2019–2020 H1N1 clade A5a.1 viruses have better in vitro fitness compared with the co-circulating A5a.2 clade

• Published in: Scientific reports Vol. 13; no. 1; pp. 10223 - 12
• Main Authors: Swanson, Nicholas J., Marinho, Paula, Dziedzic, Amanda, Jedlicka, Anne, Liu, Hsuan, Fenstermacher, Katherine, Rothman, Richard, Pekosz, Andrew
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.06.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/596/1578; 631/326/596/2554; Antigenic drift; Antigens, Viral; Cell culture; Cell differentiation; Clinical isolates; Drift; Epithelial cells; Fitness; Growth curves; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Humanities and Social Sciences; Humans; Influenza; Influenza A Virus, H1N1 Subtype; Influenza, Human - epidemiology; Medical personnel; multidisciplinary; Neutralization; Phylogeny; Polysaccharides; Science; Science (multidisciplinary); Seasons; Vaccines; Viruses

Surveillance for emerging human influenza virus clades is important for identifying changes in viral fitness and assessing antigenic similarity to vaccine strains. While fitness and antigenic structure are both important aspects of virus success, they are distinct characteristics and do not always c...