Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 43; pp. 17681 - 17686
• Main Authors: Hu, Fei, Ren, Jing, Zhang, Ju-en, Zhong, Weixin, Luo, Minmin
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.10.2012; National Acad Sciences
• Subjects: adenosine; analgesia; Animals; atrial natriuretic peptide; Biological Sciences; Blood pressure; Brain; cAMP-dependent protein kinase; Cyclic AMP-Dependent Protein Kinases - metabolism; cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism; electrophysiology; Female; Gene expression; glutamic acid; heart; Male; Mice; Mice, Inbred C57BL; Modulated signal processing; Natriuretic peptides; Natriuretic Peptides - pharmacology; Neurons; Neurotransmitters; optogenetics; Peptides; Physiological regulation; Presynaptic Terminals - enzymology; Receptors; Rodents; Signal transduction; Synaptic transmission; Synaptic Transmission - drug effects

The heart peptide hormone atrial natriuretic peptide (ANP) regulates blood pressure by stimulating guanylyl cyclase-A to produce cyclic guanosine monophosphate (cGMP). ANP and guanylyl cyclase-A are also expressed in many brain areas, but their physiological functions and downstream signaling pathwa...