Signaling pathways and defense mechanisms of ferroptosis

• Published in: The FEBS journal Vol. 289; no. 22; pp. 7038 - 7050
• Main Authors: Liu, Jiao, Kang, Rui, Tang, Daolin
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2022
• Subjects: antioxidant activity; Antioxidants; Antioxidants - pharmacology; autophagy; Cell death; Cleavage; cleavage (chemistry); Coenzyme Q10; Damage; Defense Mechanisms; Fatty acids; Ferroptosis; Ferroptosis - genetics; Glutathione; Iron; Iron - metabolism; lipid metabolism; Lipid peroxidation; Lipids; membrane repair; Membranes; Mitochondria; Nox protein; Peroxidation; Phospholipids; plasma membrane; Polyunsaturated fatty acids; Reactive oxygen species; Reactive Oxygen Species - metabolism; Regulatory mechanisms (biology); Signal Transduction; Signaling; Substrates; Tetrahydrobiopterin; transcription (genetics); autophagy; ferroptosis; cell death; lipid metabolism; membrane repair

As a type of lytic cell death driven by unrestricted lipid peroxidation and subsequent plasma membrane damage, ferroptosis occurs and develops because of sophisticated signals and regulatory mechanisms. The reactive oxygen species (ROS) used to initiate ferroptosis come from a variety of sources, in...