Angiotensin II stimulates α-skeletal actin expression in cadiomyocytes in vitro and in vivo in the absence of hypertension

• Published in: Differentiation (London) Vol. 69; no. 1; pp. 66 - 74
• Main Authors: Clément, Sophie, Pellieux, Corinne, Chaponnier, Christine, Pedrazzini, Thierry, Gabbiani, Giulio
• Format: Journal Article
• Language: English
• Published: Berlin/Wien Elsevier B.V 01.12.2001; Blackwell Wissenschafts‐Verlag; Blackwell
• Subjects: Actins - metabolism; Angiotensin II - physiology; Animals; Base Sequence; Biological and medical sciences; cardiac hypertrophy; Cell Differentiation - physiology; Cell differentiation, maturation, development, hematopoiesis; Cell physiology; DNA Primers; Fundamental and applied biological sciences. Psychology; gene expression; Hypertension - metabolism; In Vitro Techniques; Mice; Mice, Transgenic; Molecular and cellular biology; Myocardium - cytology; Myocardium - metabolism; myocytes; Rats; Rats, Wistar; renin; Renin - genetics; TGF-β; TGF-β; cardiac hypertrophy; renin; gene expression; myocytes; Myoblast; In vivo

Using a specific α-skeletal actin antibody, we have previously shown, that during hypertension-associated cardiac hypertrophy in the rat, the expression of α-skeletal actin in the myocardium is increased, but maintains focal distribution, compared to normotensive animals. In the present study, we ha...