Evolution of triclosan resistance modulates bacterial permissiveness to multidrug resistance plasmids and phages

• Published in: Nature communications Vol. 15; no. 1; p. 3654
• Main Authors: Yang, Qiu E., Ma, Xiaodan, Li, Minchun, Zhao, Mengshi, Zeng, Lingshuang, He, Minzhen, Deng, Hui, Liao, Hanpeng, Rensing, Christopher, Friman, Ville-Petri, Zhou, Shungui, Walsh, Timothy R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 38/39; 38/91; 42/35; 45/22; 45/23; 45/77; 631/181/2475; 631/326/22/1434; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Antimicrobial agents; Antimicrobial resistance; Antiseptics; Bacteria; Bacteriophages - genetics; Bacteriophages - physiology; Conjugation; Disinfectants; Drug resistance; Drug Resistance, Multiple, Bacterial - genetics; Environmental factors; Environmental stress; Evolution; Evolution, Molecular; Gene expression; Gene sequencing; Gene Transfer, Horizontal; Genetic engineering; Genomes; Horizontal transfer; Humanities and Social Sciences; Klebsiella; Klebsiella pneumoniae; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - genetics; Klebsiella pneumoniae - virology; Membrane potential; multidisciplinary; Multidrug resistance; Mutation; Pathogens; Phages; Plasmids; Plasmids - genetics; Reactive oxygen species; Resistant mutant; Science; Science (multidisciplinary); Transcriptomics; Triclosan; Triclosan - pharmacology; Whole Genome Sequencing

The horizontal transfer of plasmids has been recognized as one of the key drivers for the worldwide spread of antimicrobial resistance (AMR) across bacterial pathogens. However, knowledge remain limited about the contribution made by environmental stress on the evolution of bacterial AMR by modulati...