Interleukin-21 inhibits dendritic cell activation and maturation

• Published in: Blood Vol. 102; no. 12; pp. 4090 - 4098
• Main Authors: Brandt, Katja, Bulfone-Paus, Silvia, Foster, Donald C., Rückert, René
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.12.2003; The Americain Society of Hematology
• Subjects: Animals; Antigen Presentation; Biological and medical sciences; Bone Marrow Cells; Cell Differentiation - drug effects; Cell Movement; Cells, Cultured; Dendritic Cells - cytology; Dendritic Cells - drug effects; Dendritic Cells - immunology; Drug Interactions; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Immunobiology; Interleukin-15 - pharmacology; Interleukins - pharmacology; Lipopolysaccharides - pharmacology; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Modulation of the immune response (stimulation, suppression); T-Lymphocytes - immunology; Dendritic cell; Vertebrata; Mammalia; Immune response; Mouse; Antigen presenting cell; Animal; Rodentia; Cytokine; Interleukin 21; Immune regulation; Interleukin 15

Interleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15. They belong to a cytokine family that uses the common γ chain for signaling but also have their private high-affinity receptors. Since it is well known that IL-4 modulates differentiation and activation of dendriti...