Engineering surfaces for site-specific vascular differentiation of mouse embryonic stem cells

• Published in: Acta biomaterialia Vol. 6; no. 6; pp. 1904 - 1916
• Main Authors: Chiang, C. Katherine, Chowdhury, Mohammad Fahad, Iyer, Rohin K., Stanford, William L., Radisic, Milica
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2010
• Subjects: Animals; Biocompatible Materials - administration & dosage; Biocompatible Materials - chemistry; Cell Differentiation - drug effects; Cell Line; Chitosan; Differentiation; Embryonic stem cell; Embryonic Stem Cells - cytology; Embryonic Stem Cells - drug effects; Endothelial cell; Kinases; Lanes; Materials Testing; Mice; Muscles; Patterning; Smooth muscle cell; Sorting; Stem cells; Surface Properties; Tissue Engineering - methods; Tyrosine; Vascular Endothelial Growth Factor A - administration & dosage; Vascular Endothelial Growth Factor A - chemistry; VEGF; Smooth muscle cell; Embryonic stem cell; Patterning; Endothelial cell; VEGF

Differentiation of stem and progenitor cells routinely relies on the application of soluble growth factors, an approach that enables temporal control of cell fate but enables no spatial control of the differentiation process. Angiogenic progenitor cells derived from mouse embryonic stem cells (ESCs)...