Uncovering the mechanism of Huangkui capsule in the treatment of diabetic kidney disease based on network pharmacology and experimental validation - Liu, Junhong; Li, Ziwei; Zhang, ZongYao; Shen, Zhongyuan (Scientific reports, 2025)
Keywords: 692/163; 692/4022/1585; AKT1 protein; Apoptosis; Apoptosis - drug effects; Capsules; Cell Line; Diabetes; Diabetes mellitus; Diabetic kidney disease; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Enzyme-linked immunosorbent assay; Experimental validation; Flow cytometry; Genes; Huangkui capsule; Humanities and Social Sciences; Humans; Immunofluorescence; Kidney diseases; Kidneys; Molecular docking; Molecular Docking Simulation; Molecular dynamics; Molecular Dynamics Simulation; Molecular modelling; multidisciplinary; Network Pharmacology; Oxidative stress; Oxidative Stress - drug effects; p53 Protein; Pharmacology; Protein interaction; Protein Interaction Maps - drug effects; Science; Science (multidisciplinary); Experimental validation; Network pharmacology; Huangkui capsule; Molecular docking; Diabetic kidney disease