Novel Human Interleukin-15 Agonists

• Published in: The Journal of immunology (1950) Vol. 183; no. 6; pp. 3598 - 3607
• Main Authors: Zhu, Xiaoyun, Marcus, Warren D, Xu, Wenxin, Lee, Hyung-il, Han, Kaiping, Egan, Jack O, Yovandich, Jason L, Rhode, Peter R, Wong, Hing C
• Format: Journal Article
• Language: English
• Published: England Am Assoc Immnol 15.09.2009
• Subjects: Amino Acid Substitution; Animals; Apoptosis; Cell Line; Cell Proliferation - drug effects; Humans; Interleukin-15 - agonists; Interleukin-15 - genetics; Interleukin-15 - pharmacology; Interleukin-15 Receptor alpha Subunit - metabolism; Interleukin-2 Receptor beta Subunit - metabolism; Janus Kinase 1 - metabolism; Mice; Mutagenesis, Site-Directed; Phosphorylation; Species Specificity; STAT5 Transcription Factor - metabolism

IL-15 is an immunostimulatory cytokine trans-presented with the IL-15 receptor α-chain to the shared IL-2/IL-15Rβ and common γ-chains displayed on the surface of T cells and NK cells. To further define the functionally important regions of this cytokine, activity and binding studies were conducted o...