Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults

• Published in: Experimental gerontology Vol. 127; p. 110722
• Main Authors: Fielding, Roger A., Reeves, Andrew R., Jasuja, Ravi, Liu, Christine, Barrett, Brittany B., Lustgarten, Michael S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.11.2019
• Subjects: Aged; Aged, 80 and over; Aging; Animals; Bacteroidetes - isolation & purification; Bacteroidetes - physiology; Body composition; Body Composition - physiology; digestive system; Exercise - physiology; Fecal Microbiota Transplantation - methods; Feces - microbiology; Female; Gastrointestinal Microbiome - physiology; gerontology; Humans; intestinal microorganisms; lean body mass; Male; Microbiome; Muscle strength; Muscle Strength - physiology; Muscle, Skeletal - physiology; Physical function; Prevotella; Prevotella - isolation & purification; Prevotella - physiology; Sarcopenia; Sarcopenia - physiopathology; Aging; Sarcopenia; Muscle strength; Body composition; Physical function; Microbiome

Evidence in support of a gut-muscle axis has been reported in rodents, but studies in older adult humans are limited. Accordingly, the primary goals of the present study were to compare gut microbiome composition in older adults that differed in terms of the percentage of whole body lean mass and ph...