two different influenza B vaccine strains. In this study, we devised a novel vaccine strategy involving reciprocal amino acid substitutions at sites where Victoria- and Yamagata-lineage viruses differ, leading to the generation of 'hybrid' vaccine viruses with the potential to protect against both lineages. Based on antigenic characterization, we selected two candidates and assessed their protective efficacy in a ferret model. Notably, both recombinant HA proteins conferred enhanced protection against heterologous challenges compared to their respective wild-type antigens. These findings show the potential of our novel strategy to develop cross-lineage protective influenza B virus vaccines. |
| ArticleNumber | 2 |
| Author | Kawaoka, Yoshihiro Babujee, Lavanya Neumann, Gabriele Pattinson, David Jester, Peter Maemura, Tadashi Gu, Chunyang Chiba, Shiho |
| Author_xml | – sequence: 1 givenname: Chunyang surname: Gu fullname: Gu, Chunyang organization: Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison – sequence: 2 givenname: Lavanya surname: Babujee fullname: Babujee, Lavanya organization: Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison – sequence: 3 givenname: David surname: Pattinson fullname: Pattinson, David organization: Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison – sequence: 4 givenname: Shiho surname: Chiba fullname: Chiba, Shiho organization: Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison – sequence: 5 givenname: Peter surname: Jester fullname: Jester, Peter organization: Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison – sequence: 6 givenname: Tadashi surname: Maemura fullname: Maemura, Tadashi organization: Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison – sequence: 7 givenname: Gabriele surname: Neumann fullname: Neumann, Gabriele email: gabriele.neumann@wisc.edu organization: Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison – sequence: 8 givenname: Yoshihiro surname: Kawaoka fullname: Kawaoka, Yoshihiro email: yoshihiro.kawaoka@wisc.edu organization: Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison, Division of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, The Institute of Medical Science, University of Tokyo, The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Pandemic Preparedness, Infection and Advanced Research Center, University of Tokyo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39774170$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kk1v1DAQhi1UREvpH-CAInHhkjL-ip0TggKlUiUucLYcZ7xklbUXO9mq_Hq8m1JaDpxsj595Zzx-n5OjEAMS8pLCOQWu32ZBpaA1MFEDBanrmyfkhIFsD8ejB_tjcpbzGgCoarhU8Iwc81YpQRWckOYj7nCM2w2GqYq-6lK0_XhbbVOc0E3DDqsh-HHG8MtWH6qddW4ImF-Qp96OGc_u1lPy_fOnbxdf6uuvl1cX769rJ1o21aIFIbymnedKtxZ7EA4U7yzte2TcM90wq6wH1N5KpFqr0jBXvXd7FvkpuVp0-2jXZpuGjU23JtrBHAIxrYxN0-BGNNzZjrOWaVeK6kZZDX3XN7IH8FJrX7TeLVrbudtg78qLkx0fiT6-CcMPs4o7Q8ukFGhZFN7cKaT4c8Y8mc2QHY6jDRjnbDiVXCvBWlrQ1_-g6zinUGa1pxhvpG6gUK8etnTfy5__KQBbAJdizgn9PULB7H1gFh-Y4gNz8IG5KUl8ScoFDitMf2v_J-s3_oq0QQ |
| Cites_doi | 10.1038/s41541-017-0026-4 10.3389/fimmu.2021.746447 10.1016/S0140-6736(17)33293-2 10.1016/j.coi.2018.04.002 10.1038/s41467-022-29402-5 10.1155/2018/9695628 10.1128/JVI.01715-13 10.1080/21645515.2024.2356269 10.1093/bioinformatics/btz305 10.1038/s41591-020-0937-x 10.1016/0378-1119(91)90434-D 10.1016/j.coviro.2013.07.007 10.3389/fimmu.2024.1334670 10.1128/JVI.01118-06 10.1073/pnas.2211616119 10.1038/s41588-021-00862-7 10.1038/s41541-019-0126-4 10.7717/peerj-cs.1516 10.1128/JVI.00946-18 10.1128/JVI.00808-15 10.1128/JVI.00333-19 10.1016/j.vaccine.2022.12.005 10.1016/j.vaccine.2009.11.068 10.1128/JVI.00286-17 10.1073/pnas.1616530113 10.1016/j.vaccine.2019.03.018 10.1111/irv.12522 10.1111/imr.12887 10.1038/s41564-019-0433-6 10.1038/s41598-023-43003-2 10.1128/JVI.01336-12 10.1073/pnas.96.16.9345 10.1128/JVI.03183-13 10.1093/molbev/mst010 10.1128/JVI.00137-12 10.1128/mbio.00622-23 10.1126/science.1097211 10.1128/JVI.02421-20 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2024 2024. The Author(s). Copyright Nature Publishing Group 2025 The Author(s) 2024 2024 |
| Copyright_xml | – notice: The Author(s) 2024 – notice: 2024. The Author(s). – notice: Copyright Nature Publishing Group 2025 – notice: The Author(s) 2024 2024 |
| DBID | C6C AAYXX CITATION NPM 3V. 7RV 7X7 7XB 88C 8C1 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BENPR CCPQU COVID DWQXO FYUFA GHDGH K9- K9. KB0 M0R M0S M0T NAPCQ PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.1038/s41541-024-01058-w |
| DatabaseName | Springer Nature OA Free Journals CrossRef PubMed ProQuest Central (Corporate) Proquest Nursing & Allied Health Source Health & Medical Collection ProQuest Central (purchase pre-March 2016) Healthcare Administration Database (Alumni) Public Health Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College Coronavirus Research Database ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) Consumer Health Database ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Consumer Health Database ProQuest Health & Medical Collection Healthcare Administration Database Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest Publicly Available Content ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Family Health (Alumni Edition) ProQuest Central China ProQuest Central ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Public Health ProQuest Family Health ProQuest One Academic Eastern Edition ProQuest Health Management Coronavirus Research Database ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Health Management (Alumni Edition) ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 2059-0105 |
| EndPage | 9 |
| ExternalDocumentID | oai_doaj_org_article_3cab32928c904867a80dbd65d00f588f PMC11707085 39774170 10_1038_s41541_024_01058_w |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: National Institute of Allergy and Infectious Diseases grantid: 4R33AI159937-03 funderid: http://dx.doi.org/10.13039/100000060 – fundername: National Institute of Allergy and Infectious Diseases grantid: 4R33AI159937-03 |
| GroupedDBID | 0R~ 53G 5VS 7RV 7X7 8C1 8FI 8FJ AAJSJ ABUWG ACGFS ACSMW ADBBV AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BCNDV BENPR C6C CCPQU EBLON EBS ECGQY FYUFA GROUPED_DOAJ HMCUK HYE K9- KQ8 M0R M0T M~E NAO NAPCQ OK1 PGMZT PIMPY RNT RPM SNYQT UKHRP AASML AAYXX CITATION PHGZM PHGZT NPM PJZUB PPXIY 3V. 7XB 8FK AARCD COVID DWQXO K9. PKEHL PQEST PQQKQ PQUKI PRINS 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c492t-49044f81bf3789aed04c073ba1dde23f2862a7af0e8fa5e188710537dfced04e3 |
| IEDL.DBID | AAJSJ |
| ISSN | 2059-0105 |
| IngestDate | Wed Aug 27 01:27:30 EDT 2025 Thu Aug 21 18:28:22 EDT 2025 Fri Jul 11 10:12:11 EDT 2025 Wed Aug 13 09:47:15 EDT 2025 Mon Jul 21 05:47:01 EDT 2025 Tue Jul 01 04:21:19 EDT 2025 Fri Feb 21 02:35:07 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2024. The Author(s). Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c492t-49044f81bf3789aed04c073ba1dde23f2862a7af0e8fa5e188710537dfced04e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://www.nature.com/articles/s41541-024-01058-w |
| PMID | 39774170 |
| PQID | 3152365860 |
| PQPubID | 4669711 |
| PageCount | 9 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_3cab32928c904867a80dbd65d00f588f pubmedcentral_primary_oai_pubmedcentral_nih_gov_11707085 proquest_miscellaneous_3153874291 proquest_journals_3152365860 pubmed_primary_39774170 crossref_primary_10_1038_s41541_024_01058_w springer_journals_10_1038_s41541_024_01058_w |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2025-01-07 |
| PublicationDateYYYYMMDD | 2025-01-07 |
| PublicationDate_xml | – month: 01 year: 2025 text: 2025-01-07 day: 07 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | npj vaccines |
| PublicationTitleAbbrev | npj Vaccines |
| PublicationTitleAlternate | NPJ Vaccines |
| PublicationYear | 2025 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | O Abril-Pla (1058_CR40) 2023; 9 DJ Smith (1058_CR21) 2004; 305 R Hai (1058_CR10) 2012; 86 GA Sautto (1058_CR27) 2021; 95 JD Allen (1058_CR24) 2024; 15 F Krammer (1058_CR13) 2012; 86 1058_CR2 V Dhanasekaran (1058_CR3) 2022; 13 MA Carlock (1058_CR17) 2023; 13 F Broecker (1058_CR9) 2019; 4 I Margine (1058_CR14) 2013 W Sun (1058_CR28) 2019; 93 AD Iuliano (1058_CR1) 2018; 391 G Neumann (1058_CR19) 1999; 96 J Tan (1058_CR6) 2018; 53 1058_CR7 S Chiba (1058_CR32) 2023; 41 I Kiseleva (1058_CR23) 2018; 2018 L Jennings (1058_CR5) 2018; 12 S Chiba (1058_CR18) 2023; 14 E Bottcher (1058_CR34) 2006; 80 TM Ross (1058_CR26) 2019; 37 JD Allen (1058_CR31) 2019; 93 F Krammer (1058_CR11) 2014; 88 JK Park (1058_CR30) 2020; 26 Y Liu (1058_CR29) 2021; 12 ME Ermler (1058_CR16) 2017; 91 K Takada (1058_CR33) 2019 H Niwa (1058_CR39) 1991; 108 J Ping (1058_CR20) 2016; 113 RB Belshe (1058_CR4) 2010; 28 ME Rosu (1058_CR22) 2022; 119 F Krammer (1058_CR12) 2013; 3 Y Turakhia (1058_CR37) 2021; 53 H Fukuyama (1058_CR8) 2020; 296 H Shi (1058_CR25) 2024; 20 K Katoh (1058_CR35) 2013; 30 PS Lee (1058_CR38) 2015; 89 R Nachbagauer (1058_CR15) 2017; 2 AM Kozlov (1058_CR36) 2019; 35 |
| References_xml | – volume: 2 year: 2017 ident: 1058_CR15 publication-title: NPJ Vaccines doi: 10.1038/s41541-017-0026-4 – volume: 12 year: 2021 ident: 1058_CR29 publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.746447 – volume: 391 start-page: 1285 year: 2018 ident: 1058_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(17)33293-2 – volume: 53 start-page: 45 year: 2018 ident: 1058_CR6 publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2018.04.002 – ident: 1058_CR7 – volume: 13 year: 2022 ident: 1058_CR3 publication-title: Nat. Commun. doi: 10.1038/s41467-022-29402-5 – volume: 2018 year: 2018 ident: 1058_CR23 publication-title: Biomed. Res. Int. doi: 10.1155/2018/9695628 – year: 2013 ident: 1058_CR14 publication-title: J. Virol. doi: 10.1128/JVI.01715-13 – volume: 20 start-page: 2356269 year: 2024 ident: 1058_CR25 publication-title: Hum. Vaccin Immunother. doi: 10.1080/21645515.2024.2356269 – volume: 35 start-page: 4453 year: 2019 ident: 1058_CR36 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btz305 – volume: 26 start-page: 1240 year: 2020 ident: 1058_CR30 publication-title: Nat. Med. doi: 10.1038/s41591-020-0937-x – volume: 108 start-page: 193 year: 1991 ident: 1058_CR39 publication-title: Gene doi: 10.1016/0378-1119(91)90434-D – volume: 3 start-page: 521 year: 2013 ident: 1058_CR12 publication-title: Curr. Opin. Virol. doi: 10.1016/j.coviro.2013.07.007 – volume: 15 year: 2024 ident: 1058_CR24 publication-title: Front. Immunol. doi: 10.3389/fimmu.2024.1334670 – volume: 80 start-page: 9896 year: 2006 ident: 1058_CR34 publication-title: J. Virol. doi: 10.1128/JVI.01118-06 – volume: 119 year: 2022 ident: 1058_CR22 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.2211616119 – volume: 53 start-page: 809 year: 2021 ident: 1058_CR37 publication-title: Nat. Genet. doi: 10.1038/s41588-021-00862-7 – volume: 4 year: 2019 ident: 1058_CR9 publication-title: NPJ Vaccines doi: 10.1038/s41541-019-0126-4 – volume: 9 year: 2023 ident: 1058_CR40 publication-title: PeerJ Comput. Sci. doi: 10.7717/peerj-cs.1516 – volume: 93 start-page: e00946 year: 2019 ident: 1058_CR31 publication-title: J. Virol. doi: 10.1128/JVI.00946-18 – volume: 89 start-page: 7417 year: 2015 ident: 1058_CR38 publication-title: J. Virol. doi: 10.1128/JVI.00808-15 – volume: 93 start-page: e00333 year: 2019 ident: 1058_CR28 publication-title: J. Virol. doi: 10.1128/JVI.00333-19 – volume: 41 start-page: 590 year: 2023 ident: 1058_CR32 publication-title: Vaccine doi: 10.1016/j.vaccine.2022.12.005 – ident: 1058_CR2 – volume: 28 start-page: 2149 year: 2010 ident: 1058_CR4 publication-title: Vaccine doi: 10.1016/j.vaccine.2009.11.068 – volume: 91 start-page: e00286 year: 2017 ident: 1058_CR16 publication-title: J. Virol. doi: 10.1128/JVI.00286-17 – volume: 113 start-page: E8296 year: 2016 ident: 1058_CR20 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1616530113 – volume: 37 start-page: 2369 year: 2019 ident: 1058_CR26 publication-title: Vaccine doi: 10.1016/j.vaccine.2019.03.018 – volume: 12 start-page: 383 year: 2018 ident: 1058_CR5 publication-title: Influenza Respir. Viruses doi: 10.1111/irv.12522 – volume: 296 start-page: 132 year: 2020 ident: 1058_CR8 publication-title: Immunol. Rev. doi: 10.1111/imr.12887 – year: 2019 ident: 1058_CR33 publication-title: Nat. Microbiol. doi: 10.1038/s41564-019-0433-6 – volume: 13 year: 2023 ident: 1058_CR17 publication-title: Sci. Rep. doi: 10.1038/s41598-023-43003-2 – volume: 86 start-page: 10302 year: 2012 ident: 1058_CR13 publication-title: J. Virol. doi: 10.1128/JVI.01336-12 – volume: 96 start-page: 9345 year: 1999 ident: 1058_CR19 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.96.16.9345 – volume: 88 start-page: 2340 year: 2014 ident: 1058_CR11 publication-title: J. Virol. doi: 10.1128/JVI.03183-13 – volume: 30 start-page: 772 year: 2013 ident: 1058_CR35 publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/mst010 – volume: 86 start-page: 5774 year: 2012 ident: 1058_CR10 publication-title: J. Virol. doi: 10.1128/JVI.00137-12 – volume: 14 start-page: e0062223 year: 2023 ident: 1058_CR18 publication-title: mBio doi: 10.1128/mbio.00622-23 – volume: 305 start-page: 371 year: 2004 ident: 1058_CR21 publication-title: Science doi: 10.1126/science.1097211 – volume: 95 year: 2021 ident: 1058_CR27 publication-title: J. Virol. doi: 10.1128/JVI.02421-20 |
| SSID | ssj0001763570 |
| Score | 2.28602 |
| Snippet | Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans and, in some cases, death. During the... Abstract Influenza B viruses pose a significant threat to global public health, leading to severe respiratory infections in humans and, in some cases, death.... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 2 |
| SubjectTerms | 631/326/590 631/326/596/1578 Amino acids Antibodies Antigens Biomedical and Life Sciences Biomedicine Genes Global health Immunization Infections Infectious Diseases Influenza Medical Microbiology Mutation Pandemics Public Health Severe acute respiratory syndrome coronavirus 2 Vaccine Vaccines Virology Viruses |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JTsMwELUQJy6InbDJSKgXGtWN7cQ5AqKqOCAOVOrNcrwIJJQiUkDl6xk76cYiLlwTHyZv4pk3Xt4gdOYvLxaM29ivB8bM0jTOlRMxFWmqU6OB4Qe1z9u0P2A3Qz5caPXlz4TV8sA1cB2qVUGTPBE6D-pwShBTmJQbQhwXwvnoCzlvoZgKqytBZ400t2QIFZ0KMhWDyjnxhy4IF_H7UiYKgv0_sczvhyW_7JiGRNTbQOsNg8QXteWbaMWWW6h1V0tQT9r4fn6jqmrjFr6bi1NPtlG6cEoIjxwuXkbKPE1wo9cAsQ8_1n1LPhS-xG9K-533agcNetf3V_246Z0Qa5Yn45gBWswBJ3U0E7myhjANs7lQXYhnCXUJVDIqU45Y4RS3XYg1XS_tYpz2Yy3dRavlqLT7CBvhnFZcUc0os4wXrsiNU4KLxEAxSCJ0PsVRPtcSGTJsbVMha9QloC4D6vI9Qpce6tlIL28dHoDTZeN0-ZfTI3Q0dZRs5lwlKVARCoQqBYtOZ69htvgtEFXa0WsYQ0UGObgbob3arzNLAhUO3yOWPL5k6vKb8vEhKHL79j0ZkNcItac_x9yu37E4-A8sDtFa4nsS-2Wh7Aitjl9e7TEQpXFxEubEJ0wxDzE priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1JT9wwFH5q6aVShYBuYZMrVVw6Fp7YTpwTgqoI9VBxAGluluOlRUIJnQyg4ddjO54J04Vr4oPtt_ot3wP4HJoXa8YtDvFAzCwtcKWcwFQUhS6M9h5-RPv8UZxdsu8TPkkBty6VVS50YlTUptUhRn5IvaGh3lwW5OjmNw5To0J2NY3QeAmvAnRZ4OpyUg4xloi2RlKvDKHisPP2ivn3cx5KLwgX-H7FHkXY_n_5mn-XTP6RN43m6HQD1pMfiY57wm_CC9tswcF5D0Q9H6GLoa-qG6EDdD5AVM-34E0frUN9E9JbKJ7UDqHWoXraKnM9RwnFwWtEdNVPM3lQ6ATdKR3y8d07uDz9dvH1DKeJClizKp9hVhHGnPdUHS1FpawhTHsZr9XYa7mcuty_b1SpHLHCKW7HXgONA-CLcTqstfQ9rDVtYz8CMsI5rbiimlFmGa9dXRmnBBe58U9EksGXxb3Kmx44Q8aENxWyp4L0VJCRCvI-g5Nw9cuVAfQ6fminP2WSIUm1qmle5UJXEShQCWJqU3BDiONCuAx2F4STSRI7OfBNBp-Wv70MhcSIamx7G9dQUXrLPM7gQ0_n5U6igxzPI1Y4YGWrq3-aq18RpzsM9Sm9S5vBaMEsw77-fxfbzx9jB17nYQZxCAOVu7A2m97aPe8Yzer9yP2Pi_UL3g priority: 102 providerName: ProQuest |
| Title | Development of broadly protective influenza B vaccines |
| URI | https://link.springer.com/article/10.1038/s41541-024-01058-w https://www.ncbi.nlm.nih.gov/pubmed/39774170 https://www.proquest.com/docview/3152365860 https://www.proquest.com/docview/3153874291 https://pubmed.ncbi.nlm.nih.gov/PMC11707085 https://doaj.org/article/3cab32928c904867a80dbd65d00f588f |
| Volume | 10 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED_t4wUJIRhfgVEZCe2FRiS2kziPbbVpKtJUYJP6Zjn-GJNQgtqOqfz1nJ2kpTAeeEkk25EuPn_8fL77HcA7H7xY8czG3h4Yc8vyuFROxEzkuc6NRoQf2D4v8vMrPp1n8z2gfSxMcNoPlJZhme69wz4scaPhePCl3mciyUR8tw-Hnqodx_bhaDT9Mt1aVgLHWtJFyCRM3PPxzi4UyPrvQ5h_O0r-cVsaNqGzx_CoQ49k1Mr7BPZsfQQns5Z-ej0kl9toquWQnJDZlph6fQQPWxsdaUOPnkL-m8cQaRypFo0y39ak427AdZDctDlMfioyJj-U9rfwy2dwdXZ6OTmPuzwKseYlXcW8TDh3iE8dK0SprEm4xpldqRTXNsocxVONKpRLrHAqsymuO6mneTFO-7aWPYeDuqntSyBGOKdVppjmjFueVa4qjVMiE9TgwTCJ4H3fr_J7S5chwzU3E7LVgkQtyKAFeRfB2Hf9pqWnug4FzeJadqqXTKuK0ZIKXQZ6QCUSU5k8M0niMiFcBMe94mQ3_5aSISxhCK5ylOjtphpnjr8OUbVtbkMbhiOIlmkEL1o9byQJsDj8j9gZATui7tbUN18DO7dP5VMgkI1g2A-WrVz_7otX_9f8NTygPhOxNwYVx3CwWtzaNwiPVtUA9ot5gU8xSQfd3MD3-PRi9hlLJ_lkEAwP-Pz4SfwCSksRiA |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VcgAJISivQAEjQS9sVCd2EueAEC1UW1qqHrZSb8bxAyqhTdndslp-FL-RsZNsWF63XhMrcjwzns8znm8AnvvixYpnNvbxwJhblselciJmIs91bjQi_MD2eZQPT_j70-x0DX50tTD-WmW3J4aN2tTax8i3GToahu4yp6_Pv8a-a5TPrnYtNBq1OLCLOR7Zpq_236J8X6Tp3rvR7jBuuwrEmpfpLOYl5dwhWnOsEKWyhnKNel6pBC09ZS5FjK8K5agVTmU2QStMPOmJcdqPtQy_ewWucoam6SvTd5M-phPY3Whbm0OZ2J6if-R4Xk_9VQ-aiXi-4v9Cm4C_Yds_r2j-lqcN7m_vFtxscSt50yjabViz4w3YOm6IrxcDMurruKYDskWOe0rsxQbcaKKDpCl6ugP5L3eVSO1INamV-bIgLWsE7sDkrOme8l2RHfJNaZ__n96Fk0tZ63uwPq7H9gEQI5zTKlNMc8YtzypXlcYpkYnU4JGURvCyW1d53hB1yJBgZ0I2UpAoBRmkIOcR7PilX470JNvhQT35JFublUyriqVlKnQZiAmVoKYyeWYodZkQLoLNTnCytfyp7PU0gmfL12izPhGjxra-CGOYKBAJJBHcb-S8nEkA5OF_xIoGrEx19c347HPgBfdNhAqE0BEMOmXp5_XvtXj4_994CteGow-H8nD_6OARXE99_2Mfgio2YX02ubCPEZTNqifBEgh8vGzT-wnN3EkV |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3fb9MwED6NTkJICMGAETbASGgvNODETuI8dkA1CpoqsUl7sxz_GJNQMrUdU_nrd3aSlsJ44DWxoovPd_fZd_cZ4I1vXqx4ZmN_Hhhzy_K4VE7ETOS5zo1GhB_YPo_zo1M-OcvOtiDve2FC0X6gtAxuuq8Oez_HQMNx45v6mgmaifj63aVxd2Ab8XbCB7A9Gk2-TdanK4FnjXZdMpSJWz6wEYkCYf9tKPPvYsk_MqYhEI0fwoMOQZJRK_Mj2LL1DhxMWwrq5ZCcrDuq5kNyQKZrcurlDtxvz-lI2370GPLfqoZI40g1a5T5sSQdfwP6QnLR3mPyS5FD8lNpn4mfP4HT8aeTD0dxd5dCrHmZLmJeUs4dYlTHClEqayjXaN2VStC_pcyluLNRhXLUCqcym6DvSTzVi3Haj7XsKQzqprbPgBjhnFaZYpozbnlWuao0TolMpAY3hzSCt_28ysuWMkOGVDcTstWCRC3IoAV5HcGhn_rVSE93HR40s3PZqV8yrSqWlqnQZaAIVIKayuSZodRlQrgI9nvFyc4G55IhNGEIsHKU6PXqNVqPT4mo2jZXYQwTBcbkJILdVs8rSQI0Dv8jNlbAhqibb-qL74Gh21_nUyCYjWDYL5a1XP-ei-f_N_wV3J1-HMuvn4-_7MG91F9M7M-Gin0YLGZX9gWipUX1sjONG7NDD2s |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Development+of+broadly+protective+influenza+B+vaccines&rft.jtitle=npj+vaccines&rft.au=Gu%2C+Chunyang&rft.au=Babujee%2C+Lavanya&rft.au=Pattinson%2C+David&rft.au=Chiba%2C+Shiho&rft.date=2025-01-07&rft.issn=2059-0105&rft.eissn=2059-0105&rft.volume=10&rft.issue=1&rft_id=info:doi/10.1038%2Fs41541-024-01058-w&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41541_024_01058_w |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2059-0105&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2059-0105&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2059-0105&client=summon |