Taurine stimulates proliferation of mice embryonic cultured neural progenitor cells

• Published in: Journal of neuroscience research Vol. 88; no. 8; pp. 1673 - 1681
• Main Authors: Hernández-Benítez, Reyna, Pasantes-Morales, Herminia, Saldaña, Ismael Torres, Ramos-Mandujano, Gerardo
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2010
• Subjects: Analysis of Variance; Animals; brain development; Bromodeoxyuridine - metabolism; Cell Differentiation - drug effects; Cell Proliferation - drug effects; Cell Survival - drug effects; Cells, Cultured; Chromatography, High Pressure Liquid - methods; Dose-Response Relationship, Drug; EGF; Embryo, Mammalian; Epidermal Growth Factor - pharmacology; FGFb; Fibroblast Growth Factors - pharmacology; Glial Fibrillary Acidic Protein - metabolism; Mesencephalon - cytology; Mice; Neurons - drug effects; neurospheres; Stem Cells - drug effects; Taurine - metabolism; Taurine - pharmacology; trophic factor; Tubulin - metabolism

Taurine is present in high levels in fetal brain which decrease in the adult, suggesting its role in brain development. In some regions of taurine deficient animals cells show defective migration and the presence of numerous mitotic figures, suggesting a delay in cell proliferation. To know more abo...