Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type

• Published in: Blood Vol. 115; no. 6; pp. 1226 - 1237
• Main Authors: Huang, Yenlin, de Reyniès, Aurélien, de Leval, Laurence, Ghazi, Bouchra, Martin-Garcia, Nadine, Travert, Marion, Bosq, Jacques, Brière, Josette, Petit, Barbara, Thomas, Emilie, Coppo, Paul, Marafioti, Teresa, Emile, Jean-François, Delfau-Larue, Marie-Hélène, Schmitt, Christian, Gaulard, Philippe
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 11.02.2010; Americain Society of Hematology; American Society of Hematology
• Series: Lymphoid Neoplasia
• Subjects: Adult; Aged; Biological and medical sciences; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Blotting, Western; Cell Proliferation; Cells, Cultured; Comparative Genomic Hybridization; Epstein-Barr Virus Infections - genetics; Epstein-Barr Virus Infections - metabolism; Epstein-Barr Virus Infections - virology; Female; Gene Expression Profiling; Hematologic and hematopoietic diseases; Herpesvirus 4, Human - physiology; Humans; Immunoenzyme Techniques; Killer Cells, Natural - pathology; Killer Cells, Natural - virology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoid Neoplasia; Lymphoma, Extranodal NK-T-Cell - genetics; Lymphoma, Extranodal NK-T-Cell - metabolism; Lymphoma, Extranodal NK-T-Cell - virology; Male; Medical sciences; Middle Aged; Nasal Mucosa - metabolism; Nasal Mucosa - pathology; Nasopharyngeal Neoplasms - genetics; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - virology; Oligonucleotide Array Sequence Analysis; Oncogenes - physiology; Receptors, Platelet-Derived Growth Factor - genetics; Receptors, Platelet-Derived Growth Factor - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Nose disease; Hematology; Lymphoproliferative syndrome; ENT disease; Nasal NK/T cell lymphoma; Malignant hemopathy; Non Hodgkin lymphoma; Carcinogenesis; Cancer; Gene expression profile

Biopsies and cell lines of natural killer/T-cell lymphoma, nasal type (NKTCL) were subject to combined gene expression profiling and array-based comparative genomic hybridization analyses. Compared with peripheral T-cell lymphoma, not otherwise specified, NKTCL had greater transcript levels for NK-c...