Strain Differences in Behavioral Inhibition in a Go/No-go Task Demonstrated Using 15 Inbred Mouse Strains

• Published in: Alcoholism, clinical and experimental research Vol. 34; no. 8; pp. 1353 - 1362
• Main Authors: Gubner, Noah R., Wilhelm, Clare J., Phillips, Tamara J., Mitchell, Suzanne H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2010; Wiley
• Subjects: Alcoholism and acute alcohol poisoning; Animals; Biological and medical sciences; Ethanol; Go/No-go; Heritability; Impulsive Behavior - genetics; Impulsive Behavior - psychology; Impulsivity; Inbred Strains; Inhibition; Inhibition, Psychological; Locomotion; Male; Medical sciences; Mice; Mice, 129 Strain; Mice, Inbred A; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred NZB; Motor Activity - genetics; Motor Activity - physiology; Psychomotor Performance - physiology; Species Specificity; Toxicology; Behavioral inhibition; Impulsivity; Ethanol; Rodentia; Strain specificity; Strain; Alcoholic beverage; Locomotion; Vertebrata; Mammalia; Mouse; Go/No-go; Animal; Go/NoGo task; Inbred Strains; Inbred; Heritability; Inhibitor; Mice; Inhibition

Background:  High levels of impulsivity have been associated with a number of substance abuse disorders including alcohol abuse. Research has not yet revealed whether these high levels predate the development of alcohol abuse. Methods:  The current study examined impulsivity in 15 inbred strains of...