Progress and Perspectives on HIV-1 microbicide development

• Published in: Virology (New York, N.Y.) Vol. 497; pp. 69 - 80
• Main Authors: Alexandre, Kabamba B, Mufhandu, Hazel T, London, Grace M, Chakauya, E, Khati, M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2016
• Subjects: Animals; Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Drug Carriers; Drug Delivery Systems; Drug Discovery; Female; Genitalia, Female - virology; HIV Infections - prevention & control; HIV Infections - transmission; HIV Infections - virology; HIV-1; HIV-1 - drug effects; HIV-1 - physiology; Humans; Infectious Disease; Lentivirus; Male; Microbicides; Mucous Membrane - virology; Prevention; Sexual transmission; Sexually Transmitted Diseases, Viral - prevention & control; Sexually Transmitted Diseases, Viral - transmission; Sexually Transmitted Diseases, Viral - virology; Prevention; HIV-1; Sexual transmission; Microbicides

Abstract The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based sexual violence. Despite significant effor...