Multi-landmark alignment of genomic signals reveals conserved expression patterns across transcription start sites

• Published in: Scientific reports Vol. 13; no. 1; p. 10835
• Main Authors: Vilar, Jose M. G., Saiz, Leonor
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.07.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/2785; 631/208/199; Deoxyribonucleic acid; DNA; DNA methylation; Genomics; Genomics - methods; Humanities and Social Sciences; Humans; multidisciplinary; Promoter Regions, Genetic; Science; Science (multidisciplinary); Transcription; Transcription factors; Transcription Initiation Site; Trends

The prevalent one-dimensional alignment of genomic signals to a reference landmark is a cornerstone of current methods to study transcription and its DNA-dependent processes but it is prone to mask potential relations among multiple DNA elements. We developed a systematic approach to align genomic s...