Possible endocannabinoid control of colorectal cancer growth

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 125; no. 3; p. 677
• Main Authors: Ligresti, Alessia, Bisogno, Tiziana, Matias, Isabel, De Petrocellis, Luciano, Cascio, Maria Grazia, Cosenza, Vittorio, D'argenio, Giuseppe, Scaglione, Giuseppe, Bifulco, Maurizio, Sorrentini, Italo, Di Marzo, Vincenzo
• Format: Journal Article
• Language: English
• Published: United States 01.09.2003
• Subjects: Amidohydrolases - metabolism; Caco-2 Cells; Cannabinoid Receptor Modulators; Cell Differentiation; Cell Division; Colorectal Neoplasms - pathology; Colorectal Neoplasms - therapy; Cyclooxygenase 2; Endocannabinoids; Fatty Acids, Unsaturated - analysis; Fatty Acids, Unsaturated - antagonists & inhibitors; Fatty Acids, Unsaturated - physiology; Humans; Isoenzymes - analysis; Isoenzymes - antagonists & inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases - analysis; Receptors, Cannabinoid; Receptors, Drug - analysis

The endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied (1). the levels of endocannabinoids, cannabinoid CB(1) and CB(2) receptors, and fatty acid amide hydrolase (FAAH, which catalyzes endocannabinoid...